Patents by Inventor Lizhu Niu

Lizhu Niu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pea-derived peptide with muscle-building effect and preparation method thereof, and drug and use
    Patent number: 11951155
    Abstract: A pea-derived peptide with a muscle-building effect and a preparation method thereof, and a drug and use, are disclosed. A pea protein is subjected to enzymatic hydrolysis, and five polypeptides with muscle-building effect are obtained by separation as separate peptide fragments. In an in vitro aging skeletal muscle cell assay, changes are analyzed in a gene expression level of regulatory pathways related to skeletal muscle cell proliferation and differentiation, apoptosis and autophagy, and protein synthesis and degradation. In addition, animal experiments are conducted to study the muscle-building effect and a corresponding mechanism of the pea-derived peptide. This shows that the five polypeptide sequences have a significant muscle-building effect, usable as a polypeptide drug for the treatment of sarcopenia.
    Type: Grant
    Filed: August 22, 2022
    Date of Patent: April 9, 2024
    Assignee: Zhongshi Duqing(Shandong) Biotech Co., Ltd
    Inventors: Zhao Zhang, Jiuxun Zhang, Zheng Zhang, Jie Li, Wei Wei, Xiping Zhang, Zhongli Pei, Shuai Gu, Lizhu Niu
  • PEA-DERIVED PEPTIDE WITH MUSCLE-BUILDING EFFECT AND PREPARATION METHOD THEREOF, AND DRUG AND USE
    Publication number: 20230293631
    Abstract: A pea-derived peptide with a muscle-building effect and a preparation method thereof, and a drug and use, are disclosed. A pea protein is subjected to enzymatic hydrolysis, and five polypeptides with muscle-building effect are obtained by separation as separate peptide fragments. In an in vitro aging skeletal muscle cell assay, changes are analyzed in a gene expression level of regulatory pathways related to skeletal muscle cell proliferation and differentiation, apoptosis and autophagy, and protein synthesis and degradation. In addition, animal experiments are conducted to study the muscle-building effect and a corresponding mechanism of the pea-derived peptide. This shows that the five polypeptide sequences have a significant muscle-building effect, usable as a polypeptide drug for the treatment of sarcopenia.
    Type: Application
    Filed: August 22, 2022
    Publication date: September 21, 2023
    Inventors: Zhao Zhang, Jiuxun Zhang, Zheng Zhang, Jie Li, Wei Wei, Xiping Zhang, Zhongli Pei, Shuai Gu, Lizhu Niu