Patents by Inventor Liying Zhang
Liying Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220144681Abstract: Methods for manufacturing glass articles having a target effective coefficient of thermal expansion CTETeff averaged over a temperature range comprise selecting a glass core composition having an average core glass coefficient of thermal expansion CTEcore that is greater than the target effective CTETeff and a glass clad composition having an average clad glass coefficient of thermal expansion CTEclad that is less than the target effective CTETeff; and manufacturing a glass laminate comprising a glass core layer formed from the glass core composition and two or more glass cladding layers fused to the glass core layer, each of the two or more glass cladding layers formed from the glass clad composition such that a ratio of a thickness of the glass core layer to a total thickness of the two or more glass cladding layers is selected to produce the glass laminate having an effective coefficient of thermal expansion CTEeff that is within ±0.5 ppm/° C. of the target effective CTETeff.Type: ApplicationFiled: February 24, 2020Publication date: May 12, 2022Inventors: Heather Debra Boek, Timothy Michael Gross, Jin Su Kim, Jesse Kohl, Hung Cheng Lu, Yu Xiao, Liying Zhang, Lu Zhang
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Patent number: 11275036Abstract: A non-destructive testing method of analyzing a sample comprising a composite material is disclosed. The method comprises: emitting an electromagnetic signal onto the sample, the electromagnetic signal having a range of frequencies; detecting a response signal transmitted and/or reflected by the sample in response to the electromagnetic signal; processing the response signal to determine variation with frequency of a dielectric permittivity of the sample over the range of frequencies; and determining an indication of a structural characteristic of the sample from a measure of the variation with frequency of the dielectric permittivity of the sample.Type: GrantFiled: December 11, 2017Date of Patent: March 15, 2022Assignee: Nanyang Technological UniversityInventors: Xiao Hu, Chenzhong Mu, Liying Zhang
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Publication number: 20220043041Abstract: A stability measuring method for a synchronous generator includes: S11: collecting electrical quantities, and setting an alarm PQ curve of the synchronous generator; S12: calculating a dynamic reactive power reserve, an inductive dynamic reactive power reserve and a capacitive dynamic reactive power reserve of the synchronous generator; S13: calculating a dynamic reactive power reserve target value, an inductive dynamic reactive power reserve target value and a capacitive dynamic reactive power reserve target value of the synchronous generator; and S14: calculating a capacitive stability, an inductive stability and a stability of the synchronous generator.Type: ApplicationFiled: October 14, 2021Publication date: February 10, 2022Inventors: Chen GUO, Zhaolei WANG, Chong JIAO, Xiaoyu WANG, Xin LIU, Liying ZHANG, Anmin CAI
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Patent number: 11203594Abstract: This invention relates to compounds of general Formula I in which A, R1, R2, R3 and R4 are as defined herein, and the pharmaceutically acceptable salts thereof; to pharmaceutical compositions comprising such compounds and salts; to methods of using such compounds, salts and compositions for treating pulmonary hypertension and related diseases, like pulmonary arterial hypertension; to methods of using such compounds, salts and compositions for treating abnormal cell growth, such as cancer; and to processes to make such compounds, salts and compositions.Type: GrantFiled: April 15, 2020Date of Patent: December 21, 2021Assignee: Pfizer Inc.Inventors: Samit Kumar Bhattacharya, Douglas Carl Behenna, Kimberly O. Cameron, Ping Chen, John M. Curto, Kevin Daniel Freeman-Cook, Mehran Jalaie, Robert Steven Kania, Yajing Lian, Sajiv Krishnan Nair, Cynthia Louise Palmer, Martin Youngjin Pettersson, Eugene Yuanjin Rui, Matthew Sammons, Qingyi Yang, Liying Zhang
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Patent number: 11197867Abstract: A compound compound having the structure: or a pharmaceutically acceptable salt thereof, wherein X is N or CR, where R is hydrogen, deuterium, C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, aryl, heteroaryl, aryl(C1-C6 alkyl), CN, amino, alkylamino, dialkylamino, CF3, or hydroxyl; A is selected from the group consisting of a bond, C?O, —SO2—, —(C?O)NR0—, and —(CRaRb)q—, where R0 is H or C1-C4 alkyl, and Ra and Rb are independently hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, aryl(C1-C6 alkyl), heteroaryl, (C1-C6 alkyl)heteroaryl, etc.Type: GrantFiled: July 2, 2020Date of Patent: December 14, 2021Assignee: Pfizer Inc.Inventors: Andrew Fensome, Ariamala Gopalsamy, Brian S. Gerstenberger, Ivan Viktorovich Efremov, Zhao-Kui Wan, Betsy Pierce, Jean-Baptiste Telliez, John I. Trujillo, Liying Zhang, Li Xing, Eddine Saiah
