Abstract: The present invention belongs to the field of medicinal chemistry and relates to a class of substituted tricyclic compounds as PRMT5 inhibitors and the use thereof. Specifically, the present invention provides a compound represented by formula (A) or an isomer, pharmaceutically acceptable salt, solvate, crystal or prodrug thereof, a preparation method therefor, a pharmaceutical composition containing the compounds, and the use of the compounds or the composition for treating a disease mediated by PRMT5. The compounds of the present invention show significant inhibitory activity on PRMT5.

Abstract: This disclosure provides an unmanned survey vessel with an anti-overturning structure and an anti-overturning method of same, and relates to the anti-overturning technique field of unmanned survey vessels. The unmanned survey vessel includes a vessel body and a plurality of buoys. The vessel body is a hollow frame of which a middle is provided with a discharge space. An uptight rod is vertically fixed at an upper-end of the tail part of the vessel body. A supporting beam is horizontally fixed at an upper-end of the upright rod. The supporting beam extends to a bow of the vessel. A rectangular notch is formed in one end, close to the bow, of the supporting beam. One end close to the bow inside the rectangular notch is rotatably provided with a guide rod through a pin shaft. The plurality of buoys are equally divided into two groups which are adjustably arranged on two side walls in the advancing direction of the vessel body respectively.

Abstract: An easy-to-assemble mounting rack for a deformation detection device for a steel structure and an assembling method thereof are provided. The easy-to-assemble mounting rack includes mounting parts including a back mounting plate, an operating rod, an adjusting seat, a ball-shaped block and an upright rod. The upright rod is vertically fixed at the bottom end face of the adjusting seat. A ball-shaped hole is formed in the adjusting seat. The ball-shaped block is rotatably embedded in the ball-shaped hole. A plug-in hole is formed in a radial direction of the ball-shaped block. One end of the operating rod slidably penetrates through the plug-in hole and is detachably connected with the back mounting plate. Screw holes directly opposite to the mounting holes of the deformation detection device are formed on the back mounting plate. The other end of the operating rod is fixedly sleeved with a counterweight plate.

Abstract: Provided are a clip assembly and a refrigerating and freezing device provided with same, wherein the clip assembly comprises a fixed member used for fixing to the refrigerating and freezing device, clips, a clip storage box, and a movable member. The clip storage box has a storage cavity used for storing the clips. The clips may be stored and organized, and are convenient for users to access. Moreover, the movable member has an accommodating space that accommodates the clip storage box. The clip storage box is detachably accommodated in the accommodating space, and the movable member is configured to operably rotate to the side away from the fixed member, which facilitates the removal of the clip storage box from the movable member, and then the clip storage box can be cleaned.

Abstract: Provided are a clip assembly and a refrigerating and freezing device provided with same, wherein the clip assembly comprises a fixed member used for fixing to the refrigerating and freezing device, clips, a clip storage box, and a movable member. The clip storage box has a storage cavity used for storing the clips. The clips may be stored and organized, and are convenient for users to access. Moreover, the movable member has an accommodating space that accommodates the clip storage box. The clip storage box is detachably accommodated in the accommodating space, and the movable member is configured to operably rotate to the side away from the fixed member, which facilitates the removal of the clip storage box from the movable member, and then the clip storage box can be cleaned.

Abstract: A network server that includes at least a processor is configured to receive, from a first network, a trigger event received in the first network from a non web-enabled device configured to communicate the trigger event to the first network, wherein the trigger event includes a designation of at least one file to be transferred. The network server is further configured to transmit a notification that includes the designation to a second network based on the trigger event, the second network being a web-enabled network communicatively coupled to at least a first web-enabled peer node that is capable of receiving the notification.

Abstract: A system and method for managed peer-to-peer (p2p) file sharing. The peer nodes can include a web browser and a p2p agent. The web browser can connect to the Internet and can interface with the p2p agent. The p2p agent provides the file sharing utilities for implementing the p2p network. A web server connected to the Internet can monitor and manage p2p activity, including providing persistent storage for the p2p networks. The web server can interface with a Public Switched Telephone Network (PSTN) to provide access to the p2p network for PSTN peer nodes that do not have web browsing capabilities. A method of implementing managed p2p file sharing includes registering users; providing login and logout functions; creating p2p sessions; preparing, forwarding, receiving, accepting and/or rejecting invitations to join p2p sessions; quitting p2p sessions; deleting p2p sessions or selected members of p2p sessions; and sharing and transferring files.

Abstract: A system and method for managed peer-to-peer (p2p) file sharing. The peer nodes can include a web browser and a p2p agent. The web browser can connect to the Internet and can interface with the p2p agent. The p2p agent provides the file sharing utilities for implementing the p2p network. A web server connected to the Internet can monitor and manage p2p activity, including providing persistent storage for the p2p networks. The web server can interface with a Public Switched Telephone Network (PSTN) to provide access to the p2p network for PSTN peer nodes that do not have web browsing capabilities. A method of implementing managed p2p file sharing includes registering users; providing login and logout functions; creating p2p sessions; preparing, forwarding, receiving, accepting and/or rejecting invitations to join p2p sessions; quitting p2p sessions; deleting p2p sessions or selected members of p2p sessions; and sharing and transferring files.

Abstract: A system and method for managed peer-to-peer (p2p) file sharing. The peer nodes can include a web browser and a p2p agent. The web browser can connect to the Internet and can interface with the p2p agent. The p2p agent provides the file sharing utilities for implementing the p2p network. A web server connected to the Internet can monitor and manage p2p activity, including providing persistent storage for the p2p networks. The web server can interface with a Public Switched Telephone Network (PSTN) to provide access to the p2p network for PSTN peer nodes that do not have web browsing capabilities. A method of implementing managed p2p file sharing includes registering users; providing login and logout functions; creating p2p sessions; preparing, forwarding, receiving, accepting and/or rejecting invitations to join p2p sessions; quitting p2p sessions; deleting p2p sessions or selected members of p2p sessions; and sharing and transferring files.