Patents by Inventor Lizhe Xu

Lizhe Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION (RT-PCR) OF HUMAN B-RETROVIRUS
    Publication number: 20070237716
    Abstract: The invention can be summarized as follows. The present invention provides compositions, methods and kits useful for the amplification of nucleic acid molecules from human ?-retrovirus by reverse transcriptase-polymerase chain reaction (RT-PCR). Specifically, the invention provides compositions and methods for the amplification of nucleic acid molecules in a one or two-step real time RT-PCR procedure using reverse transcriptase, DNA polymerase, or a combination of both enzymes. The invention provides for the rapid and efficient amplification, detection and quantification of human ?-retrovirus nucleic acids.
    Type: Application
    Filed: November 30, 2006
    Publication date: October 11, 2007
    Inventors: Andrew Mason, Lizhe Xu
  • Identification of a novel retrovirus associated with primary sclerosing cholangitis and autoimmune hepatitis
    Patent number: 6787303
    Abstract: The present invention relates first, to the identification of a retrovirus and the novel nucleotide sequences encoding a retroviral polymerase gene (POL nucleotides) associated with the existence of primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH) Crohn's disease and ulcerative colitis. The present invention further relates to methods for using the PSC associated retroviral nucleotides for the detection of PSC, AIH, Crohn's disease and ulcerative colitis in patient samples. The present invention also relates to methods for using and targeting the PSC associated retroviral POL nucleotides in gene therapy protocols for the treatment of PSC, AIH, Crohn's disease or ulcerative disease in patients in need of such treatment. The present invention further relates to diagnostic protocols and kits for the detection of PSC, AIH, Crohn's disease and ulcerative colitis in tissue samples.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: September 7, 2004
    Assignee: Alton Ochsner Medical Foundation
    Inventors: Andrew L. Mason, Lizhe Xu, Linsheng Guo
  • Identification of a novel retrovirus associated with primary biliary cirrhosis and autoimmune disorders
    Patent number: 6468737
    Abstract: The present invention relates, first, to the discovery, identification, and characterization of novel nucleic acid molecules, that are associated with PBC, Sjögren's syndrome, scleroderma, SLE, autoimmune thyroiditis and various other connective tissue disorders. The novel nucleotide sequences of the present invention are retroviral in origin and are indicative of a PBC retrovirus which bears a strong correlation with PBC. The present invention is based, in part, on the Applicant's data which is the first evidence to suggest that PBC patient's tissue may harbor a transmissible agent. The association of a retroviral infectious agent with PBC was first demonstrated by Applicants in vitro by co-culture of periportal lymph nodes derived from patients at time of transplantation and healthy biliary epithelium cells.
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: October 22, 2002
    Assignee: Alton Ochsner Medical Foundation
    Inventors: Andrew L. Mason, Lizhe Xu, James Neuberger