Patents by Inventor Livnat Bangio

Livnat Bangio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating glioblastoma GBM
    Patent number: 10369196
    Abstract: Methods of treating a malignant glioma in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a viral vector comprising: (i) a first polynucleotide sequence encoding a Fas-chimera (Fas-c), said first polynucleotide sequence comprising SEQ ID NOs: 2 and 3; and (ii) a second polynucleotide sequence encoding an endothelial cell-specific promoter or a periendothelial cell-specific promoter.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: August 6, 2019
    Assignee: Vascular Biogenics Ltd.
    Inventors: Yael Cohen, Livnat Bangio, Andrew J. Brenner, Eyal Breitbart
  • Methods for use of a specific anti-angiogenic adenoviral agent
    Patent number: 9567605
    Abstract: Anti-angiogenic adenovirus vectors, and therapeutic use thereof are provided, and more particularly, but not exclusively, clinical protocols for treatment of solid tumors in patients with an Ad5-PPE-1-3X-fas-chimera adenovirus vector.
    Type: Grant
    Filed: January 5, 2011
    Date of Patent: February 14, 2017
    Assignee: Vascular Biogenics Ltd.
    Inventors: Yael Cohen, Naamit Sher, Erez Feige, Livnat Bangio, Eyal Breitbart
  • Endothelial cell-specific polynucleotides and use thereof
    Patent number: 9403887
    Abstract: An isolated polynucleotide is disclosed comprising a nucleic acid sequence encoding a polypeptide having an amino acid sequence of HIF-1alpha, the polypeptide being stably expressed and constitutively active. Isolated polypeptides encoded by same are also disclosed and uses thereof.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: August 2, 2016
    Assignee: Vascular Biogenics Ltd.
    Inventors: Eyal Breitbart, Livnat Bangio, Reshef Tal
  • Endothelial Cell-Specific Polynucleotides and Use Thereof
    Publication number: 20150111957
    Abstract: An isolated polynucleotide is disclosed comprising a nucleic acid sequence encoding a polypeptide having an amino acid sequence of HIF-1alpha, the polypeptide being stably expressed and constitutively active. Isolated polypeptides encoded by same are also disclosed and uses thereof.
    Type: Application
    Filed: September 24, 2014
    Publication date: April 23, 2015
    Inventors: Eyal Breitbart, Livnat Bangio, Reshef Tal
  • Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
    Patent number: 8835398
    Abstract: Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: September 16, 2014
    Assignee: Vascular Biogenics Ltd.
    Inventors: Dror Harats, Shoshana Greenberger, Eyal Breitbart, Livnat Bangio, Michael Peled
  • PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME FOR REGULATION OF ANGIOGENESIS
    Publication number: 20140155467
    Abstract: Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
    Type: Application
    Filed: October 21, 2013
    Publication date: June 5, 2014
    Applicant: VASCULAR BIOGENICS LTD.
    Inventors: Dror HARATS, Shoshana GREENBERGER, Eyal BREITBART, Livnat BANGIO, Michael PELED
  • Compositions and Methods for Treating Glioblastoma GBM
    Publication number: 20130303595
    Abstract: Methods of treating a malignant glioma in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a viral vector comprising: (i) a first polynucleotide sequence encoding a Fas-chimera (Fas-c), said first polynucleotide sequence comprising SEQ ID NOs: 2 and 3; and (ii) a second polynucleotide sequence encoding an endothelial cell-specific promoter or a periendothelial cell-specific promoter.
    Type: Application
    Filed: March 14, 2013
    Publication date: November 14, 2013
    Inventors: YAEL COHEN, LIVNAT BANGIO, ANDREW J. BRENNER, EYAL BREITBART
  • Methods of Producing Adenovirus Vectors and Viral Preparations Generated Thereby
    Publication number: 20130295053
    Abstract: The present invention, in some embodiments thereof, relates to methods of producing adenoviruses such as pro- and anti-angiogenic adenovirus vectors and preparations generated there by. Particularly, in some embodiments, the viral vectors comprise a heterologous pro- or anti-angiogenic gene under the transcriptional control of the murine pre-proendothelin promoter (e.g. PPE-1-3X), for targeted expression of in angiogenic endothelium.
    Type: Application
    Filed: March 14, 2013
    Publication date: November 7, 2013
    Inventors: Livnat BANGIO, Naamit Sher, Eyal Breitbart
  • Methods for Use of a Specific Anti-Angiogenic Adenoviral Agent
    Publication number: 20130280216
    Abstract: Anti-angiogenic adenovirus vectors, and therapeutic use thereof are provided, and more particularly, but not exclusively, clinical protocols for treatment of solid tumors in patients with an Ad5-PPE-1-3X-fas-chimera adenovirus vector.
    Type: Application
    Filed: March 12, 2013
    Publication date: October 24, 2013
    Inventors: Yael COHEN, Naamit Sher, Erez Feige, Livnat Bangio, Eyal Breitbart
  • Methods for Use of a Specific Anti-Angiogenic Adenoviral Agent
    Publication number: 20130280217
    Abstract: Anti-angiogenic adenovirus vectors, and therapeutic use thereof are provided, and more particularly, but not exclusively, clinical protocols for treatment of solid tumors in patients with an Ad5-PPE-1-3X-fas-chimera adenovirus vector.
