Patents by Inventor Liudmila Cebotaru

Liudmila Cebotaru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MODULATORS FOR TREATING AUTOSOMAL RESESSIVE POLYCYSTIC KIDNEY DISEASE
    Publication number: 20220331301
    Abstract: Cystic fibrosis transmembrane conductance regulator (CFTR) modulators rescue several processes malfunctioning in autosomal recessive polycystic kidney disease (ARPKD), including increasing FPC and CFTR protein levels, increasing CFTR at the basolateral membrane and at the cilia, reducing cAMP, reducing ER Ca2+ release in response to thapsigargin, and reducing Hsp70, Hsp90, and Aha1. CFTR modulators also correct the trafficking of CFTR. All these maneuvers, either individually or in combination, reduce cyst growth in liver and improve liver, renal, pancreatic and lung function.
    Type: Application
    Filed: February 17, 2022
    Publication date: October 20, 2022
    Inventor: Liudmila Cebotaru
  • CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MODULATORS FOR TREATING AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE
    Publication number: 20220193053
    Abstract: Described are methods of treating cystic kidney disease. Also disclosed are methods of reducing the size and/or number of cysts in autosomal dominant polycystic kidney disease.
    Type: Application
    Filed: December 27, 2021
    Publication date: June 23, 2022
    Inventor: Liudmila Cebotaru
  • CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MODULATORS FOR TREATING AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE
    Publication number: 20220133702
    Abstract: Described are methods of treating cystic kidney disease. Also disclosed are methods of reducing the size and/or number of cysts in autosomal dominant polycystic kidney disease.
    Type: Application
    Filed: October 28, 2021
    Publication date: May 5, 2022
    Inventor: Liudmila Cebotaru
  • CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MODULATORS FOR TREATING AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE
    Publication number: 20200289482
    Abstract: Described are methods of treating cystic kidney disease. Also disclosed are methods of reducing the size and/or number of cysts in autosomal dominant polycystic kidney disease.
    Type: Application
    Filed: June 21, 2018
    Publication date: September 17, 2020
    Inventor: Liudmila Cebotaru
  • Compositions for treating cystic fibrosis
    Patent number: 8137962
    Abstract: The invention relates to compositions and methods of treating cystic fibrosis. More specifically, this invention relates to the use the AAV vectors and constructs to provide gene therapy to cystic fibrosis patients.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: March 20, 2012
    Assignees: University of Florida Research Foundation, The Johns Hopkins University
    Inventors: Terence R. Flotte, Jeffrey R. Sirninger, William B. Guggino, Liudmila Cebotaru, Christian Müller
  • Compositions and methods for treating cystic fibrosis
    Publication number: 20080003204
    Abstract: The invention relates to compositions and methods of treating cystic fibrosis. More specifically, this invention relates to the use the AAV vectors and constructs to provide gene therapy to cystic fibrosis patients.
    Type: Application
    Filed: March 2, 2007
    Publication date: January 3, 2008
    Inventors: Terence Flotte, Jeffrey Sirninger, William Guggino, Liudmila Cebotaru, Christian Muller