Patents by Inventor Liusheng Zhu

Liusheng Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic carboxylic acid derivatives useful for treating metabolic disorders
    Publication number: 20070244155
    Abstract: Compounds having the general formula I and/or the general formula II are useful, for example, for treating metabolic disorders in a subject where the variables are provided herein. Compositions and methods for using the compounds for preparing medicaments and for treating metabolic disorders such as, for instance, type II diabetes are disclosed.
    Type: Application
    Filed: March 13, 2007
    Publication date: October 18, 2007
    Applicant: AMGEN INC.
    Inventors: Rajiv Sharma, Michelle Akerman, Mario Cardozo, Jonathan Houze, An-Rong Li, Jinquian Liu, Jiwen Liu, Zhihua Ma, Julio Medina, Michael Schmitt, Ying Sun, Yingcai Wang, Zhongyu Wang, Liusheng Zhu
  • CXCR3 antagonists
    Publication number: 20070149557
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment of conditions and diseases mediated by a chemokine receptor. In particular, the compounds of the invention modulate the CXCR3 chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.
    Type: Application
    Filed: November 21, 2006
    Publication date: June 28, 2007
    Applicant: Amgen Inc.
    Inventors: Tassie Collins, Julio Medina, Feng Xu, Liusheng Zhu
  • Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
    Publication number: 20070142384
    Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
    Type: Application
    Filed: February 24, 2005
    Publication date: June 21, 2007
    Applicant: AMGEN INC.
    Inventors: Michelle Akerman, Jonathan Houze, Daniel Lin, Jinqian Liu, Jiwen Liu, Jian Luo, Zhihua Ma, Julio Medina, Wei Qiu, Jeffrey Reagan, Rajiv Sharma, Michael Schmitt, Stephen Shuttleworth, Ying Sun, Yingcai Wang, Jian Zhang, Liusheng Zhu
  • Conformationally constrained 3-(4-hydroxy-phenyl)-substituted-propanoic acids useful for treating metabolic disorders
    Publication number: 20070066647
    Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, L2, M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
    Type: Application
    Filed: September 8, 2006
    Publication date: March 22, 2007
    Applicant: AMGEN ING.
    Inventors: Michelle Akerman, Sean Brown, Jonathan Houze, Jinqian Liu, Jiwen Liu, Zhihua Ma, Julio Medina, Wei Qiu, Michael Schmitt, Rajiv Sharma, Yingcai Wang, Liusheng Zhu
  • CCR4 antagonists
    Patent number: 7144903
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment of chemokine receptor-mediated conditions and diseases. In particular, the invention provides compounds which modulate CCR4 function or a CCR4-mediated response. The subject compounds and compositions are useful for the treatment or prevention of inflammatory conditions and diseases.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: December 5, 2006
    Assignee: Amgen Inc.
    Inventors: Tassie Collins, Hossen Mahmud, Jonathan Houze, Alan Xi Huang, Julio C. Medina, Xuemei Wang, Feng Xu, Qingge Xu, Liusheng Zhu
  • Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
    Publication number: 20060270724
    Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and R1 has the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.
    Type: Application
    Filed: May 17, 2006
    Publication date: November 30, 2006
    Applicant: AMGEN INC
    Inventors: Jonathan Houze, Jiwen Liu, Zhihua Ma, Julio Medina, Michael Schmitt, Rajiv Sharma, Ying Sun, Yingcai Wang, Liusheng Zhu
  • CXCR3 antagonists
    Patent number: 7067662
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.
    Type: Grant
    Filed: September 21, 2004
    Date of Patent: June 27, 2006
    Assignee: Amgen SF, LLC
    Inventors: Julio C. Medina, Michael G. Johnson, An-Rong Li, Jiwen Liu, Alan Xi Huang, Liusheng Zhu, Andrew P. Marcus
  • Substituted Quinazolin-4(3H)-one compounds, compositions, and methods for their use
    Patent number: 7053215
    Abstract: Compounds are provided that have the formula: where X, A4, Ra, R1, R2, R3, R4, R14, L and Q are as described herein. These compounds are useful, for example, as modulators of a chemokine receptor and for treatment of inflammatory and immunoregulatory disorders and diseases. Pharmaceutical compositions and methods of using these compounds for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes, are also provided.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: May 30, 2006
    Assignee: Amgen SF, LLC
    Inventors: Julio C. Medina, Michael G. Johnson, An-Rong Li, Jiwen Liu, Alan Xi Huang, Liusheng Zhu, Andrew P. Marcus
  • Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
    Publication number: 20060004012
    Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
    Type: Application
    Filed: February 25, 2005
    Publication date: January 5, 2006
    Inventors: Michelle Akerman, Jonathan Houze, Daniel Lin, Jiwen Liu, Jian Luo, Julio Medina, Wei Qiu, Jeffrey Reagan, Rajiv Sharma, Michael Schmitt, Stephen Shuttleworth, Ying Sun, Yingcai Wang, Jian Zhang, Liusheng Zhu
  • STAT modulators
    Publication number: 20050101540
    Abstract: The present invention provides compounds, compositions and methods for the inhibition or treatment of conditions or disorders modulated by the STAT transcription factors, particularly STAT4 and STAT6. Additionally, the compounds are useful for the diagnosis of conditions dependent on STAT signaling.
