Patents by Inventor Lisong Long

Lisong Long has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Doripenem intermediate compound, preparation process therefor and use thereof, and preparation process for doripenem
    Patent number: 9169258
    Abstract: The present invention provides a doripenem intermediate compound shown by formula (XIV), wherein PNB is p-nitrobenzyl, and HX is an acid; and when HX is a monobasic acid, n=1; and when HX is a polybasic acid, n=2. The present invention also provides a process for preparing the doripenem intermediate compound (XIV). In addition, the present invention provides a process for preparing doripenem (I) from the doripenem intermediate compound (XIV) in a simple manner, with a high yield and low production costs. The new mono-protected doripenem intermediate compound provided in the present invention contains only one protecting group, reducing the difficulty and complexity in the subsequent de-protection step by catalytic hydrogenation, increasing the yield of the catalytic hydrogenation reaction, and thus reducing the production cost of the final product. The process is easy to operate and suitable for industrialized production.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 27, 2015
    Assignee: Shenzhen Haibin Pharmaceutical Co., Ltd.
    Inventors: Lisong Long, Zhaoqiang Lu, Cheng Ding, Guangcheng Li, Zhili Lv, Congquan Wu, Yanjun Zhang, Peng Ren
  • DORIPENEM INTERMEDIATE COMPOUND, PREPARATION PROCESS THEREFOR AND USE THEREOF, AND PREPARATION PROCESS FOR DORIPENEM
    Publication number: 20150038700
    Abstract: The present invention provides a doripenem intermediate compound shown by formula (XIV), wherein PNB is p-nitrobenzyl, and HX is an acid; and when HX is a monobasic acid, n=1; and when HX is a polybasic acid, n=2. The present invention also provides a process for preparing the doripenem intermediate compound (XIV). In addition, the present invention provides a process for preparing doripenem (I) from the doripenem intermediate compound (XIV) in a simple manner, with a high yield and low production costs. The new mono-protected doripenem intermediate compound provided in the present invention contains only one protecting group, reducing the difficulty and complexity in the subsequent de-protection step by catalytic hydrogenation, increasing the yield of the catalytic hydrogenation reaction, and thus reducing the production cost of the final product. The process is easy to operate and suitable for industrialized production.
    Type: Application
    Filed: September 26, 2012
    Publication date: February 5, 2015
    Inventors: Lisong Long, Zhaoqiang Lu, Cheng Ding, Guangcheng Li, Zhili Lv, Congquan Wu, Yanjun Zhang, Peng Ren