Abstract: A therapeutic device, therapeutic system and therapeutic method for myocardium repair, wherein the therapeutic device comprises a treatment needle for piercing the heart to release a therapeutant. The treatment needle includes a needle body (5a), the interior of the needle body (5) has a therapeutant conveying cavity, an end of the needle body (5a) is a needle (5b) which can pierce the myocardium and guide the needle body (5a) to pass through the myocardium, and the needle (5b) has a therapeutant output port which is connected to the therapeutant conveying cavity. The therapeutic device enters into the myocardium in a minimally invasive manner to release the therapeutant to the vicinity of the lesion to improve myocardial function or activity and prevent further deterioration of the disease.

Abstract: The present invention belongs to the field of medicinal chemistry and relates to a class of substituted tricyclic compounds as PRMT5 inhibitors and the use thereof. Specifically, the present invention provides a compound represented by formula (A) or an isomer, pharmaceutically acceptable salt, solvate, crystal or prodrug thereof, a preparation method therefor, a pharmaceutical composition containing the compounds, and the use of the compounds or the composition for treating a disease mediated by PRMT5. The compounds of the present invention show significant inhibitory activity on PRMT5.

Abstract: A device configured to collect to-be-verified identity information of a user and a device configured to verify the to-be-verified identity information may perform a user identity verification method. The device configured to collect the to-be-verified identity information or the device configured to verify the to-be-verified identity information may determine a target identity verification manner applicable to a non-self device from a plurality of identity verification manners based on device information of the non-self device.

Abstract: A method to create and run a program in a computer including includes: connecting a preset USB-HID device to a computer, wherein the USB-HID device is provided with a first storage area, stores working codes in the first storage area in binary form; the USB-HID device injects a control instruction to the computer, such that the computer creates a text document or opens a command line program according to the control instruction; if the computer creates a text document, the USB-HID device inputs the working codes in the form of keyboard sequence to generate an application corresponding to the working codes, and controls the computer to run the application; and if the computer opens a command line program, the USB-HID device inputs the working codes in the form of keyboard sequence, such that the computer directly runs the working codes through the command line program.