Patents by Inventor Lise Roth

Lise Roth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides
    Patent number: 10179801
    Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences, such as truncated LyP-1 peptides, that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: January 15, 2019
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara, Lise Roth
  • PEPTIDIC ANTAGONISTS OF CLASS III SEMAPHORINS/NEUROPILINS COMPLEXES
    Publication number: 20150307589
    Abstract: The present invention concern a peptidic antagonist of class III semaphorins/neuropilins complexes comprising an amino acid sequence, which is derived from the transmembrane domain of a protein selected in the group consisting of neuropilin-1, neuropilin-2, plexin-A1, plexin-A2, plexin-A3, plexin-A4, Nr-CAM, L1-CAM, integrin Beta 1 and integrin beta 2, and including at least a GxxxG motif, eventually fused to an heterologous sequence; a nucleic acid encoding for said peptidic antagonist, a pharmaceutical composition comprising such a peptidic antagonist or a nucleic acid encoding thereof and uses thereof.
    Type: Application
    Filed: January 16, 2015
    Publication date: October 29, 2015
    Applicants: INSERM - INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, Universite De Strasbourg
    Inventors: Dominique BAGNARD, Lise Roth, Cecile Nasarre, Pierre Hubert, Sylvie Dirrig-Grosch, Gerard Cremel, Dominique Aunis
  • Truncated LYP-1 Peptides and Methods and Compositions Using Truncated LYP-1 Peptides
    Publication number: 20150259380
    Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences, such as truncated LyP-1 peptides, that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
    Type: Application
    Filed: August 24, 2012
    Publication date: September 17, 2015
    Applicant: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara, Lise Roth
  • Peptidic antagonists of class III semaphorins/neuropilins complexes
    Patent number: 8956622
    Abstract: The present invention concern a peptidic antagonist of class III semaphorins/neuropilins complexes comprising an amino acid sequence, which is derived from the transmembrane domain of a protein selected in the group consisting of neuropilin-1, neuropilin-2, plexin-A1, plexin-A2, plexin-A3, plexin-A4, Nr-CAM, L1-CAM, integrin Beta 1 and integrin beta 2, and including at least a GxxxG motif, eventually fused to an heterologous sequence; a nucleic acid encoding for said peptidic antagonist, a pharmaceutical composition comprising such a peptidic antagonist or a nucleic acid encoding thereof and uses thereof.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: February 17, 2015
    Assignee: INSERM—Institut National de la Sante et de la Recherche Medicale
    Inventors: Dominique Bagnard, Lise Roth, Cécile Nasarre, Pierre Hubert, Sylvie Dirrig-Grosch, Gerard Cremel, Dominique Aunis
  • PEPTIDIC ANTAGONISTS OF CLASS III SEMAPHORINS/NEUROPILINS COMPLEXES
    Publication number: 20100222261
    Abstract: The present invention concern a peptidic antagonist of class III semaphorins/neuropilins complexes comprising an amino acid sequence, which is derived from the transmembrane domain of a protein selected in the group consisting of neuropilin-1, neuropilin-2, plexin-A1, plexin-A2, plexin-A3, plexin-A4, Nr-CAM, L1-CAM, integrin Beta 1 and integrin beta 2, and including at least a GxxxG motif, eventually fused to an heterologous sequence; a nucleic acid encoding for said peptidic antagonist, a pharmaceutical composition comprising such a peptidic antagonist or a nucleic acid encoding thereof and uses thereof.
    Type: Application
    Filed: June 28, 2006
    Publication date: September 2, 2010
    Inventors: Dominique Bagnard, Lise Roth, Cecile Nasarre, Pierre Hubert, Sylvie Dirrig-Grosch, Gerard Cremel, Dominique Aunis