Abstract: Aspects of the disclosure are directed to a storage device including a memory and a controller. In some examples, the controller is configured to measure an error rate of one or more blocks of the memory. In some examples, the controller is further configured to estimate, based at least in part on the error rate, a time shift indicative of a duration of time for which the storage device was powered off. In some examples, the controller is further configured to set a read level for multiple blocks of the memory, wherein the read level is determined based at least in part on the time shift.

Abstract: A high-brightness picosecond laser system, comprising a fully polarization-maintaining fiber picosecond seed laser (1), a fiber collimator (2), a space isolator (3), a polarization splitting prism (5), a first-stage solid traveling wave amplifier (6), a second-stage solid traveling wave amplifier (7), and a third-stage solid traveling wave amplifier (8) which are sequentially arranged in the laser transmission direction. The first-stage solid traveling wave amplifier (6) is located on the transmission light side of the polarization splitting prism (5), the second-stage solid traveling wave amplifier (7) is located on the reflected light side of the polarization splitting prism (5), and the fiber collimator (2) is connected to the fully polarization-maintaining fiber picosecond seed laser (1) by means of a tail fiber.

Abstract: Provided are a quinazoline compound and an application thereof. Specifically provided is a quinazoline compound as shown in formula I. The compound is novel in structure and has a good inhibitory effect on cell factors TNF-?, IL-6, and IL-I?.

Abstract: An auger-suction type metro jet system (MJS) device for aerated and lightweight cement soil includes a multi-pipe device, an outer sleeve, an integrated device, a spiral conveyor, a reamer head, a pressure monitoring system, a mass measuring device, and a control console. The multi-pipe device integrates a backup pipe, a negative-pressure gas pipe, a hydraulic pipe, a negative-pressure water pipe, a pressure sensor wire pipe, a pressure water pipe, a backup gas pipe, a power wire pipe, and at least one grouting tremie unit. The spiral conveyor includes a shaft-type spiral conveying belt and a negative-pressure device. A construction method for foundation reinforcement construction includes: cutting soil by the reamer head; crushing gravel by a gravel crusher; transporting, by the shaft-type spiral conveying belt, a soil-water mixture to a waste liquid tank; monitoring, by the mass measuring device, a mass of the soil-water mixture discharged; and injecting equal-mass cement.

Abstract: Aspects of a storage device including a memory and a controller are provided. The controller may determine to perform garbage collection on a superblock. During the garbage collection process, the controller will typically move the superblock into an erase pool for erasing the superblock. However, aspects of the disclosure are directed to a method of measuring a raw bit error rate (RBER) of the superblock prior to erasure. The measured RBER may be used to estimate a data retention time of the storage device and provide the customer with an early warning notification if a health metric of the storage devices reaches a threshold retention time.

Abstract: Aspects of a storage device including a memory and a controller are provided. The controller may measure an error rate of one or more blocks of the memory. In certain aspects, the controller may also estimate, based at least in part on the error rate, a time shift indicative of a duration of time for which the storage device was powered off. In some examples, the controller may also set a read level for multiple blocks of the memory, wherein the read level is determined based at least in part on the time shift.

Abstract: Provided are a compound represented by Formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof, and a use thereof in preparing a drug for diseases mediated by CBP and/or EP300.

Abstract: A method for treating waste gases containing low-concentration volatile organic compounds (VOCs) based on combination of adsorption and in-situ temperature-varying catalytic ozonation, relating to treatment of organic waste gases. In the method, a VOCs-containing waste gas is fed to an adsorption bed for enrichment, which includes a low-temperature regeneration process and a high-temperature regeneration process. A catalyst with high adsorption capacity and catalytic activity is loaded on the adsorption bed.

Abstract: Provided are novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R4, m, n, and p are as described herein. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Abstract: This invention relates to new benzazepine carboxamide compounds of the formula wherein X and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR8 agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.

Abstract: The present invention relates to compounds of formula (I), wherein R1 to R4 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y and R2 are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: A pipeline robot, a pipeline video signal acquisition and transmission device, and a pipeline detection system and method. The pipeline robot comprises a camera module and a crawler, wherein the camera module comprises a front-view digital camera, a first microprocessor and a rotation motor; the crawler comprises a frame body, wheels on the both sides of the frame body, a driving motor, a sensor group, a second microprocessor, a network transmission module and a first power carrier module; a cable reel comprises a power line, a second power carrier module, a fourth microprocessor and a network communication module; and an acquisition control terminal is a mobile terminal provided with a detection module.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y and R2 are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds.

Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Abstract: The present invention relates to compounds of formula (I), wherein R1 to R4 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.