Patents by Inventor Livia Soares Zaramela

Livia Soares Zaramela has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210062171
    Abstract: The present disclosure relates to novel sialidase enzymes having a preference for cleaving N-glycolylneuraminic acid (Neu5Gc) from glycoconjugates over cleaving N-acetylneuraminic acid (Neu5Ac). The present disclosure further provides the polypeptide of such novel sialidase and its catalytic pockets; the recombinant host cells expressing the same, as well as the enzymatic, pharmaceutical, and consumable compositions comprising such novel sialidases. Probiotic compositions comprising a bacterium that expresses the sialidase having a preference for Neu5Gc over Neu5Ac, and methods for removing Neu5Gc from consumable products are also provided. Also disclosed are methods for treating or preventing various diseases, disorders, and inflammatory conditions in a subject using the novel sialidases.
    Type: Application
    Filed: August 28, 2020
    Publication date: March 4, 2021
    Applicant: The Regents of the University of California
    Inventors: Karsten Zengler, Ajit Varki, Frederico Da Silva, Sandra Diaz, Cameron Martino, Geoffrey Chang, Steven Rees, Livia Soares Zaramela