Patents by Inventor Lloyd Charles Franklin

Lloyd Charles Franklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of Gamma-Amino Acids Having Affinity for The Alpha-2-Delta Protein
    Publication number: 20090299093
    Abstract: Disclosed are materials and methods for preparing optically active ?-amino acids of Formula 1, which bind to the alpha-2-delta (?2?) subunit of a calcium channel.
    Type: Application
    Filed: July 31, 2009
    Publication date: December 3, 2009
    Inventors: Margaret Claire Evans, Lloyd Charles Franklin, Lorraine Michelle Murtagh, Thomas Norman Nanninga, Bruce Allen Pearlman, James Edward Saenz, Niamh Josephine Willis
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Publication number: 20030225161
    Abstract: A compound of the formula 1
    Type: Application
    Filed: April 28, 2003
    Publication date: December 4, 2003
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6525096
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: February 25, 2003
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6414024
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: July 2, 2002
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6359169
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: March 19, 2002
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6342529
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: January 29, 2002
    Assignees: Northwestern University, Pfizer, Inc.
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6262120
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: July 17, 2001
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6255345
    Abstract: A compound of the formula wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: July 3, 2001
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • Single pot process for producing (Z)-azabicyclo oxime ethers
    Patent number: 6121459
    Abstract: Biologically active O-substituted azabicyclo oximes having the Z configuration may be isolated simply, without chromatographic separation, and in high yield and Z/E purity through the coupling of a 1-azabicyclo-3-one with an O-substituted hydroxylamine in acidic aqueous solution and conversion of E-configured isomer to Z-isomer without requiring purification or separation. Neutralization and subsequent isolation of the free base followed by precipitation of the salt allows separation of the Z-isomer with high Z/E purity.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: September 19, 2000
    Assignee: Warner-Lambert Company
    Inventors: Mark Alan Schwindt, Lloyd Charles Franklin, Haile Tecle
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6117906
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: September 12, 2000
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 6028214
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are also disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are further disclosed.
    Type: Grant
    Filed: April 21, 1998
    Date of Patent: February 22, 2000
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • Gaba and L-glutamic acid analogs for antiseizure treatment
    Patent number: 5847151
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: December 8, 1998
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 5710304
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: January 20, 1998
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt
  • GABA and L-glutamic acid analogs for antiseizure treatment
    Patent number: 5684189
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: April 12, 1995
    Date of Patent: November 4, 1997
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis Martin Sobieray, Lloyd Charles Franklin, Mark Alan Schwindt