    Type: Application
    Filed: December 14, 2004
    Publication date: May 12, 2005
    Applicant: Amgen Inc.
    Inventors: Alan Huang, Jiwen Liu, Julio Medina, Xuemei Wang, Feng Xu, Liusheng Zhu
  • STAT modulators
    Patent number: 6884782
    Abstract: The present invention provides compounds, compositions and methods for the inhibition or treatment of conditions or disorders modulated by the STAT transcription factors, particularly STAT4 and STAT6. Additionally, the compounds are useful for the diagnosis of conditions dependent on STAT signaling.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: April 26, 2005
    Assignee: Amgen Inc.
    Inventors: Alan Huang, Jiwen Liu, Julio Medina, Xuemei Wang, Feng Xu, Liusheng Zhu
  • CXCR3 antagonists
    Publication number: 20050075333
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.
    Type: Application
    Filed: September 21, 2004
    Publication date: April 7, 2005
    Inventors: Julio Medina, Michael Johnson, An-Rong Li, Jiwen Liu, Alan Huang, Liusheng Zhu, Andrew Marcus
  • CXCR3 antagonists
    Publication number: 20030069234
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.
    Type: Application
    Filed: June 6, 2002
    Publication date: April 10, 2003
    Inventors: Julio C. Medina, Michael G. Johnson, An-Rong Li, Jiwen Liu, Alan Xi Huang, Liusheng Zhu, Andrew P. Marcus
  • CXCR3 antagonists
    Publication number: 20030055054
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.
    Type: Application
    Filed: August 29, 2002
    Publication date: March 20, 2003
    Applicant: Tularik, Inc.
    Inventors: Julio C. Medina, Michael G. Johnson, An-Rong Li, Jiwen Liu, Alan Xi Huang, Liusheng Zhu, Andrew P. Marcus
  • Ccr4 antagonists
    Publication number: 20030018022
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment of chemokine receptor-mediated conditions and diseases. In particular, the invention provides compounds which modulate CCR4 function or a CCR4-mediated response. The subject compounds and compositions are useful for the treatment or prevention of inflammatory conditions and diseases.
    Type: Application
    Filed: May 22, 2002
    Publication date: January 23, 2003
    Applicant: Tularik Inc.
    Inventors: Tassie Collins, Hossen Mahmud, Jonathan Houze, Alan Xi Huang, Julio C. Medina, Xuemei Wang, Feng Xu, Qingge Xu, Liusheng Zhu
  • CXCR3 antagonists
    Publication number: 20020169159
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.
    Type: Application
    Filed: December 11, 2001
    Publication date: November 14, 2002
    Applicant: Tularik Inc.
    Inventors: Julio C. Medina, Michael G. Johnson, An-Rong Li, Jiwen Liu, Alan Xi Huang, Liusheng Zhu, Andrew P. Marcus
  • STAT modulators
    Publication number: 20020151504
    Abstract: The present invention provides compounds, compositions and methods for the inhibition or treatment of conditions or disorders modulated by the STAT transcription factors, particularly STAT4 and STAT6. Additionally, the compounds are useful for the diagnosis of conditions dependent on STAT signaling.
    Type: Application
    Filed: November 7, 2001
    Publication date: October 17, 2002
    Applicant: Tularik Inc.
    Inventors: Alan Huang, Jiwen Liu, Julio Medina, Xuemei Wang, Feng Xu, Liusheng Zhu
  • LXR modulators
    Patent number: 6316503
    Abstract: The invention provides compounds, compositions and methods for modulating the effects of LXR in a cell. The compounds and compositions are useful both as diagnostic indicators of LXR function and as pharmacologically active agents. The compounds and compositions find particular use in the treatment of disease states associated with cholesterol metabolism, particularly atherosclerosis and hypercholesterolemia.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: November 13, 2001
    Assignee: Tularik Inc.
    Inventors: Leping Li, Julio C. Medina, Kevin Lustig, Bei Shan, Hirohiko Hasegawa, Serena T. Cutler, Jiwen Liu, Liusheng Zhu