Abstract: A system for biology based anti-tamper and a method for detecting a tampering activity to an object using biological materials are provided. The system includes a biological medium that includes a biological member such as deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and/or live or hibernating organism. The biological medium is applied to a portion of an object that is required to monitor whether any tampering may have occurred. The biological member is engineered to change its state when exposed to a stimulus. Upon suspicion, the state of the biological member is examined to find if there is any change of state. The biological member is capable of being barcoded, which provides an extra security measure.