Patents by Inventor Liyan He

Liyan He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10981813
    Abstract: A method for eliminating harmful algal blooms through optimized utilization of a modified clay method includes building a real-time state index and a standardized value grading system for eliminating a site harmful algal bloom or a harmful algal bloom in accordance with the features of monitored harmful algal bloom organisms and modified clay flocculates; acquiring corresponding grade codes of feature index values of the harmful algal bloom in a to-be-treated water body or harmful algal bloom elimination effect through the real-time site state index and the standardized value grading system; comparing the above grade codes with an expert system to obtain an operation solution for eliminating harmful algal blooms through optimized utilization of the modified clay method. The result is tracked and monitored in real time and the operation solution is optimized and adjusted in time according to the harmful algal bloom elimination effect.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: April 20, 2021
    Assignee: INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Xihua Cao, Zhiming Yu, Xiuxian Song, Yongquan Yuan, Zaixing Wu, Liyan He
  • Patent number: 10822258
    Abstract: A device for treating harmful algal blooms using modified clay includes a power system, a screw conveying storage bin storing and conveying modified clay to a mixed flow system, the mixed flow system that continuously disperses the modified clay in water which is pumped in in site and endowed an impulse so that an adjustable turbulence is formed to instantly adopt the fed powder and then make sure the slurry uniform and ripened, a high-pressure sprinkling system for pressurizing a ripened modified clay slurry and sprinkling the slurry onto the surface of the bloomed water, and a central control system that controls the whole auxiliary device.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: November 3, 2020
    Assignee: INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Xihua Cao, Zhiming Yu, Xiuxian Song, Yongquan Yuan, Zaixing Wu, Liyan He
  • Publication number: 20190039923
    Abstract: A device for treating harmful algal blooms using modified clay includes a power system, a screw conveying storage bin storing and conveying modified clay to a mixed flow system, the mixed flow system that continuously disperses the modified clay in water which is pumped in in site and endowed an impulse so that an adjustable turbulence is formed to instantly adopt the fed powder and then make sure the slurry uniform and ripened, a high-pressure sprinkling system for pressurizing a ripened modified clay slurry and sprinkling the slurry onto the surface of the bloomed water, and a central control system that controls the whole auxiliary device.
    Type: Application
    Filed: May 11, 2017
    Publication date: February 7, 2019
    Inventors: Xihua CAO, Zhiming YU, Xiuxian SONG, Yongquan YUAN, Zaixing WU, Liyan HE
  • Publication number: 20180362375
    Abstract: A method for eliminating harmful algal blooms through optimized utilization of a modified clay method includes building a real-time state index and a standardized value grading system for eliminating a site harmful algal bloom or a harmful algal bloom in accordance with the features of monitored harmful algal bloom organisms and modified clay flocculates; acquiring corresponding grade codes of feature index values of the harmful algal bloom in a to-be-treated water body or harmful algal bloom elimination effect through the real-time site state index and the standardized value grading system; comparing the above grade codes with an expert system to obtain an operation solution for eliminating harmful algal blooms through optimized utilization of the modified clay method. The result is tracked and monitored in real time and the operation solution is optimized and adjusted in time according to the harmful algal bloom elimination effect.
    Type: Application
    Filed: August 22, 2018
    Publication date: December 20, 2018
    Inventors: Xihua CAO, Zhiming YU, Xiuxian SONG, Yongquan YUAN, Zaixing WU, Liyan HE
  • Publication number: 20150005194
    Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
    Type: Application
    Filed: May 9, 2014
    Publication date: January 1, 2015
    Applicant: Sequenom, Inc.
    Inventors: Andreas BRAUN, Hubert Köster, Dirk Van Den Boom, Ping Yip, Charlie Rodi, Liyan He, Norman Chiu, Christian Jurinke
  • Patent number: 8818735
    Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: August 26, 2014
    Assignee: Sequenom, Inc.
    Inventors: Andreas Braun, Hubert Köster, Dirk Johannes Van Den Boom, Ping Yip, Charles Rodi, Liyan He, Norman Chiu, Christian Jurinke
  • Publication number: 20120301882
    Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
    Type: Application
    Filed: June 28, 2012
    Publication date: November 29, 2012
    Applicant: SEQUENOM, INC.
    Inventors: Hubert Köster, Andreas BRAUN, Dirk Van Den Boom, Yip Ping, Charlie Rodi, Liyan He, Norman Chiu, Christian Jurinke
  • Patent number: 8229677
    Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: July 24, 2012
    Assignee: Sequenom, Inc.