    Type: Application
    Filed: March 12, 2013
    Publication date: October 24, 2013
    Inventors: YAEL COHEN, NAAMIT SHER, EREZ FEIGE, LIVNAT BANGIO, EYAL BREITBART
  • Compositions and Methods for Treating Glioblastoma GBM
    Publication number: 20130209450
    Abstract: Methods of treating a malignant glioma in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a viral vector comprising: (i) a first polynucleotide sequence encoding a Fas-chimera (Fas-c), said first polynucleotide sequence comprising SEQ ID NOs: 2 and 3; and (ii) a second polynucleotide sequence encoding an endothelial cell-specific promoter or a periendothelial cell-specific promoter.
    Type: Application
    Filed: January 5, 2011
    Publication date: August 15, 2013
    Inventors: Yael Cohen, Livnat Bangio, Andrew J. Brenner, Eyal Breitbart
  • Methods of Producing Adenovirus Vectors and Viral Preparations Generated Thereby
    Publication number: 20130052165
    Abstract: The present invention, in some embodiments thereof, relates to methods of producing adenoviruses such as pro- and anti-angiogenic adenovirus vectors and preparations generated thereby. Particularly, in some embodiments, the viral vectors comprise a heterologous pro- or anti-angiogenic gene under the transcriptional control of the murine pre-proendothelin promoter (e.g. PPE-1-3X), for targeted expression of in angiogenic endothelium.
    Type: Application
    Filed: January 12, 2011
    Publication date: February 28, 2013
    Inventors: Livnat Bangio, Naamit Sher, Eyal Breitbart
  • Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis
    Publication number: 20130011367
    Abstract: Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
    Type: Application
    Filed: July 13, 2012
    Publication date: January 10, 2013
    Applicant: Vascular Biogenics, Ltd.
    Inventors: Dror Harats, Shoshana Greenberger, Eyal Breitbart, Livnat Bangio, Michael Peled
  • Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
    Patent number: 8206743
    Abstract: Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: June 26, 2012
    Assignee: Vascular Biogenics Ltd.
    Inventors: Dror Harats, Shoshana Greenberger, Eyal Breitbart, Livnat Bangio, Michael Peled
  • POLYPEPTIDES AND POLYNUCLEOTIDES ENCODING SAME AND USE THEREOF IN THE TREATMENT OF MEDICAL CONDITIONS ASSOCIATED WITH ISCHEMIA
    Publication number: 20110319479
    Abstract: An isolated polynucleotide is disclosed comprising a nucleic acid sequence encoding a polypeptide having an amino acid sequence of HIF-1 alpha, the polypeptide being stably expressed and constitutively active. Isolated polypeptides encoded by same are also disclosed and uses thereof.
    Type: Application
    Filed: June 20, 2011
    Publication date: December 29, 2011
    Applicant: VASCULAR BIOGENICS LTD.
    Inventors: EYAL BREITBART, LIVNAT BANGIO, RESHEF TAL
  • Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
    Patent number: 8071740
    Abstract: Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
    Type: Grant
    Filed: November 14, 2004
    Date of Patent: December 6, 2011
    Assignee: Vascular Biogenics Ltd.
    Inventors: Dror Harats, Shoshana Greenberger, Eyal Breitbart, Livnat Bangio, Michael Peled
  • Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
    Patent number: 8039261
    Abstract: Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: October 18, 2011
    Assignee: Vascular Biogenics Ltd.
    Inventors: Dror Harats, Shoshana Greenberger, Eyal Breitbart, Livnat Bangio, Michael Peled
  • PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME FOR REGULATION OF ANGIOGENESIS
    Publication number: 20110207985
    Abstract: Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
    Type: Application
    Filed: May 2, 2011
    Publication date: August 25, 2011
    Applicant: Vascular Biogenics Ltd.
    Inventors: Dror HARATS, Shoshana Greenberger, Eyal Breitbart, Livnat Bangio, Michael Peled
  • PROMOTERS EXHIBITING ENDOTHELIAL CELL SPECIFICITY AND METHODS OF USING SAME FOR REGULATION OF ANGIOGENESIS
    Publication number: 20110129511
    Abstract: Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by aberrant neovascularization or cell growth are disclosed.
    Type: Application
    Filed: February 1, 2011
    Publication date: June 2, 2011
    Applicant: Vascular Biogenics Ltd.
    Inventors: Dror HARATS, Shoshana Greenberger, Eyal Breibart, Livnat Bangio, Michael Peled
  • POLYPEPTIDES AND POLYNUCLEOTIDES ENCODING SAME AND USE THEREOF IN THE TREATMENT OF MEDICAL CONDITIONS ASSOCIATED WITH ISCHEMIA
    Publication number: 20100298226
    Abstract: An isolated polynucleotide is disclosed comprising a nucleic acid sequence encoding a polypeptide having an amino acid sequence of HIF-1alpha, the polypeptide being stably expressed and constitutively active. Isolated polypeptides encoded by same are also disclosed and uses thereof.
    Type: Application
    Filed: July 31, 2007
    Publication date: November 25, 2010
    Applicant: Vascular Biogenics Ltd.
    Inventors: Eyal Breitbart, Livnat Bangio