Abstract: A smart doorbell is provided. The doorbell may be connected to a remote device. The doorbell comprises a processor: a call button configured to output a first signal when the call button is actuated by a user; and a temperature sensor positioned with respect to the call button such that when the call button is actuated by a user, the temperature sensor is capable of taking temperature measurements on a part of the user's wrist facing the temperature sensor. In response to the call button being actuated by a user, the processor is configured to receive the first signal from the call button: command the temperature sensor to measure a temperature of a part of the user's wrist: compare the temperature measured by the temperature sensor to a predefined threshold temperature: output a second signal according to the comparison between the temperature measured by the temperature sensor and the predefined threshold; and transmit the first signal and the second signal to at least one remote device via the network.

Abstract: The present disclosure provides computer-implemented methods, systems, and devices for generating multistep explanations for pedagogical exercises. A computing device receives a query from a user. The computing device determines that the query includes query data describing a pedagogical exercise to be solved. The computing device provides the query data as input to an explanatory machine-learned model. The computing device receives, as output from the explanatory machine-learned model, a pedagogical response, the pedagogical response including a multi-step explanation of a solution to the pedagogical exercise. The computing device provides the pedagogical response for display to a user.

Abstract: The disclosure provides for metal organic frameworks (MOFs) which comprise a plurality of SBUs comprising different metals or metal ions and/or a plurality of organic linking moieties comprising different functional groups.

Abstract: The disclosure provides for metal organic frameworks (MOFs) which comprise a plurality of SBUs comprising different metals or metal ions and/or a plurality of organic linking moieties comprising different functional groups.

Abstract: The present invention relates to the use of inhibitors of FtsZ, an ancestral tubulin of prokaryotes, to restore susceptibility to ?-lactam antibiotics, including carbapenems and cephalosporins, particularly in methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphyloccus epidermis (MRSE), and other coagulase negative staphylococci (MRCNS).

Abstract: A pillow cover includes a pillow casing and a neck support provided thereon. A neck support includes an elongated retention pocket and a neck supporting element received in the retention pocket therewithin. The user is able to use his or her own pillow to incorporate with the pillow cover such that when the user sleeps in a bed by using his or her own pillow for head support in a comfortable way, the neck support of the pillow cover provides a substantial neck support to keep the neck of the user in alignment with the spine while sleeping.

Abstract: A pillow cover includes a pillow casing and a neck support provided thereon. A neck support includes an elongated retention pocket and a neck supporting element received in the retention pocket therewithin. The user is able to use his or her own pillow to incorporate with the pillow cover such that when the user sleeps in a bed by using his or her own pillow for head support in a comfortable way, the neck support of the pillow cover provides a substantial neck support to keep the neck of the user in alignment with the spine while sleeping.

Abstract: &agr;-ketoamide compounds useful for treating disorders mediated by 20S proteasome in mammals having the following formula: wherein X2 is Ar or Ar—X3 wherein X3 is is —C═O, or —CH2CO—, and wherein Ar is phenyl, substituted phenyl, indole, substituted indoles, and any other heteroaryls; R1, and R2 are each individually selected from the side chains of the known natural &agr;-amino acids and unnatural amino acids, hydrogen, 1-10 carbon linear and branched alkyl, 1-10 carbon linear and branched substituted alkyl, aryl, substituted aryl, 1-10 carbon linear, branched substituted aryl, alkoxyaryl, 3-8 carbon cycloalkyl, heterocycle substituted heterocycle, heteroaryl and substituted heteroaryl; X1 is selected from hydroxide, monoalkylamino, dialkylamino, alkoxide, arylkoxide and wherein X4 is hydroxide, arylamino, monoalkylamino, dialkylamino, alkoxide, or arylalkoxide; and R3 is selected from the known natural &agr;-amino acids, unnatural amino acids

Abstract: Esters of N6-oxa, thia, thioxa and azacycloalkyl substituted adenosine derivatives having the following formula; wherein the compounds are selective adenosine type 1 receptor agonists that are useful for the treatment cardiovascular diseases and central nervous system disorders.

Abstract: A substituted N6-oxa, thia, thioxa and azacycloalkyl substituted adenosine derivative and a method for using the composition as an A1 adenosine receptor agonist.

Abstract: .alpha.-ketoamide compounds useful for treating disorders mediated by 20S proteasome in mammals having the following formula: wherein X.sub.2 is Ar or Ar--X.sub.3 wherein X.sub.3 is --C.dbd.O, or --CH.sub.2 CO--, and wherein Ar is phenyl, substituted phenyl, indole, substituted indoles, and any other heteroaryls; R.sub.1, and R.sub.2 are each individually selected from the side chains of the known natural .alpha.-amino acids and unnatural amino acids, hydrogen, 1-10 carbon linear and branched alkyl, 1-10 carbon linear and branched substituted alkyl, aryl, substituted aryl, 1-10 carbon linear, branched substituted aryl, alkoxyaryl, 3-8 carbon cycloalkyl, heterocycle substituted heterocycle, heteroaryl and substituted heteroaryl; X.sub.1 is selected from hydroxide, monoalkylamino, dialkylamino, alkoxide, arylkoxide and ##STR1## wherein X.sub.4 is hydroxide, arylamino, monoalkylamino, dialkylamino, alkoxide, or arylalkoxide; and R.sub.3 is selected from the known natural .alpha.

Abstract: Osmium-catalyzed methods of addition to an olefin are discussed. In the method of asymmetric dihydroxylation of the present invention, an olefin, a chiral ligand, an organic solvent, water, an oxidant and an osmium-containing compound are combined. In the method of asymmetric oxyamination of the present invention, an olefin, a chiral ligand, an organic solvent, water, a metallochloramine derivative, an osmium-containing compound and, optionally, a tetraalkyl ammonium compound are combined. In the method of asymmetric diamination of the present invention, an olefin, a chiral ligand, an organic solvent, a metallo-chloramine derivative, an amine and an osmium-containing compound are combined. In one embodiment, an olefin, a chiral ligand which is a polymeric dihydroquinidine derivative or a dihydroquinine derivative, acetone, water, a base, an oxidant and osmium tetroxide are combined to effect asymmetric dihydroxylation of the olefin.