    Inventors: Andreas Braun, Hubert Koster, Dirk Van den Boom, Ping Yip, Charles Rodi, Liyan He, Norman Chiu, Christiane Jurinke
  • Publication number: 20100292930
    Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
    Type: Application
    Filed: December 21, 2009
    Publication date: November 18, 2010
    Applicant: SEQUENOM, INC.
    Inventors: Hubert Köster, Andreas Braun, Dirk Van Den Boom, Yip Ping, Charlie Rodi, Liyan He, Norman Chiu, Christian Jurinke
  • Patent number: 7668658
    Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: February 23, 2010
    Assignee: Sequenom, Inc.
    Inventors: Hubert Köster, Andreas Braun, Dirk Van Den Boom, Yip Ping, Charlie Rodi, Liyan He, Norman Chiu, Christian Jurinke
  • Publication number: 20080138801
    Abstract: The present invention provides methods for detecting nucleic acids by generating mass changes in a ligand on an SPR surface through target-dependent enzymatic reaction.
    Type: Application
    Filed: May 27, 2005
    Publication date: June 12, 2008
    Inventor: Liyan He
  • Patent number: 6949632
    Abstract: The subject invention provides compounds useful as fluorogenic substrates for the hydrolytic enzymes. Upon hydrolysis of the hydrolyzable group, a halo-pyrene substituted molecule is developed which is highly fluorescent, water soluble and exhibits several desirable characteristics, including a large Stokes' shift.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: September 27, 2005
    Assignee: Chromagen, Inc.
    Inventors: Michael J. Conrad, Liyan He
  • Publication number: 20040224330
    Abstract: The present invention describes methods to construct circularization indexers and use them to selectively circularize, purify, and manipulate nucleic acids from a complex nucleic acid mixture. An assay is provided to detect nucleic acid without any amplification. Kits for preparing indexing nucleic acid targets and for high-level multiplexing DNA amplification are provided. The present invention also describes a method to construct a nucleic acids amplification assembly, in which the nucleic acid amplification is self-primed without the need for external primers. In this method, double stranded oligonucleotides with two cohesive ends (C-indexers) are used to circularize double-stranded or single-stranded nucleic acid targets in such a way that one of the strands is completely circularized while the other strand either contains a nick (if the targets are double-stranded) or is only hybridized to part of the targets (if the targets are single-stranded).
    Type: Application
    Filed: January 15, 2004
    Publication date: November 11, 2004
    Inventor: Liyan He
  • Publication number: 20030207297
    Abstract: A method for discovery of a polymorphism in a population is provided. The method includes the steps of obtaining samples of body tissue or fluid from a plurality of organisms; isolating a biopolymer from each sample; pooling each isolated biopolymer; optionally amplifying the amount of biopolymer; cleaving the pooled biopolymers to produce fragments thereof; obtaining a mass spectrum of the resulting fragments; and comparing the frequency of each fragment to identify fragments present in amounts lower than the average frequency, thereby identifying any polymorphisms.
    Type: Application
    Filed: October 15, 2002
    Publication date: November 6, 2003
    Inventors: Hubert Koster, Andreas Braun, Dirk Van Den Boom, Ping Yip, Charlie Rodi, Liyan He, Norman Chiu, Christian Jurinke
  • Patent number: 6635435
    Abstract: The subject invention provides compounds useful as fluorogenic substrates. Upon hydrolysis of a hydrolyzable group, a halo-pyrene substituted molecule is developed which is highly fluorescent, water soluble and exhibits several desirable characteristics, including a large Stokers' shift.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: October 21, 2003
    Assignee: Chromagen, Inc.
    Inventors: Michael J. Conrad, Liyan He
  • Publication number: 20030180749
    Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.
    Type: Application
    Filed: October 15, 2002
    Publication date: September 25, 2003
    Inventors: Hubert Koster, Andreas Braun, Dirk Van Den Boom, Ping Yip, Charlie Rodi, Liyan He, Norman Chiu, Christian Jurinke
  • Publication number: 20030049714
    Abstract: The subject invention provides compounds useful as fluorogenic substrates for the hydrolytic enzymes. Upon hydrolysis of the hydrolyzable group, a halo-pyrene substituted molecule is developed which is highly fluorescent, water soluble and exhibits several desirable characteristics, including a large Stokes' shift.
    Type: Application
    Filed: August 27, 2002
    Publication date: March 13, 2003
    Inventors: Michael J. Conrad, Liyan He