Abstract: Provided in the present invention are an anti-human CD47 antibody or an antigen-binding fragment thereof, and a preparation method therefor and the use thereof. Also provided in the present invention are an isolated polynucleotide encoding the antibody or the antigen-binding fragment thereof and a vector containing the isolated polynucleotide of the present invention. Further provided in the present invention is the use of the antibody or the antigen-binding fragment thereof according to the present invention in the preparation of a drug, the drug being used for treating and/or preventing a disease that benefits from an enhanced immune response, wherein the disease is cancer.

Abstract: The present disclosure provides a fusion protein and methods thereof for preparing a pharmaceutical composition comprising the fusion protein and for methods for treating tumors and/or viral infections using said fusion proteins and compositions, wherein the fusion protein comprises an antibody or antigen-binding fragment thereof that specifically binds to human OX40 and a human interferon.