Patents by Inventor Lloyd Barnes
Lloyd Barnes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10876158Abstract: The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template.Type: GrantFiled: June 11, 2018Date of Patent: December 29, 2020Assignee: Illumina Cambridge LimitedInventors: Geoffrey Paul Smith, Jonathan Mark Boutell, Colin Lloyd Barnes, Roberto Rigatti, Niall Anthony Gormley, David Bentley, Tobias William Barr Ost, Vincent Peter Smith, Graham John Worsley, Eric Hans Vermaas
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Publication number: 20200399692Abstract: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3?-OH blocking group covalently attached thereto, such that the 3? carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R?)2-O—R?, —C(R?)2-N(R?)2, —C(R?)2-N(H)R?, —C(R?)2-S—R? and —C(R?)2-F, wherein each R? is or is part of a removable protecting group; each R? is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R?)2 represents an alkylidene group of formula ?C(R??)2 wherein each R?? may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R? is exchanged for H or, where Z is —C(R?)2-F, the F is exType: ApplicationFiled: May 18, 2020Publication date: December 24, 2020Inventors: John MILTON, Xiaolin WU, Mark Edward Brennan SMITH, Joseph BRENNAN, Colin Lloyd BARNES, Xiaohai LIU, Silke RUEDIGER
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Patent number: 10815138Abstract: Acid mine drainage is treated with borohydride under conditions to yield highly pure iron nanoparticles. The resulting, unique, iron nanoparticles are also described.Type: GrantFiled: February 7, 2019Date of Patent: October 27, 2020Assignee: GeoKinetics, LLCInventors: Hubert Lloyd Barnes, Antonio C. Lasaga
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Patent number: 10710046Abstract: The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5? end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.Type: GrantFiled: June 18, 2018Date of Patent: July 14, 2020Assignee: Illumina Cambridge LimitedInventors: Xiaohai Liu, John Milton, Geoffrey Paul Smith, Colin Lloyd Barnes, Isabelle Rasolonjatovo, Roberto Rigatti, Xiaolin Wu, Tobias William Barr Ost, Graham John Worsley, David James Earnshaw, Gerardo Turcatti, Anthony Romieu
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Publication number: 20200115747Abstract: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.Type: ApplicationFiled: December 23, 2019Publication date: April 16, 2020Inventors: Shankar BALASUBRAMANIAN, Colin Lloyd BARNES, Xiaohai LIU, Xiaolin WU, John MILTON
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Publication number: 20200109448Abstract: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.Type: ApplicationFiled: October 4, 2019Publication date: April 9, 2020Inventors: Shankar BALASUBRAMANIAN, Colin Lloyd BARNES, Xiaohai LIU, John MILTON
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Publication number: 20200017908Abstract: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3?-OH blocking group covalently attached thereto, such that the 3? carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R?)2-O—R?, —C(R?)2-N(R?)2, —C(R?)2-N(H)R?, —C(R?)2-S—R? and —C(R?)2-F, wherein each R? is or is part of a removable protecting group; each R? is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R?)2 represents an alkylidene group of formula=C(R??)2 wherein each R?? may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R? is exchanged for H or, where Z is —C(R?)2-F, the F is excType: ApplicationFiled: July 26, 2019Publication date: January 16, 2020Inventors: John MILTON, Xiaolin WU, Mark Edward Brennan SMITH, Joseph BRENNAN, Colin Lloyd BARNES, Xiaohai LIU, Silke RUEDIGER
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Patent number: 10519496Abstract: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.Type: GrantFiled: March 27, 2017Date of Patent: December 31, 2019Assignee: Illumina Cambridge LimitedInventors: Shankar Balasubramanian, Colin Lloyd Barnes, Xiaohai Liu, Xiaolin Wu, John Milton
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Patent number: 10480025Abstract: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.Type: GrantFiled: July 5, 2016Date of Patent: November 19, 2019Assignee: Illumina Cambridge LimitedInventors: Shankar Balasubramanian, Colin Lloyd Barnes, Xiaohai Liu, John Milton, Xiaolin Wu, Harold Swerdlow
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Publication number: 20180363047Abstract: The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template.Type: ApplicationFiled: June 11, 2018Publication date: December 20, 2018Applicant: Illumina Cambridge LimitedInventors: Geoffrey Paul Smith, Jonathan Mark Boutell, Colin Lloyd Barnes, Roberto Rigatti, Niall Anthony Gormley, David Bentley, Tobias William Barr Ost, Vincent Peter Smith, Graham John Worsley, Eric Hans Vermaas
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Publication number: 20180353926Abstract: The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5? end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.Type: ApplicationFiled: June 18, 2018Publication date: December 13, 2018Applicant: Illumina Cambridge LimitedInventors: Xiaohai Liu, John Milton, Geoffrey Paul Smith, Colin Lloyd Barnes, Isabelle Rasolonjatovo, Roberto Rigatti, Xiaolin Wu, Tobias William Barr Ost, Graham John Worsley, David James Earnshaw, Gerardo Turcatti, Anthony Romieu
