Abstract: The current disclosure address a need in the art by providing methods and compositions for treating migraines and certain pain-related disorders with a combination therapy. Accordingly, aspects of the disclosure relate to a method for treating a migraine, post-traumatic headache, or chronic pain syndrome patient, the method comprising administering to the patient an effective amount of an insulin growth factor receptor (IGFR) activator and a calcitonin gene-related peptide (CGRP) inhibitor. Further aspects relate to a composition comprising insulin-like growth factor-1 (IGF-1) and a CGRP inhibitor. Also provided are methods for treating fibromyalgia or chronic fatigue syndrome in a patient, the method comprising administering to the patient an effective amount of an insulin growth factor receptor (IGFR) activator.

Abstract: The present invention provides a novel proteinaceous composition that increases the levels of dopamine (DA) in neurons. Therefore, provided are methods for treating conditions caused by the deficiency of dopamine and/or by the loss of DA neurons or injury to DA neurons. An example includes Parkinson's disease. Also provided are methods for isolating and partially purifying the proteins and further characterizing the same.