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Publication number: 20210377495Abstract: Methods of treatment as Janus Kinase inhibitors containing the compound of the invention having the structure: or a pharmaceutically acceptable salt thereof, wherein X is N; A is selected from the group consisting of a bond and C?O; R1 is C3-C6 cycloalkyl, wherein said cycloalkyl is further optionally substituted with one or more halo; R2 is hydrogen; R3 is hydrogen; R4 is monocyclic heteroaryl wherein said heteroaryl is optionally substituted with one or more C1-C6 alkyl; and, R5 is hydrogen; and, j is 0 or 1.Type: ApplicationFiled: August 6, 2021Publication date: December 2, 2021Applicant: Pfizer Inc.Inventors: Andrew FENSOME, Ariamala GOPALSAMY, Brian S. GERSTENBERGER, Ivan Viktorovich EFREMOV, Zhao-Kui WAN, Betsy PIERCE, Jean-Baptiste TELLIEZ, John I. TRUJILLO, Liying ZHANG, Li XING, Eddine SAIAH
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Publication number: 20210236558Abstract: The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs).Type: ApplicationFiled: January 15, 2021Publication date: August 5, 2021Applicant: Rutgers, The State University of New JerseyInventors: Yufang Shi, Guangwen Ren, Liying Zhang
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Publication number: 20210213067Abstract: The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs).Type: ApplicationFiled: January 15, 2021Publication date: July 15, 2021Applicant: Rutgers, The State University of New JerseyInventors: Yufang Shi, Guangwen Ren, Liying Zhang
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Publication number: 20210206273Abstract: A controller for vehicle air conditioner includes a base defining a mounting cavity; a knob assembly rotatably mounted to the base, wherein at least a portion of the knob assembly is located in the mounting cavity; and at least one bearing element arranged between the base and the knob assembly. Such a design reduces the friction between the base and the knob assembly and thus reduces the noise.Type: ApplicationFiled: March 22, 2021Publication date: July 8, 2021Applicant: HANGZHOU SANHUA RESEARCH INSTITUTE CO., LTD.Inventors: Jundi HU, Junjie YANG, Liying ZHANG
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Publication number: 20210179482Abstract: Ion-exchanged alkali aluminosilicate glass articles with a ratio of peak compressive stress value to Young's modulus value of 14 or more. The glass articles may include Al2O3 mol %+RO mol %?18 mol %, where RO mol %=MgO mol %+CaO mol %, and be substantially free of ZnO, SrO, BaO, B2O3, P2O5, Li2O, and K2O. The glass articles may have a peak compressive stress value in a range of 850 MPa to 1400 MPa. The glass articles are suitable for various high-strength applications, including cover glass applications that experience significant bending stresses during use, for example, cover glasses for flexible displays.Type: ApplicationFiled: December 10, 2020Publication date: June 17, 2021Inventors: PETER JOSEPH LEZZI, Liying Zhang
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Patent number: 10980815Abstract: A compound having the structure: or an acceptable salt thereof, wherein X is N or CR, where R is hydrogen, alkyl, etc.; A is selected from the group consisting of a bond, C?O, —SO2—, etc.; A? is selected from the group consisting of a bond, C?O, etc.; Z is —(CH2)h— or a bond, etc.; R1 and R1? are independently selected from the group consisting of hydrogen, alkyl, etc.; R2 is selected from hydrogen, alkyl, etc.; R3 is selected from the group consisting of hydrogen, and amino; R4 is monocyclic or bicyclic, etc.; R5 is independently selected from hydrogen, alkyl, etc.; h, j, k, m, n and q are integers as defined in the specification. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations with other therapeutic agents.Type: GrantFiled: September 24, 2019Date of Patent: April 20, 2021Assignee: Pfizer Inc.Inventors: Andrew Fensome, Ariamala Gopalsamy, Brian S. Gerstenberger, Ivan Viktorovich Efremov, Zhao-Kui Wan, Betsy Pierce, Jean-Baptiste Telliez, John I. Trujillo, Liying Zhang, Li Xing, Eddine Saiah
