Patents by Inventor Lixuan Lisa Huang

Lixuan Lisa Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Host cells and methods for production of isobutanol
    Patent number: 9790521
    Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: October 17, 2017
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Larry Cameron Anthony, Hongxian He, Lixuan Lisa Huang, Daniel P. Okeefe, Arthur Leo Kruckeberg, Yougen Li, Lori Ann Maggio-Hall, Jessica McElvain, Mark J. Nelson, Ranjan Patnaik, Steven Cary Rothman
  • Host Cells and Methods for Production of Isobutanol
    Publication number: 20170275652
    Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.
    Type: Application
    Filed: April 3, 2017
    Publication date: September 28, 2017
    Inventors: Larry Cameron Anthony, Hongxian HE, Lixuan Lisa HUANG, Daniel P. O'KEEFE, Arthur Leo KRUCKBERG, Yougen LI, Lori Ann MAGGIO-HALL, Jessica MCELVAIN, Mark J. NELSON, Ranjan PATNAIK, Steven Cary ROTHMAN
  • Host cells and methods for production of isobutanol
    Patent number: 9422581
    Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 23, 2016
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Larry Cameron Anthony, Hongxian He, Lixuan Lisa Huang, Daniel P. Okeefe, Arthur Leo Kruckeberg, Yougen Li, Lori Ann Maggio-Hall, Jessica McElvain, Mark J. Nelson, Ranjan Patnaik, Steven Cary Rothman
  • Host cells and methods for production of isobutanol
    Patent number: 9422582
    Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 23, 2016
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Larry Cameron Anthony, Hongxian He, Lixuan Lisa Huang, Daniel P. Okeefe, Arthur Leo Kruckeberg, Yougen Li, Lori Ann Maggio-Hall, Jessica McElvain, Mark J. Nelson, Ranjan Patnaik, Steven Cary Rothman
  • Fermentive production of four carbon alcohols
    Patent number: 9297028
    Abstract: Methods for the fermentive production of four carbon alcohols is provided. Specifically, butanol, preferably 1-butanol is produced by the fermentive growth of a recombinant bacterium expressing a 1-butanol biosynthetic pathway.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: March 29, 2016
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Gail K. Donaldson, Lixuan Lisa Huang, Lori Ann Maggio-Hall, Vasantha Nagarajan, Charles E. Nakamura, Wonchul Suh
  • FERMENTATIVE PRODUCTION OF ALCOHOLS
    Publication number: 20150218595
    Abstract: The invention relates to the development of microorganisms capable of producing fermentation products via an engineered pathway in the microorganisms. The invention also relates to microorganisms with improved cell viability and methods to improve cell viability and cell productivity of a microorganism.
    Type: Application
    Filed: August 22, 2013
    Publication date: August 6, 2015
    Applicant: Butamax Advanced Biofuels LLC
    Inventors: Bhaskar Bhadra, Lixuan Lisa Huang
  • Production of isobutanol in yeast mitochondria
    Patent number: 8828694
    Abstract: Yeast cells with modified expression of certain enzyme activities in the mitochondria are described for isobutanol production. Modifications described provide an isobutanol biosynthesis pathway in the yeast mitochondria.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: September 9, 2014
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Larry Cameron Anthony, Lixuan Lisa Huang, Rick W. Ye
  • Immobilized TAL biocatalyst for production of para-hydroxycinnamic acid
    Patent number: 8569036
    Abstract: TAL cell biocatalyst was immobilized in alginate cross-linked beads using low concentrations of glutaraldehyde. The biocatalyst beads have highly stable TAL activity and mechanical strength such that they withstand prolonged recycling in production of pHCA.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: October 29, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: Robert Dicosimo, Sharon L. Haynie, Lixuan Lisa Huang, Fateme Sima Sariaslani, Tina K. Van Dyk, Robert J. Trotman
  • HOST CELLS AND METHODS FOR PRODUCTION OF ISOBUTANOL
    Publication number: 20130071898
    Abstract: Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.
    Type: Application
    Filed: March 23, 2012
    Publication date: March 21, 2013
    Applicant: Butamax(TM) Advanced Biofuels LLC
    Inventors: LARRY CAMERON ANTHONY, Hongxian He, Lixuan Lisa Huang, Daniel P. Okeefe, Arthur Leo Kruckeberg, Yougen Li, Lori Ann Maggio-Hall, Jessica Mcelvain, Mark J. Nelson, Ranjan Patnaik, Steven Cary Rothman
  • FERMENTIVE PRODUCTION OF FOUR CARBON ALCOHOLS
    Publication number: 20120196341
    Abstract: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein.
