Patents by Inventor Lixiang XUE

Lixiang XUE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240398789
    Abstract: The present invention belongs to the field of medicine. Provided is a pharmaceutical composition for enhancing the anti-tumor effect of an EZH2 inhibitor. The pharmaceutical composition comprises an EZH2 inhibitor and a PPAR?agonist, wherein the PPAR? agonist enhances the anti-solid tumor effect of the EZH2 inhibitor. Further provided in the present invention are a related preparation of the pharmaceutical composition and the use thereof in the preparation of an anti-tumor drug. Experimental results show that when the EZH2 inhibitor GSK126 and the PPAR? agonist fenofibrate are used in combination to treat B16F10 cells, SMMC7721 cells and GL261 cells, it is found that the use thereof in combination with fenofibrate can significantly enhance the inhibitory effect of GSK126 on cell proliferation.
    Type: Application
    Filed: October 13, 2022
    Publication date: December 5, 2024
    Applicant: PEKING UNIVERSITY THIRD HOSPITAL
    Inventors: Lixiang XUE, Yan WANG, Tengrui ZHANG, Zhengyang GUO, Yueqing GONG, Qianqian YIN, Yan SUN, Hui MENG, Xiaojuan MA
  • Publication number: 20240325385
    Abstract: Provided is a pharmaceutical composition for enhancing the anti-tumor effect of an EZH2 inhibitor. The pharmaceutical composition includes an EZH2 inhibitor and an SCD1 inhibitor. The SCD1 inhibitor enhances the effect of the EZH2 inhibitor on a solid tumor. Further provided are a related preparation of the pharmaceutical composition and the use thereof in the preparation of an anti-tumor drug.
    Type: Application
    Filed: June 14, 2024
    Publication date: October 3, 2024
    Applicant: PEKING UNIVERSITY THIRD HOSPITAL
    Inventors: Lixiang XUE, Zhengyang GUO, Tengrui ZHANG, Yan WANG, Yan SUN, Yueqing GONG