Abstract: A vaccine having a fusion protein set forth as SEQ ID NO:1 containing antigenic determinants of haemagglutinins of influenza A and B viruses and flagellin fragments functioning as safe adjuvant, joined via flexible hinges is given, which can be used for prophylaxis of influenza caused by existing influenza A and B strains as well as by possible reassortants. Usage of the vaccine will provide a universal protection against influenza and provides safety, efficacy, polyvalence and preventive effect.

Abstract: The problem to be solved: absence of safe efficient universal vaccine against influenza. The solution: The vaccine based on the fusion protein consisting of antigenic determinants of haemagglutinins of influenza A and B viruses and flagellin fragments functioning as safe adjuvant (SEQ ID NO:1) joined via flexible hinges is given which can be used for prophylaxis of influenza caused by existing influenza A and B strains as well as by possible reassortants. Safety, efficacy, polyvalence and preventive effect have been demonstrated. Usage of the present vaccine will allow to provide a universal protection against influenza.