Patents by Inventor Liu Xing

Liu Xing has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imatinib production process
    Patent number: 7550591
    Abstract: Provided is a process for producing imatinib and salts thereof, e.g., imatinib mesylate. The process includes reacting 4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid with N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine in the presence of a carboxylic acid coupling reagent, to produce imatinib, and optionally converting the imatinib into a salt.
    Type: Grant
    Filed: May 2, 2007
    Date of Patent: June 23, 2009
    Assignee: Chemagis Ltd.
    Inventors: Liu Xing, He Xungui, Yuan Wang, Michel Bekhazi, Sonia Krivonos, Edna Danon
  • Process for preparing Imatinib
    Patent number: 7507821
    Abstract: A novel process is disclosed for producing Imatinib, using the precursor 2-chloro-4-(3-pyridyl)-pyrimidine, thus improving Imatinib preparation via an alternative synthetic route, avoiding the use of the toxic reagent cyanamide.
    Type: Grant
    Filed: December 28, 2005
    Date of Patent: March 24, 2009
    Assignee: Chemagis Ltd.
    Inventors: Huang Anli, Liu Xing, Lior Zelikovitch, Joseph Kaspi
  • IMATINIB PRODUCTION PROCESS
    Publication number: 20080275055
    Abstract: Provided is a process for producing imatinib and salts thereof, e.g., imatinib mesylate. The process includes reacting4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid with N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine in the presence of a carboxylic acid coupling reagent, to produce imatinib, and optionally converting the imatinib into a salt.
    Type: Application
    Filed: May 2, 2007
    Publication date: November 6, 2008
    Applicant: CHEMAGIS LTD.
    Inventors: Liu Xing, He Xungui, Yuan Wang, Michel Bekhazi, Sonia Krivonos, Edna Danon
  • Novel process for preparing Imatinib
    Publication number: 20060149061
    Abstract: A novel process is disclosed for producing Imatinib, using the precursor 2-chloro-4-(3-pyridyl)-pyrimidine, thus improving Imatinib preparation via an alternative synthetic route, avoiding the use of the toxic reagent cyanamide.
    Type: Application
    Filed: December 28, 2005
    Publication date: July 6, 2006
    Inventors: Huang Anli, Liu Xing, Lior Zelikovitch, Joseph Kaspi