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Patent number: 10978510Abstract: Methods of forming a MTJ dummy fill gradient across near-active-MRAM-cell periphery and far-outside-MRAM logic regions and the resulting device are provided. Embodiments include providing an embedded MRAM layout with near-active-MRAM-cell periphery logic and far-outside-MRAM logic regions; forming a MTJ structure within the layout based on minimum space and distance rules relative to a first metal layer, a second metal layer, and/or both the first and second metal layers; forming a high-density MTJ dummy structure in the near-active-MRAM-cell periphery logic region based on second minimum space and distance rules relative to a first metal layer, a second metal layer, and/or both the first metal layer and the second metal layer; and forming a low-density MTJ dummy structure in the far-outside-MRAM logic region based on third minimum space and distance rules relative to a first metal layer, a second metal layer, and/or both the first metal layer and the second metal layer.Type: GrantFiled: June 17, 2019Date of Patent: April 13, 2021Assignee: GLOBALFOUNDRIES Singapore Pte. Ltd.Inventors: Pinghui Li, Haiqing Zhou, Liying Zhang, Wanbing Yi, Ming Zhu, Danny Pak-Chum Shum, Darin Chan
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Patent number: 10920025Abstract: A method for preparing a polyolefin resin powder has the steps of a) heat dissolving a polyolefin resin in an organic solvent having a solubility parameter less than or equal to the solubility parameter of the polyolefin resin to obtain a polyolefin resin solution; b) cooling the polyolefin resin solution to precipitate a solid, thereby obtaining a solid-liquid mixture; c) optionally adding an adjuvant to the solid-liquid mixture and mixing; and d) conducting solid-liquid separation and drying to obtain a polyolefin resin powder suitable for selective laser sintering. The difference between the solubility parameters of the organic solvent and of the polyolefin resin is within 0-20% of the solubility parameter of the polyolefin resin. The polyolefin resin powder obtained according to this method has good antioxidant property, good powder flowability, moderate size, smooth surface, suitable bulk density, and suitable dispersibility and particle size distribution.Type: GrantFiled: April 15, 2016Date of Patent: February 16, 2021Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATIONInventors: Jianye Liu, Shijun Zhang, Liqiu Chu, Liying Zhang, Hao Zou, Mu Dong, Dali Gao, Baige Chou, Jingbo Shao, Yun Lyu, Hua Yin, Qingquan Yang, Jie Li, Yiqing Bai, Yihui Xu
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Patent number: 10898523Abstract: The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs).Type: GrantFiled: August 10, 2018Date of Patent: January 26, 2021Assignee: Rutgers, The State University of New JerseyInventors: Yufang Shi, Guangwen Ren, Liying Zhang
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Publication number: 20200399173Abstract: Methods of manufacturing a glass-based article comprise: after mechanical polishing of a glass-based substrate, treating at least one surface of the glass-based substrate for protection of the at least one surface from contamination and/or for removal of contaminants from the at least one surface by a treatment other than ultrasonic cleaning; and exposing the glass-based substrate to an ion exchange treatment after the treating step to form the glass-based article. The treating step includes: exposing the at least one surface to a high pH soaking for removal of contaminants; deionizing the at least one surface for removal of contaminants; and/or applying a temporary coating to the at least one surface for protection of the at least one surface from contamination, and removing the temporary coating prior to the ion exchange treatment step. The ion exchange treatment may comprise a molten salt bath having an increased pH and temperature.Type: ApplicationFiled: March 8, 2019Publication date: December 24, 2020Inventors: Jaymin Amin, Matthew John Dejneka, Yuhui Jin, Robert George Manley, Jonathan Michael Mis, Pascale Oram, Vitor Marino Schneider, Charlene Marie Smith, Wei Sun, Wanda Janina Walczak, Liying Zhang
