Patents by Inventor Lisa VON KLEIST

Lisa VON KLEIST has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic-compounds for use as a medicament, in particular for treatment of parkinson's disease
    Patent number: 11008282
    Abstract: The invention relates to novel small molecule compounds having a basic structure as depicted by formula (A), where in particular exemplary embodiments R1 is —OH, R2 is —NO2 and R3 is H, R4 and R5 are H, one of R6 and R7 is selected from H, —CONH2, and —CONR92, and the other one is selected from —CONR92 and —CONR11R9, wherein R9 and R11 are (possibly multiply) substituted alkyl and H or alkyl, respectively. The compounds of the invention inhibit the enzyme Catechol-O-methyltransferase (COMT) and exhibit a low off-target profile. The compounds are provided for use as a medicament, in particular for use in prevention or treatment of Parkinson's disease.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: May 18, 2021
    Inventors: Hubert Koester, Lisa Von Kleist, Simon Michaelis, Kathrin Bartho, Marén Schlief, Mathias Dreger, Anna K. Schrey, Michael Sefkow, Friedrich Kroll, Daniel Ohlendorf, Yan Luo
  • NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE
    Publication number: 20180370906
    Abstract: The invention relates to novel small molecule compounds having a basic structure as depicted by formula (A), where in particular exemplary embodiments R1 is —OH, R2 is —NO2 and R3 is H, R4 and R5 are H, one of R6 and R7 is selected from H, —CONH2, and —CONR92, and the other one is selected from —CONR92 and —CONR11R9, wherein R9 and R11 are (possibly multiply) substituted alkyl and H or alkyl, respectively. The compounds of the invention inhibit the enzyme Catechol-O-methyltransferase (COMT) and exhibit a low off-target profile. The compounds are provided for use as a medicament, in particular for use in prevention or treatment of Parkinson's disease.
    Type: Application
    Filed: December 19, 2016
    Publication date: December 27, 2018
    Inventors: Hubert KOESTER, Lisa VON KLEIST, Simon MICHAELIS, Kathrin BARTHO, Marén SCHLIEF, Mathias DREGER, Anna K. SCHREY, Michael SEFKOW, Friedrich KROLL, Daniel OHLENDORF, Yan LUO