Patents by Inventor Liyan YUE

Liyan YUE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of aminomethylenecyclohexane-1,3-dione compound
    Patent number: 11529321
    Abstract: The present invention relates to use of an aminomethylenecyclohexane-1,3-dione compound, more particularly to use of a compound shown in the following formula (I) or a pharmaceutically acceptable salt thereof alone or in combination with other drug in preparing a drug for regulating or treating a disease related to autophagy, especially mammalian ATG8 homologous proteins.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: December 20, 2022
    Assignee: WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.
    Inventors: Cheng Luo, Liyan Yue, Wei Wan, Yuanyuan Zhang, Hualiang Jiang, Kaixian Chen
  • Compound used as autophagy regulator, and preparation method therefor and uses thereof
    Patent number: 11319303
    Abstract: It is related to compounds used as autophagy modulators and a method for preparing and using the same, specifically providing a compound of general formula (I), or pharmaceutically acceptable salts thereof, which is a type of autophagy modulators, particularly mammalian ATG8 homologues modulators.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: May 3, 2022
    Assignee: WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.
    Inventors: Cheng Luo, Yuli Xie, Bing Zhou, Zhiyi Yao, Liyan Yue, Wei Wan, Bidong Zhang, Yuanyuan Zhang, Hualiang Jiang, Kaixian Chen
  • Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof
    Patent number: 11021457
    Abstract: The present invention provides an isoindolone-imide ring-1,3-dione-2-ene compound, and a preparation method, a pharmaceutical composition and use thereof. Specifically, the present invention provides a compound of Formula (I) below or a pharmaceutically acceptable salt thereof, wherein Ar is an isoindolinone-imide group represented by Formula (II), L is absent or is a divalent, trivalent or tetravalent linking group, and X is a group represented by Formula (III). Definitions of the other groups are as described in the specification. The compound of Formula (I) is an autophagy modulators, particularly a mammalian ATG8 homolog modulator.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: June 1, 2021
    Assignee: WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.
    Inventors: Zhiyi Yao, Cheng Luo, Yuli Xie, Liyan Yue, Wei Wan, Yuanyuan Zhang, Hualiang Jiang, Kaixian Chen
  • COMPOUND USED AS AUTOPHAGY REGULATOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF
    Publication number: 20200190066
    Abstract: It is related to compounds used as autophagy modulators and a method for preparing and using the same, specifically providing a compound of general formula (I), or pharmaceutically acceptable salts thereof, which is a type of autophagy modulators, particularly mammalian ATG8 homologues modulators.
    Type: Application
    Filed: May 18, 2018
    Publication date: June 18, 2020
    Inventors: Cheng LUO, Yuli XIE, Bing ZHOU, Zhiyi YAO, Liyan YUE, Wei WAN, Bidong ZHANG, Yuanyuan ZHANG, Hualiang JIANG, Kaixian CHEN
  • USE OF AMINOMETHYLENECYCLOHEXANE-1,3-DIONE COMPOUND
    Publication number: 20200170966
    Abstract: The present invention relates to use of an aminomethylenecyclohexane-1,3-dione compound, more particularly to use of a compound shown in the following formula (I) or a pharmaceutically acceptable salt thereof alone or in combination with other drug in preparing a drug for regulating or treating a disease related to autophagy, especially mammalian ATG8 homologous proteins.
    Type: Application
    Filed: May 18, 2018
    Publication date: June 4, 2020
    Inventors: Cheng LUO, Liyan YUE, Wei WAN, Yuanyuan ZHANG, Hualiang JIANG, Kaixian CHEN
  • METHOD FOR COVALENT BOND MODIFYING MAMMALIAN ATG8 HOMOLOGUE
    Publication number: 20200069609
    Abstract: The present invention provides a method (I) for modifying a mammalian ATG8 homologue by a covalent bond, comprising: providing a compound SM-LG including a moiety SM- having a function of modulating a mammalian ATG8 homologue and a leaving moiety -LG; the compound SM-LG reacts with a mammalian ATG8 homologue to produce a covalent complex of the mammalian ATG8 homologue. The invention also provides a covalent complex of the mammalian ATG8 homologue obtained by the method and uses of the same.
    Type: Application
    Filed: May 18, 2018
    Publication date: March 5, 2020
    Inventors: Cheng LUO, Zhiyi YAO, Yuli XIE, Wei WAN, Liyan YUE, Yuanyuan ZHANG, Hualiang JIANG, Kaixian CHEN
  • A CLASS OF ISOINDOLONE-IMIDE RING-1,3-DIONE-2-ENE COMPOUNDS, COMPOSITION AND USE THEREOF
    Publication number: 20200071291
    Abstract: The present invention provides an isoindolone-imide ring-1,3-dione-2-ene compound, and a preparation method, a pharmaceutical composition and use thereof. Specifically, the present invention provides a compound of Formula (I) below or a pharmaceutically acceptable salt thereof, wherein Ar is an isoindolinone-imide group represented by Formula (II), L is absent or is a divalent, trivalent or tetravalent linking group, and X is a group represented by Formula (III). Definitions of the other groups are as described in the specification. The compound of Formula (I) is an autophagy modulators, particularly a mammalian ATG8 homolog modulator.
    Type: Application
    Filed: May 17, 2018
    Publication date: March 5, 2020
    Inventors: Zhiyi YAO, Cheng LUO, Yuli XIE, Liyan YUE, Wei WAN, Yuanyuan ZHANG, Hualiang JIANG, Kaixian CHEN