Patents by Inventor Lisa Vivian Kalman

Lisa Vivian Kalman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thermostable DNA polymerases incorporating nucleoside triphosphates labeled with fluorescent dyes
    Patent number: 7598032
    Abstract: Modified thermostable DNA polymerases having enhanced efficiency for incorporating unconventional nucleotides such as those labeled with fluorescein family dyes are advantageous in many in vitro DNA synthesis applications. Such enzymes are particularly useful for use in chain termination nucleic acid sequencing protocols, as are native forms of such enzymes. Genes encoding the modified enzymes and methods for their production and use offer cost and efficiency advantages for DNA sequencing.
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: October 6, 2009
    Assignee: Roche Molecular Systems
    Inventors: David Harrow Gelfand, Lisa Vivian Kalman, Fred Lawrence Reichert, Christopher Lim Sigua, Thomas W. Myers
  • Thermostable DNA polymerases incorporating nucleoside triphosphates labeled with fluorescent dyes
    Publication number: 20030152988
    Abstract: Modified thermostable DNA polymerases having enhanced efficiency for incorporating unconventional nucleotides such as those labeled with fluorescein family dyes are advantageous in many in vitro DNA synthesis applications. Such enzymes are particularly useful for use in chain termination nucleic acid sequencing protocols, as are native forms of such enzymes. Genes encoding the modified enzymes and methods for their production and use offer cost and efficiency advantages for DNA sequencing.
    Type: Application
    Filed: January 30, 2003
    Publication date: August 14, 2003
    Inventors: David Harrow Gelfand, Lisa Vivian Kalman, Fred Lawrence Reichert, Christopher Lim Sigua, Thomas W. Myers
  • Thermostable DNA polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes
    Publication number: 20020142333
    Abstract: Modified thermostable DNA polymerases having enhanced efficiency for incorporating unconventional nucleotides such as those labeled with fluorescein family dyes are advantageous in many in vitro DNA synthesis applications. Such enzymes are particularly useful for use in chain termination nucleic acid sequencing protocols, as are native forms of such enzymes. Genes encoding the modified enzymes and methods for their production and use offer cost and efficiency advantages for DNA sequencing.
    Type: Application
    Filed: January 17, 2002
    Publication date: October 3, 2002
    Applicant: F. Hoffmann-La Roche AG.
    Inventors: David Harrow Gelfand, Lisa Vivian Kalman, Fred Lawrence Reichert, Christopher Lim Sigua, Thomas W. Myers
  • Thermostable DNA polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes
    Patent number: 6346379
    Abstract: Modified thermostable DNA polymerases having enhanced efficiency for incorporating unconventional nucleotides such as those labeled with fluorescein family dyes are advantageous in many in vitro DNA synthesis applications. Such enzymes are particularly useful for use in chain termination nucleic acid sequencing protocols, as are native forms of such enzymes. Genes encoding the modified enzymes and methods for their production and use offer cost and efficiency advantages for DNA sequencing.
    Type: Grant
    Filed: September 3, 1998
    Date of Patent: February 12, 2002
    Assignee: F. Hoffman-La Roche AG
    Inventors: David Harrow Gelfand, Lisa Vivian Kalman, Fred Lawrence Reichert, Christopher Lim Sigua, Thomas W. Myers
  • Thermostable DNA polymerases having reduced discrimination against ribo-NTPs
    Patent number: 5939292
    Abstract: Modified thermostable DNA polymerases having enhanced efficiency for incorporating unconventional nucleotides, such as ribonucleotides, into DNA products, are advantageous in many in vitro synthesis applications. Such enzymes are particularly useful for use in nucleic acid sequencing protocols and provide novel means for DNA sequence analysis. Genes encoding the modified enzymes and methods for their production and use offer cost and efficiency advantages for DNA sequencing.
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: August 17, 1999
    Assignee: Roche Molecular Systems, Inc.
    Inventors: David Harrow Gelfand, Lisa Vivian Kalman, Fred Lawrence Reichert