Abstract: Provided are certain Bcl-2 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: Disclosed are methods of using inhibitors of tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1), e.g., in the treatment of subjects in need thereof.

Abstract: A computing device includes an image sensor, an IMU, a display, and a processor coupled to the image sensor, the IMU, and the display. The processor is configured to generate a GUI current screen on the display. The GUI current screen includes a background, and foreground GUI elements overlaying the background. The processor is configured to when the IMU generates motion data indicative of movement, render the background to comprise a video image from the image sensor.

Abstract: An integrated circuit (IC) chip package and a method of fabricating the same are disclosed. The IC chip package includes a device layer on a first surface of a substrate, a first interconnect structure on the device layer, and a second interconnect structure on the second surface of the substrate. The first interconnect structure includes a fault detection line in a first metal line layer and configured to emit an electrical or an optical signal that is indicative of a presence or an absence of a defect in the device layer, a metal-free region on the fault detection line, and a metal line adjacent to the fault detection line in the first metal line layer. The fault detection line is electrically connected to the device layer.

Abstract: Provided are compositions and methods useful in the post-CMP cleaning of microelectronic devices, in particular, devices which contain one or more surfaces comprising hydrophobic carbon or SiC. In general, the compositions comprise a chelating agent; a water-miscible solvent; a reducing agent; and a pH adjustor, wherein the composition has a pH of about 2 to about 13.

Abstract: The invention relates to a system for reducing the hardness of a water body. According to the system, the acidic water body near a filter element anode is continuously extracted in the electrolytic process, the effect of acid-alkali separation can be achieved without internally disposing an ion exchange membrane, acid-alkali mixing generated by electrodes slows down, the alkaline atmosphere of a cathode chamber is kept, and a good environment is provided for generation of calcium carbonate seed crystals; and meanwhile, the acidic water body extracted near the anode of an electrochemical electrolysis unit can be used for regenerating ion exchange resin in an ion exchange column, so that resources are fully utilized.

Abstract: A method and an electronic apparatus for predicting a path based on an object interaction relationship are provided. The method includes the following. A video including a plurality of image frames is received. Object recognition is performed on a certain image frame among the plurality of image frames to recognize at least one object in the certain image frame. Preset interactive relationship information associated with the at least one object is obtained from an interactive relationship database based on the at least one object. A first trajectory for navigating the first vehicle is determined based on the preset interactive relationship information.

Abstract: A photochromic composition having at least one photochromic naphthopyran-based component with R? and R? groups selected from hydrogen, alkyl, fluorinated alkyl, alkenyl, alkynyl, alkylaryl, cycloalkyl, alkoxy, halogen, amine, carbonate ester, carboxylate, aryl, substituted aryl, heteroaryl, substituted heteroaryl or a heterocyclic group and Ar? and Ar? groups selected from unsubstituted or substituted cyclic five-membered or six-membered structures including benzene, pyridine, thiophene, furan, carbazole, triphenylamine, dibenzothiophene, dibenzofuran, fluorine, naphthalene, anthracene and pyrene. The photochromic composition is excitable under a visible light range to produce a color change. A second photochromic naphthopyran-based component with a different thermal decay rate constant (k) may further be included in the photochromic composition. The photochromic composition is incorporated into color-changing inks and polymers.

Abstract: The present disclosure provides an array substrate, a microfluidic device, a microfluidic system, and a fluorescence detection method. The array substrate includes at least one recess, the array substrate is located in a plane, and a ratio of an area of an orthographic projection of the at least one recess on the plane to an area of an orthographic projection of the array substrate on the plane is between 0.05 and 0.60.

Abstract: The present invention relates to solid forms of a substituted benzoxaborole compound, specifically crystalline forms of a compound of formula I, compositions comprising crystalline forms of the compound of formula (I), and methods of their use.

Abstract: An air release valve and an air pressure driven toilet water tank drain valve are provided. The air release valve includes a valve seat, a sliding block, and a push block. A bottom of the valve seat is provided with an air release channel, one end of the air release channel is an air inlet, and the other end of the air release channel forms an air release nozzle. The sliding block is located above the air release nozzle and is slidably arranged on the valve seat. The air pressure driven toilet water tank drain valve includes a drain valve body, an inner core tube, a limit device, a telescopic airbag, an air pump, the air release valve, a controller and an electronic induction switch. The air release valve with mechanical structure does not require power consumption and has low cost.

Abstract: A negative pressure massage apparatus includes a vacuum pump, two solenoid valves and a control board. The vacuum pump is used to generate a negative pressure outside the negative pressure massage apparatus. Two solenoid valves are used to control a gas flow input into the negative pressure massage apparatus. The control board is used to activate or stop at least one of the vacuum pumps, and the two solenoid valves. The present disclosure further includes a method of using the negative pressure massage apparatus.

