Patents by Inventor Livia Schiavinato Eberlin

Livia Schiavinato Eberlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240219410
    Abstract: The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis.
    Type: Application
    Filed: December 22, 2023
    Publication date: July 4, 2024
    Inventors: Robert Graham Cooks, Livia Schiavinato Eberlin, Christina Ramires Ferreira, Allison Lisa Dill, Demian R. Ifa
  • Patent number: 11903707
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: February 20, 2024
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • Publication number: 20240011999
    Abstract: Methods for detecting lung cancer cells, or lung cancer subtypes, by measuring levels of metabolites are provided.
    Type: Application
    Filed: August 27, 2021
    Publication date: January 11, 2024
    Inventors: Livia Schiavinato EBERLIN, Erik CRESSMAN, Alena V. BENSUSSAN, John LIN, Chunxiao GUO, Savitri KRISHNAMURTHY
  • Patent number: 11860172
    Abstract: The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis. Due to the use of a liquid phase that does not destroy native tissue morphology during analysis, a subsequent staining technique can be performed on the tissue sample and an overlaid image can be produced of a mass spectral image and a staining image.
    Type: Grant
    Filed: May 26, 2021
    Date of Patent: January 2, 2024
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Livia Schiavinato Eberlin, Christina Ramires Ferreira, Allison Lisa Dill, Demian R. Ifa
  • Publication number: 20230386815
    Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
    Type: Application
    Filed: July 28, 2023
    Publication date: November 30, 2023
    Inventors: Livia Schiavinato EBERLIN, Thomas MILNER, Jialing ZHANG, John LIN, John RECTOR, Nitesh KATTA, Aydin ZAHEDIVASH
  • Patent number: 11756778
    Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
    Type: Grant
    Filed: December 30, 2021
    Date of Patent: September 12, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Livia Schiavinato Eberlin, Thomas Milner, Jialing Zhang, John Lin, John Rector, Nitesh Katta, Aydin Zahedivash
  • Patent number: 11737671
    Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for minimally invasive collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: August 29, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Livia Schiavinato Eberlin, Thomas Milner, Jialing Zhang, Noah Giese, Nitesh Katta
  • Publication number: 20230167478
    Abstract: In a general aspect, microorganisms [e.g., bacteria, etc.) are identified and detected. In some examples, a liquid solvent is supplied through a first channel of a sampling probe to an internal reservoir of the sampling probe; a fixed volume of the liquid solvent in the internal reservoir is held in direct contact with a sample surface for a period of time to form a liquid analyte; gas is supplied to the internal reservoir through a second channel of the sampling probe; the liquid analyte is extracted from the internal reservoir through a third channel of the sampling probe; the liquid analyte is transferred to a mass spectrometer; the mass spectrometer processes the liquid analyte to produce mass spectrometry data; and the mass spectrometry data are analyzed to detect and identify a microorganism [e.g., acteria, fungi, or another type of microorganism) present at the sample surface.
    Type: Application
    Filed: April 27, 2021
    Publication date: June 1, 2023
    Inventors: Livia SCHIAVINATO EBERLIN, Sydney POVILAITIS, Marta SANS ESCOFET, Jialing ZHANG, Lindsey M. KIRKPATRICK
  • Publication number: 20230170202
    Abstract: In a general aspect, chemical compounds (e.g., drugs, agrochemicals, and explosives) are detected. In some examples, a chemical detection system includes a container, an ionization system, a mass spectrometer, one or more computer systems, a sampling probe, and a control system. The sampling probe is configured to receive a liquid solvent from the container; to hold a fixed volume of the liquid solvent in direct contact with a sample surface for a period of time to form an analyte in the sampling probe; and to deliver the analyte to the ionization system. The ionization system is configured to ionize the analyte. The mass spectrometer is configured to produce mass spectrometry data by processing the ionized analyte provided by the ionization system. The one or more computer systems are configured to analyze the mass spectrometry data to detect a chemical compound present on the sample surface.
    Type: Application
    Filed: April 27, 2021
    Publication date: June 1, 2023
    Inventors: Livia SCHIAVINATO EBERLIN, Jialing ZHANG, Clara L. FEIDER, Abigail N. GATMAITAN
  • Publication number: 20230050396
    Abstract: In a general aspect, a swab sample is analyzed, for example, to test for disease. In some examples, a swab head of a swab sample is inserted through an opening into an internal reservoir of a sampling device. The sampling device includes the opening, an inlet channel, an outlet channel, and the internal reservoir. The internal reservoir is in fluid communication with the inlet channel, the outlet channel, and the opening. A liquid solvent is supplied to the swab head in the internal reservoir via the inlet channel of the sampling device. The swab head is held in the liquid solvent for a period of time to form an analyte in the internal reservoir. The analyte is extracted from the internal reservoir via the outlet channel of the sampling device. The analyte is transferred to and processed by a mass spectrometer to obtain mass spectrometry data.
