Abstract: To solve the problem that an excellent carrier material is absent in a storage and use process of the bone morphogenetic protein, based on self-polymerization universality of dopamine, the positively-charged polyelectrolyte, the negatively-charged polyelectrolyte and the ceramic powder with biological activity are integrated onto the titanium base material in a layer-by-layer assembly mode to construct a bone morphogenetic protein slow-release system, so that long-acting slow release, on a lesion part, of the bone morphogenetic protein is achieved. The slow-release system has the advantages of being high in surface modulus, stable, resistant to radiation, good in biocompatibility, and the like, can effectively promote osteogenic differentiation of the mesenchymal stem cells, and can be expected to effectively promote bone repair.