Abstract: A helmet is disclosed including: a helmet body; a jaw guard with two fork handles through which the jaw guard is mounted on the helmet body and rotatable around a fixed axis relative to the helmet body; a shield assembly including a shield and a bracket, which is movable between a lowered position and a raised position relative to the helmet body; and a lifting mechanism including a trigger located beside the bracket of the shield assembly and driven by the fork handles of the jaw guard, and the trigger can touch the bracket of the shield assembly at the lowered position and raise the shield assembly from the lowered position. The lifting mechanism further includes an elastic element with one end connected with the bracket, which is arranged to make the shield assembly continue to move to the raised position after the shield assembly leaves the lowered position.

Abstract: The present disclosure provides an operation adjustment method for a metro train in a unidirectional jam, including: generating a train operation routing scheme in the jam according to a jam position; setting priorities for turnaround stations; determining an affected train set; predicting, according to the affected train set, arrival times of each affected train at the turnaround stations of the different priorities; determining, according to the time, planned train service to be executed by the affected train after turning around; and acquiring a planned train service canceled during the jam, and allocating, according to the planned train service canceled during the jam, a train resource for train addition or storage. The present disclosure avoid the conventional complicated operation of manually determining the affected train one by one, and reasonably adds the extra passenger train to arrive at the station on the line for passenger carrying.

Abstract: A method for preparing a large-size two-dimensional layered metal thiophosphate crystal includes the following steps: 1) weighing raw materials of indium spheres, phosphorous lumps and sulfur granules according to a predetermined amount and proportion, mixing them, and using iodine as a transport agent and potassium iodide as a molten salt; 2) adding the raw materials, the iodine and the potassium iodide to a reaction vessel together, and vacuum sealing it under a certain pressure, and then subjecting it to a high-temperature reaction; 3) taking out the products after the reaction, and washing the products to remove the residual iodine and potassium iodide and obtain large-size two-dimensional layered metal thiophosphate crystals. This method is simple and highly efficient.

Abstract: The present application provides a pixel electrode, a driving method of the pixel electrode, and a liquid crystal display panel, the pixel electrode comprises a frame electrode and a keel electrode, the frame electrode forms a closed region, the keel electrode is located in the closed region, the keel electrode comprises at least a first trunk and a second trunk vertically intersecting the first trunk, the first trunk and the second trunk divide the closed region into four sub areas, and a shape of an area composed of any two adjacent sub areas is pagoda shaped, to improve a light transmittance of the pixel electrode.

Abstract: An intelligent bathing bed is provided, which includes an underframe and a mattress. The mattress is arranged within the underframe, the mattress includes a fixed mattress and a movable mattress. The fixed mattress and the movable mattress are arranged at intervals in a same plane. The movable mattress is connected with the underframe through a water outlet pipe. The movable mattress includes a roller. A peripheral surface of the roller is provided with a water outlet array and a massaging head array. The water outlet array and the massaging head array are arranged at intervals. The intelligent bathing bed further includes a driving mechanism. The roller is connected with the driving mechanism, and the roller is driven by the driving mechanism to rotate along a central axis. The disclosure has advantages that it is less operation difficulty, can guarantee use safety of the users, and is suitable for the elderly population.

Abstract: Provided herein are radiopharmaceutical conjugate compositions and uses thereof. In one aspect, provided herein are conjugates that comprise a monocyclic peptide of 5 to 40 amino acid residues and a metal chelator configured to bind with a radionuclide. In some embodiments, the monocyclic peptide is cyclized by a non-disulfide bond. In some embodiments, the monocyclic peptide does not comprise any non-disulfide bond. The monocyclic peptide can be configured to bind with a structure on a cell. Further provided herein are methods of treating cancer by administering the described conjugates and compositions.

Abstract: A floating-island type artificial wetland treatment system based on a lake center platform is provided. The system includes a lake center platform, a water inflow sub-system including water inflow filled columns, a water drainage sub-system including water drainage filled columns, a water collection and distribution sub-system including water collection tanks, and a platform wetland sub-system; the water drainage filled column is located in a center of a bottom of the lake center platform; the plurality of water inflow filled columns are uniformly distributed at edges of the bottom of the lake center platform with the water drainage filled column as a center; the platform wetland sub-system is located in a center region of an upper surface of the lake center platform; and the plurality of water collection tanks are uniformly distributed at edges of the upper surface of the lake center platform with the platform wetland sub-system as a center.

Abstract: An appliance includes an outer wrapper, an inner liner, a trim breaker having a channel that receives at least one of a wrapper edge of the outer wrapper and a liner edge of the inner liner, and a composite encapsulation system that hermetically seals an insulating cavity defined between the outer wrapper and the inner liner. The composite encapsulation system includes a base adhesive and an outer adhesive, wherein the base adhesive defines a structural adhesive component and the outer adhesive defines a sealing adhesive component.