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Patent number: 9999866Abstract: The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5? end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.Type: GrantFiled: October 6, 2016Date of Patent: June 19, 2018Assignee: ILLUMINA CAMBRIDGE LIMITEDInventors: Xiaohai Liu, John Milton, Geoffrey Paul Smith, Colin Lloyd Barnes, Isabelle Rasolonjatovo, Roberto Rigatti, Xiaolin Wu, Tobias William Barr Ost, Graham John Worsley, David James Earnshaw, Gerardo Turcatti, Anthony Romieu
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Patent number: 9994896Abstract: The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template.Type: GrantFiled: December 17, 2014Date of Patent: June 12, 2018Assignee: ILLUMINA CAMBRIDGE LIMITEDInventors: Geoffrey Paul Smith, Jonathan Mark Boutell, Colin Lloyd Barnes, Roberto Rigatti, Niall Anthony Gormley, David Bentley, Tobias William Barr Ost, Vincent Peter Smith, Graham John Worsley, Eric Hans Vermaas
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Publication number: 20170361207Abstract: Internally illuminable playing cards are disclosed. The disclosed playing cards may include a polymeric body, at least one light-emitting diode (LED) at least partially inside of the polymeric body, a battery (or a slot in the polymeric body for receiving a battery) for providing power to the at least one LED, and a switch at least partially inside the polymeric body and operatively connected to the at least one LED to facilitate turning the at least one LED on and off. As can be understood based on this disclosure, the internally illuminable playing cards can be used for flourishing and cardistry techniques, in a manner similar to the way typical paper playing cards are used for such techniques.Type: ApplicationFiled: June 21, 2016Publication date: December 21, 2017Applicant: Ellusionist.com, Inc.Inventors: JASON BRUMBALOW, BRAD CHRISTIAN, ADAM WILBER, LLOYD BARNES, MIKE CLARKE, GERAINT CLARKE, PETER MCKINNON, DANIEL MADISON
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Publication number: 20170021325Abstract: The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5? end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.Type: ApplicationFiled: October 6, 2016Publication date: January 26, 2017Inventors: Xiaohai Liu, John Milton, Geoffrey Paul Smith, Colin Lloyd Barnes, Isabelle Rasolonjatovo, Roberto Rigatti, Xiaolin Wu, Tobias William Barr Ost, Graham John Worsley, David James Earnshaw, Gerardo Turcatti, Anthony Romieu
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Patent number: 9498763Abstract: The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5? end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.Type: GrantFiled: June 12, 2015Date of Patent: November 22, 2016Assignee: Illumina Cambridge LimitedInventors: Xiaohai Liu, John Milton, Geoffrey Paul Smith, Colin Lloyd Barnes, Isabelle Rasolonjatovo, Roberto Rigatti, Xiaolin Wu, Tobias William Barr Ost, Graham John Worsley, David James Earnshaw, Gerardo Turcatti, Anthony Romieu
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Publication number: 20150343410Abstract: The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5? end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.Type: ApplicationFiled: June 12, 2015Publication date: December 3, 2015Applicant: ILLUMINA CAMBRIDGE LIMITEDInventors: Xiaohai Liu, John Milton, Geoffrey Paul Smith, Colin Lloyd Barnes, Isabelle Rasolonjatovo, Roberto Rigatti, Xiaolin Wu, Tobias William Barr Ost, Graham John Worsley, David James Earnshaw, Gerardo Turcatti, Anthony Romieu
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Publication number: 20150203910Abstract: The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template.Type: ApplicationFiled: December 17, 2014Publication date: July 23, 2015Applicant: ILLUMINA CAMBRIDGE LIMITEDInventors: Geoffrey Paul Smith, Jonathan Mark Boutell, Colin Lloyd Barnes, Roberto Rigatti, Niall Anthony Gormley, David Bentley, Tobias William Barr Ost, Vincent Peter Smith, Graham John Worsley, Eric Hans Vermaas
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Patent number: 9085802Abstract: The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5? end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.Type: GrantFiled: January 28, 2014Date of Patent: July 21, 2015Assignee: Illumina Cambridge LimitedInventors: Xiaohai Liu, John Milton, Geoffrey Paul Smith, Colin Lloyd Barnes, Isabelle Marie Julia Rasolonjatovo, Roberto Rigatti, Xiaolin Wu, Tobias William Barr Ost, Graham John Worsley, David James Earnshaw, Gerardo Turcatti, Anthony Romieu
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Patent number: 8945835Abstract: The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template.Type: GrantFiled: April 11, 2012Date of Patent: February 3, 2015Assignee: Illumina Cambridge LimitedInventors: Eric Hans Vermaas, Graham John Worsley, Jonathan Mark Boutell, Colin Lloyd Barnes, Roberto Rigatti, Niall Anthony Gormley, Geoffrey Paul Smith, Vincent Peter Smith, Tobias William Barr Ost, David Bentley