Abstract: The present invention is directed to binding molecules that possess one or more epitope-binding sites specific for an epitope of CD137 and one or more epitope-binding sites specific for an epitope of a tumor antigen (“TA”) (e.g., a “CD137×TA Binding Molecule”). In one embodiment, such CD137×TA Binding Molecules will be bispecific molecules, especially bispecific tetravalent diabodies, that are composed of two, three, four or more than four polypeptide chains and possessing two epitope-binding sites each specific for an epitope of CD137 and two epitope-binding sites each specific for an epitope of a TA. Alternatively, such CD137×TA Binding Molecules will be bispecific molecules, especially bispecific trivalent binding molecules composed of three or more polypeptide chains and possessing one or two epitope-binding sites each specific for an epitope of CD137 and one or two epitope-binding sites each specific for an epitope of a TA.

Abstract: Disclosed are various embodiments facilitating a holistic engagement with a user across multiple communication channels of an organization or an enterprise based at least in part on a determined user intent. As users interact with various services associated with the organization through one or more communication channels, interaction data can be captured and stored. In various examples, the interaction data that is stored by the various services can be obtained and organized according to a predefined schema. The organized interaction data can be applied to a trained intent model that outputs a user intent based at least in part on observations of other users with similar histories. The predicted intent can be provided to the different services such that subsequent interactions between the user and the organization can be based at least in part on the intent in a consistent manner, regardless of the communication channel associated with the interaction.

Abstract: Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, compositions thereof, and methods of their use.

Abstract: Techniques convey, cool and energy recuperate hot material from a combustion boiler of a combustion plant. Such techniques involve: a) issue of the hot material from a material issue orifice of a combustion boiler into a capture region of a housing, a conveyor belt being arranged in the housing, b) conveyance of the hot material through a cooling region in the housing, c) cooling of the hot material in the cooling region by means of a cooling-air stream moving in the opposite direction to the material, d) removal of at least part of the heated cooling-air stream out of at least one region adjacent to the capture region of the housing, and e) delivery of the removed cooling-air stream to at least one region, carrying combustion exhaust gases, of the combustion plant.

Abstract: Techniques convey, cool and energy recuperate hot material from a combustion boiler of a combustion plant. Such techniques involve: a) issue of the hot material from a material issue orifice of a combustion boiler into a capture region of a housing, a conveyor belt being arranged in the housing, b) conveyance of the hot material through a cooling region in the housing, c) cooling of the hot material in the cooling region by means of a cooling-air stream moving in the opposite direction to the material, d) removal of at least part of the heated cooling-air stream out of at least one region adjacent to the capture region of the housing, and e) delivery of the removed cooling-air stream to at least one region, carrying combustion exhaust gases, of the combustion plant.