Abstract: The present application relates to a pregabalin sustained release composition, comprising: (a) an active ingredient; (b) a matrix-forming agent; (c) a swelling agent; (d) a gelling agent; and optionally a filler. The pregabalin sustained release composition provided in the present application can rapidly swell in volume when exposed to aqueous medium until exceeding the dimeter of human gastric pyloric (13 mm). It thereby prolongs the gastric emptying time to increase the retention time of pregabalin in the stomach and enhances absorption of pregabalin in the small intestine and ascending colon. Moreover, the pregabalin sustained release composition provided herein achieves a sustained release for 24 h, which allows QD (once a day) administration, reduces administration number, and improves patient compliance.

Abstract: A universal serial bus (USB) cradle includes a USB connector configured to engage the USB cradle with an external device. The USB further includes a cradle base integrated with the USB connector. The cradle base includes a cavity configured to accept an audio device in a docked configuration, and a magnetic connector configured to hold the audio device in a given position and orientation when the audio device is docked with the USB cradle.

Abstract: An electronic apparatus that includes a first port configured to receive an incoming audio signal, a second port, and a controller configured to be coupled to the first port and the second port. The electronic apparatus further includes a switch configured to selectively decouple the controller from the second port when the first port receives the incoming audio signal. Decoupling the controller prevents an electrostatic discharge occurring on the second port from reaching the controller when the controller is receiving the incoming audio signal from the first port.

Abstract: An earpiece including an earbud. The earbud includes a stem having a proximal end and a distal end, a speaker disposed inside the stem at the distal end, and a sleeve disposed inside the stem. The earpiece also includes a housing connected to the proximal end of the stem. The housing contains firmware configured to communicate electronically with the speaker and to communicate wirelessly with an external device. The housing also contains curved partial sleeves. Each of the curved partial sleeves is adjacent an inner surface of a wall of the housing.

Abstract: An earpiece including an earbud. The earbud includes a stem having a proximal end and a distal end, a speaker disposed inside the stem at the distal end, and a sleeve disposed inside the stem. The earpiece also includes a housing connected to the proximal end of the stem. The housing contains firmware configured to communicate electronically with the speaker and to communicate wirelessly with an external device. The housing also contains curved partial sleeves. Each of the curved partial sleeves is adjacent an inner surface of a wall of the housing.

Abstract: A method for stably transforming barley from mature barley seeds as starting material is disclosed. The method involves germinating mature barley seeds until early shoot development occurs, exposing scutellar or embryo tissue cells on the embryo side of germinated seeds, and introducing foreign DNA into the cells. The cells are initially grown under conditions that allow expression of a selectable marker introduced with the foreign DNA, then on a callus-growth medium effective to suppress callus formation in the absence of the selectable marker. Successfully transformed calli can be cultured in suspension to obtain a desired foreign protein, or regenerated into plants, to obtain the foreign protein from the transformed plants, e.g., germinated seeds.