    Type: Application
    Filed: October 26, 2011
    Publication date: August 2, 2012
    Applicant: BUTAMAX(TM) ADVANCED BIOFUELS LLC
    Inventors: Gail K. Donaldson, Andrew C. Eliot, Vasantha Nagarajan, Charles E. Nakamura, Lixuan Lisa Huang
  • Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
    Patent number: 8206970
    Abstract: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol biosynthetic pathways disclosed herein.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: June 26, 2012
    Assignee: Butamax(TM) Advanced Biofuels LLC
    Inventors: Andrew C. Eliot, Vasantha Nagarajan, Lixuan Lisa Huang
  • Method for the production of resveratrol in a recombinant oleaginous microorganism
    Patent number: 7772444
    Abstract: Methods to produce resveratrol and/or resveratrol glucoside in a recombinant oleaginous microorganism are provided. Expression of a resveratrol synthase gene in combination with genes involved in the phenylpropanoid pathway enabled recombinant microbial production of resveratrol in significant amounts.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: August 10, 2010
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Lixuan Lisa Huang, Zhixiong Xue, Quinn Qun Zhu
  • PRODUCTION OF ISOBUTANOL IN YEAST MITOCHONDRIA
    Publication number: 20100129886
    Abstract: Yeast cells with modified expression of certain enzyme activities in the mitochondria are described for isobutanol production. Modifications described provide an isobutanol biosynthesis pathway in the yeast mitochondria.
    Type: Application
    Filed: November 12, 2009
    Publication date: May 27, 2010
    Applicant: BUTAMAX (TM) ADVANCED BIOFUELS LLC
    Inventors: Larry Cameron Anthony, Lixuan Lisa Huang, Rick W. Ye
  • Method of production of para-hydroxycinnamic acid using a thermostable TAL enzyme
    Patent number: 7572612
    Abstract: A thermostable TAL enzyme was identified from the fungus Phanerochaete chrysosporium, which has high activity at temperatures of 40° C. to about 60° C. The enzyme was produced in engineered cells and used for production of para-hydroxycinnamic acid (pHCA) from tyrosine. When the pHCA production reaction was run at high temperature, the enzyme was more active and pHCA was produced more rapidly, making the reaction more efficient.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: August 11, 2009
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Lixuan Lisa Huang, Zhixiong Xue, Michael P. McCluskey
  • Method for the production of resveratrol in a recombinant oleaginous microorganism
    Publication number: 20090082286
    Abstract: Methods to produce resveratrol and/or resveratrol glucoside in a recombinant oleaginous microorganism are provided. Expression of a resveratrol synthase gene in combination with genes involved in the phenylpropanoid pathway enabled recombinant microbial production of resveratrol in significant amounts.
    Type: Application
    Filed: May 17, 2006
    Publication date: March 26, 2009
    Inventors: Lixuan Lisa Huang, Zhixiong Xue, Quinn Qun Zhu
  • Method of production of para-hydroxycinnamic acid using a thermostable TAL enzyme
    Publication number: 20080213846
    Abstract: A thermostable TAL enzyme was identified from the fungus Phanerochaete chrysosporium, which has high activity at temperatures of 40° C. to about 60° C. The enzyme was produced in engineered cells and used for production of para-hydroxycinnamic acid (pHCA) from tyrosine. When the pHCA production reaction was run at high temperature, the enzyme was more active and pHCA was produced more rapidly, making the reaction more efficient.
    Type: Application
    Filed: July 12, 2006
    Publication date: September 4, 2008
    Inventors: Lixuan Lisa Huang, Michael P. McCluskey, Zhixiong Xue
  • Fermentive production of four carbon alcohols
    Publication number: 20080182308
    Abstract: Methods for the fermentive production of four carbon alcohols is provided. Specifically, butanol, preferably 1-butanol is produced by the fermentive growth of a recombinant bacterium expressing a 1-butanol biosynthetic pathway.
    Type: Application
    Filed: September 27, 2006
    Publication date: July 31, 2008
    Inventors: Gail K. Donaldson, Lixuan Lisa Huang, Lori Ann Maggio-Hall, Vasantha Nagarajan, Charles E. Nakamura, Wonchul Suh
  • Immobilized TAL biocatalyst for production of para-hydroxycinnamic acid
    Publication number: 20080032371
    Abstract: TAL cell biocatalyst was immobilized in alginate cross-linked beads using low concentrations of glutaraldehyde. The biocatalyst beads have highly stable TAL activity and mechanical strength such that they withstand prolonged recycling in production of pHCA.
    Type: Application
    Filed: July 12, 2006
    Publication date: February 7, 2008
    Inventors: Robert Dicosimo, Sharon L. Haynie, Lixuan Lisa Huang, Fateme Sima Sariaslani, Robert J. Trotman, Tina K. Van Dyk
  • Method of production of para-hydroxycinnamic acid
    Publication number: 20080014619
    Abstract: Methods for the production of PHCA are disclosed. The methods rely on the tight gene expression of genetic constructs encoding polypeptides having tyrosine ammonia lyase activity. Promoters of choice are arabinose inducible.
    Type: Application
    Filed: July 12, 2006
    Publication date: January 17, 2008
    Inventors: Lixuan Lisa Huang, Tina K. Van Dyk