Patents by Inventor Liv Bode

Liv Bode has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detecting acute Borna disease virus (BDV) infections, and diagnostic kit therefor, in particular in combination with methods for distinguishing acute from chronic and latent BDV infections, and diagnostic kits therefor
    Patent number: 11835521
    Abstract: One aspect of the present invention is directed to a method for detecting acute Borna Disease Virus (BDV) infections. According to the invention, the presence of heterodimers of p24 BDV phosphoprotein and p40 BDV nucleoprotein in a sample is determined by means of antibodies of both proteins using a sandwich ELISA. The invention also relates to a diagnostic kit for a sandwich ELISA for detecting mute BDV infections. Said kit uses a antibody of p24 BDV phosphoprotein and a second primary antibody of p40 BDV nucleoprotein, at least one reporter-molecule-labelled secondary antibody, means for immobilising a primary antibody on a surface, and instructions for carrying out the method according to the invention. The invention also relates to the combination of the method according to the invention and the new diagnostic kit with known methods for detecting circulating immune complexes (CIC) and antibodies.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: December 5, 2023
    Inventors: Hanns Ludwig, Liv Bode
  • METHOD FOR DETECTING ACUTE BORNA DISEASE VIRUS (BDV) INFECTIONS, AND DIAGNOSTIC KIT THEREFOR, IN PARTICULAR IN COMBINATION WITH METHODS FOR DISTINGUISHING ACUTE FROM CHRONIC AND LATENT BDV INFECTIONS, AND DIAGNOSTIC KITS THEREFOR
    Publication number: 20200271649
    Abstract: One aspect of the present invention is directed to a method for detecting acute Borna Disease Virus (BDV) infections. According to the invention, the presence of heterodimers of p24 BDV phosphoprotein and p40 BDV nucleoprotein in a sample is determined by means of antibodies of both proteins using a sandwich ELISA. The invention also relates to a diagnostic kit for a sandwich ELISA for detecting mute BDV infections. Said kit uses a antibody of p24 BDV phosphoprotein and a second primary antibody of p40 BDV nucleoprotein, at least one reporter-molecule-labelled secondary antibody, means for immobilising a primary antibody on a surface, and instructions for carrying out the method according to the invention. The invention also relates to the combination of the method according to the invention and the new diagnostic kit with known methods for detecting circulating immune complexes (CIC) and antibodies.
    Type: Application
    Filed: September 11, 2018
    Publication date: August 27, 2020
    Inventors: Hanns LUDWIG, Liv BODE
  • Process for detecting Borna disease virus (BDV) infections
    Patent number: 6403301
    Abstract: The invention allows, for the first time, to (almost) perfectly detect the various phases of a BDV infection in all species by combining a newly discovered test parameter, the circulating immune complexes (CICs) in the blood plasma, with already known parameters, antigen (AG) in white blood cells and antibodies (AK) in the plasma. All three parameters can be determined from a single blood sample. The detection of BDV-specific CICs described for the first time by the invention as the only infection markers with long-time persistence allows both the detection of healthy carriers (latent infections) and the evaluation of the development of the infection and of therapy results in the case of diseased individuals.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: June 11, 2002
    Inventors: Hans Ludwig, Liv Bode
  • USE OF ADAMANTANE AMINES OR STRUCTURALLY SIMILAR COMPOUNDS FOR COMBATING BORNA DISEASE VIRUS AND FOR THE PREVENTION AND TREATMENT OF AFFECTIVE DISEASES AND OTHER DISORDERS ASSOCIATED WITH BDV INFECTIONS IN HUMANS AND ANIMALS
    Patent number: 6384083
    Abstract: The invention concerns the use of 1-adamantane amines (amantadines) or structurally similar compounds for combating borna disease virus infections and for treating affective diseases and disorders associated with borna disease virus infections in humans and animals. The use of these substrates results in rapid and lasting elimination of the symptoms and signs and in the suppression of the virus activity.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: May 7, 2002
    Inventors: Hanns Ludwig, Detlef Dietrich, Hinderk M. Emrich, Liv Bode