    Type: Application
    Filed: October 27, 2022
    Publication date: February 16, 2023
    Applicants: MS Pen Technologies, Incorporated, Board of Regents, The University of Texas System
    Inventors: Livia Schiavinato Eberlin, Shannon D. Green, Kyana Garza, Sydney Cordano Povilaitis, Michael Keating, Jialing Zhang, James Suliburk
  • Publication number: 20220310378
    Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
    Type: Application
    Filed: December 30, 2021
    Publication date: September 29, 2022
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Livia Schiavinato EBERLIN, Thomas MILNER, Jialing ZHANG, John LIN, John RECTOR, Nitesh KATTA, Aydin ZAHEDIVASH
  • Publication number: 20220296102
    Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for minimally invasive collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
    Type: Application
    Filed: November 5, 2021
    Publication date: September 22, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Livia Schiavinato Eberlin, Thomas Milner, Jialing Zhang, Noah Giese, Nitesh Katta
  • Publication number: 20220265172
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Application
    Filed: March 11, 2022
    Publication date: August 25, 2022
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • Publication number: 20220268784
    Abstract: In a general aspect, methods and devices are provided for using mass spectrometry to identify endometriosis. In some aspects, a fixed or discrete volume of a solvent is applied to a tissue site including possible endometriosis tissue. The applied solvent is collected to obtain a liquid sample. The liquid sample is subjected to mass spectrometry analysis. The liquid sample is collected from a tissue site in vivo during a medical procedure. The mass spectrometry data are analyzed to identify whether the tissue site comprises endometriosis.
    Type: Application
    Filed: December 6, 2021
    Publication date: August 25, 2022
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Livia Schiavinato Eberlin, Michael T. Breen, Jialing Zhang, Clara L. Feider, John Lin, Thomas Milner
  • Patent number: 11397189
    Abstract: The invention generally relates to methods for analyzing a metabolite level in a sample. In certain embodiments, methods of the invention may involve obtaining a sample, analyzing the sample using a mass spectrometry technique to determine a level of at least one metabolite in the sample, and correlating the metabolite level with an originating source of the sample, thereby analyzing the sample.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: July 26, 2022
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Kevin Scott Kerian, Alan Keith Jarmusch, Ahmed Mohamed Hamid, Livia Schiavinato Eberlin
  • Publication number: 20220196697
    Abstract: Methods and apparatus are provided for cleaning or exchanging medical devices. Certain embodiments may include a cassette comprising a plurality of medical devices, where the orientation of the cassette can be changed while the cassette is coupled to a processing instrument.
    Type: Application
    Filed: July 23, 2021
    Publication date: June 23, 2022
    Inventors: Livia SCHIAVINATO EBERLIN, Thomas MILNER, Jialing ZHANG, Noah GIESE, John LIN, Jeffrey R. KUHN, James SULIBURK, Nitesh KATTA
  • Patent number: 11304637
    Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: April 19, 2022
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zheng Ouyang, Chien-hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
  • Patent number: 11239065
    Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: February 1, 2022
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Livia Schiavinato Eberlin, Thomas Milner, Jialing Zhang, John Lin, John Rector, Nitesh Katta, Aydin Zahedivash
  • Publication number: 20210356480
    Abstract: The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis.
    Type: Application
    Filed: May 26, 2021
    Publication date: November 18, 2021
    Inventors: Robert Graham Cooks, Livia Schiavinato Eberlin, Christina Ramires Ferreira, Allison Lisa Dill, Demian R. Ifa
  • Publication number: 20210343515
    Abstract: Method and devices are provided for imaging a surface, such as a biological tissue sample, by mass spectrometry. In certain aspects, devices of the embodiments allow for the placement and collection of a plurality of spatially separated liquid droplets on a sample and delivery of the droplets with extracted sample analytes for mass spectrometry analysis.
    Type: Application
    Filed: June 8, 2018
    Publication date: November 4, 2021
    Inventors: Livia Schiavinato EBERLIN, Marta Sans ESCOFET, Bryan R. WYGANT, Jialing ZHANG, C. Buddie MULLINS