Patents by Inventor Liz J. Hernandez Borrero

Liz J. Hernandez Borrero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE CB002-ANALOGES RESTORE THE P53 PATHWAY AND TARGET S-PHASE CHECKPOINT
    Publication number: 20230219957
    Abstract: The inventors had earlier discovered a class of anticancer xanthine-related drugs that restores p53 activity in tumors with mutated p53 and perturbs an S-phase checkpoint. Based upon the properties of this class of p53-pathway restoring drugs, the inventors developed uses in cancer treatment. The invention provides drug combinations as new therapy regimens due to synthetic lethality in cancer models.
    Type: Application
    Filed: May 17, 2021
    Publication date: July 13, 2023
    Inventors: WAFIK S. EL-DEIRY, LIZ J. HERNANDEZ BORRERO
  • Compounds For Repressing Cancer Cell Growth
    Publication number: 20220073519
    Abstract: The disclosure generally relates to compounds, compositions, and methods for the treatment of cancer by restoring the P53 pathway signaling to repress cancer cell growth.
    Type: Application
    Filed: November 16, 2021
    Publication date: March 10, 2022
    Inventors: Wafik S. El-Deiry, Shengliang Zhang, Liz J. Hernandez Borrero
  • Compounds for repressing cancer cell growth
    Patent number: 11203598
    Abstract: The disclosure generally relates to compounds, compositions, and methods for the treatment of cancer by restoring the P53 pathway signaling to repress cancer cell growth. In particular, the compounds comprise Formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen or a haloalkyl group; and each R2, R3, R4, R5, R6, and R7 is, independently, hydrogen, halogen, hydroxyl, cyano, alkyl, alkenyl, alkoxy, substituted or unsubstituted aryl, heteroaryl, phosphate, phosphoramidate, amine, alkylamino, acylamino, aminoalkoxy, or alkylthio.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: December 21, 2021
    Assignee: Institute For Cancer Research
    Inventors: Wafik S. El-Deiry, Shengliang Zhang, Liz J. Hernandez Borrero
  • Compounds For Repressing Cancer Cell Growth
    Publication number: 20190225613
    Abstract: The disclosure generally relates to compounds, compositions, and methods for the treatment of cancer by restoring the P53 pathway signaling to repress cancer cell growth.
    Type: Application
    Filed: January 23, 2019
    Publication date: July 25, 2019
    Inventors: Wafik S. El-Deiry, Shengliang Zhang, Liz J. Hernandez Borrero