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Publication number: 20200354262Abstract: Disclosed herein are glass compositions with high silica content that present several advantages over glasses and other materials currently used for redistribution layers for RF, interposers, and similar applications. The glasses disclosed herein are low cost, flat glasses that have high throughput for the laser damage and etching process used to create through glass vias (TGVs). TGVs generated using the silicate glasses and processes described herein have large waist diameters, which is a desirable feature with respect to producing glass articles such as interposers.Type: ApplicationFiled: April 30, 2020Publication date: November 12, 2020Inventors: Xiaoju Guo, Tian Huang, Yuhui Jin, Tammy Lynn Petriwsky, Liying Zhang
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Publication number: 20200331909Abstract: This invention relates to compounds of general Formula I in which A, R1, R2, R3 and R4 are as defined herein, and the pharmaceutically acceptable salts thereof; to pharmaceutical compositions comprising such compounds and salts; to methods of using such compounds, salts and compositions for treating pulmonary hypertension and related diseases, like pulmonary arterial hypertension; to methods of using such compounds, salts and compositions for treating abnormal cell growth, such as cancer; and to processes to make such compounds, salts and compositions.Type: ApplicationFiled: April 15, 2020Publication date: October 22, 2020Applicant: Pfizer Inc.Inventors: Samit Kumar Bhattacharya, Douglas Carl Behenna, Kimberly O. Cameron, Ping Chen, John M. Curto, Kevin Daniel Freeman-Cook, Mehran Jalaie, Robert Steven Kania, Yajing Lian, Sajiv Krishnan Nair, Cynthia Louise Palmer, Martin Youngjin Pettersson, Eugene Yuanjin Rui, Matthew Sammons, Qingyi Yang, Liying Zhang
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Publication number: 20200330477Abstract: A compound compound having the structure: or a pharmaceutically acceptable salt thereof, wherein X is N or CR, where R is hydrogen, deuterium, C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, aryl, heteroaryl, aryl(C1-C6 alkyl), CN, amino, alkylamino, dialkylamino, CF3, or hydroxyl; A is selected from the group consisting of a bond, C?O, —SO2—, —(C?O)NR0—, and —(CRaRb)q—, where R0 is H or C1-C4 alkyl, and Ra and Rb are independently hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, aryl(C1-C6 alkyl), heteroaryl, (C1-C6 alkyl)heteroaryl, etc.Type: ApplicationFiled: July 2, 2020Publication date: October 22, 2020Applicant: Pfizer Inc.Inventors: Andrew FENSOME, Ariamala GOPALSAMY, Brian S. GERSTENBERGER, Ivan Viktorovich EFREMOV, Zhao-Kui WAN, Betsy PIERCE, Jean-Baptiste TELLIEZ, John I. TRUJILLO, Liying ZHANG, Li XING, Eddine SAIAH
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Patent number: 10787546Abstract: A method for preparing an aliphatic polyester resin powder includes the steps of a) heat dissolving a crystalline aliphatic polyester resin in an organic solvent to obtain an aliphatic polyester resin solution; b) cooling the aliphatic polyester resin solution to precipitate a solid, thereby obtaining a solid-liquid mixture; c) optionally adding an adjuvant to the solid-liquid mixture and mixing; and d) conducting solid-liquid separation and drying to obtain an aliphatic polyester resin powder suitable for selective laser sintering. The crystalline aliphatic polyester resin powder obtained has good antioxidant property, good powder flowability, moderate size, smooth surface, suitable bulk density, and suitable dispersibility and particle size distribution. The aliphatic polyester resin powder is particularly suitable for selective laser sintering method.Type: GrantFiled: April 13, 2018Date of Patent: September 29, 2020Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATIONInventors: Jianye Liu, Liqiu Chu, Yun Lyu, Shijun Zhang, Liying Zhang, Hao Zou, Mu Dong, Dali Gao, Baige Chou, Yiqing Bai, Jingbo Shao, Meng Xu, Yihui Xu, Ruoshi Chen
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Publication number: 20200038409Abstract: A compound having the structure: or a pharmaceutically acceptable salt thereof, wherein X is N or CR, where R is hydrogen, deuterium, C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, aryl, heteroaryl, aryl(C1-C6 alkyl), CN, amino, alkylamino, dialkylamino, CF3, or hydroxyl; A is selected from the group consisting of a bond, C?O, —SO2—, —(C?O)NR0—, and —(CRaRb)q—, where R0 is H or C1-C4 alkyl, and Ra and Rb are independently hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, aryl(C1-C6 alkyl), heteroaryl, (C1-C6 alkyl)heteroaryl, etc.Type: ApplicationFiled: September 24, 2019Publication date: February 6, 2020Applicant: Pfizer Inc.Inventors: Andrew FENSOME, Ariamala GOPALSAMY, Brian S. GERSTENBERGER, Ivan Viktorovich EFREMOV, Zhao-Kui WAN, Betsy PIERCE, Jean-Baptiste TELLIEZ, John I. TRUJILLO, Liying ZHANG, Li XING, Eddine SAIAH