Abstract: The present disclosure discloses a key amino acid-induced new crystal forms of trelagliptin based on protein-drug interaction structure mining and preparation method thereof; the technical solution is to introduce key amino acids into the solvent crystallization system of trelagliptin to induce five new crystal forms of trelagliptin; the preparation method does not require the use of a large amount of organic solvent, and has the characteristics of simplicity, precision and high efficiency, with a strong ability of crystal form regulation, and energy saving, environmental protection, safety, and easy to realize green industrial production.

Abstract: A suppository for treating human ailments comprising at least one herb and a suppository vehicle. A method of treating undesired symptoms from allergic rhinitis, sinusitis, nasal congestion, nasal dripping, nasal polyps, infections, fevers, coughs, spasms, dizziness, convulsions in a human uses a suppository having herbs. Methods of producing, administrating and formulating herbal medicines in the form of suppositories to treat human aliments and disease are disclosed in this invention.