Patents by Inventor Lloyd Dias

Lloyd Dias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid dispersions containing kinase inhibitors
    Patent number: 8557995
    Abstract: A solid dispersion comprises, in essentially non-crystalline form, a kinase inhibitory compound, e.g., N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N?-(3-fluorophenyl)urea, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a cancer.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: October 15, 2013
    Assignee: AbbVie Inc.
    Inventors: Jonathan M. Miller, Rajeev Gokhale, Eric A. Schmitt, Yi Gao, Justin Lafountaine, Lloyd Dias
  • Solid Dispersions Containing Kinase Inhibitors
    Publication number: 20110306632
    Abstract: A solid dispersion comprises, in essentially non-crystalline form, a kinase inhibitory compound, e.g., N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N?-(3-fluorophenyl)urea, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a cancer.
    Type: Application
    Filed: June 7, 2011
    Publication date: December 15, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Jonathan M. Miller, Rajeev Gokhale, Eric A. Schmitt, Yi Gao, Justin Lafountaine, Lloyd Dias