Patents by Inventor Lisette SANDERS

Lisette SANDERS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant expression of PCV2b ORF2 protein in insect cells
    Patent number: 11279952
    Abstract: The present invention relates to the field of veterinary vaccines, in particular to porcine vaccines against PCV2 and associated diseases. Specifically the invention relates to the finding that a mutation is required in PCV2b ORF2 protein, to prevent its nuclear accumulation upon expression in insect cells; the mutation introduces a Proline at amino acid position 131. This allows efficient expression in insect cells, easy harvesting, and generates large amounts of virus-like particles. The VLPs are highly effective in vaccines for porcines for reduction of infection by PCV2 or of associated signs of disease.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: March 22, 2022
    Assignee: Intervet Inc.
    Inventors: Paulus Jacobus Antonius Sondermeijer, Lisette Sanders, Karin Huberdina Antonia Van Der Heijden-Liefkens
  • RECOMBINANT EXPRESSION OF PCV2B ORF2 PROTEIN IN INSECT CELLS
    Publication number: 20200299726
    Abstract: The present invention relates to the field of veterinary vaccines, in particular to porcine vaccines against PCV2 and associated diseases. Specifically the invention relates to the finding that a mutation is required in PCV2b ORF2 protein, to prevent its nuclear accumulation upon expression in insect cells; the mutation introduces a Proline at amino acid position 131. This allows efficient expression in insect cells, easy harvesting, and generates large amounts of virus-like particles. The VLPs are highly effective in vaccines for porcines for reduction of infection by PCV2 or of associated signs of disease.
    Type: Application
    Filed: October 16, 2018
    Publication date: September 24, 2020
    Applicant: Intervet Inc.
    Inventors: Paulus Jacobus Antonius SONDERMEIJER, Lisette SANDERS, Karin Huberdina Antonia VAN DER HEIJDEN-LIEFKENS