Patents by Inventor Lloyd E. Weeks

Lloyd E. Weeks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Discrete biochemical electrode system
    Patent number: 4230537
    Abstract: A biochemical device and method for the determination of dissolved gases in solution is provided which employs a dry electrode/sample interface. Dissolved oxygen or other gas concentration in a liquid sample is measured by its diffusion through a selectively permeable membrane which is an integral part of a disposable receptacle. The receptacle makes contact with a gas-sensing electrode at the locus of the selectively permeable membrane whereby the determination of the concentration of said gas is made by the electrode without ever touching the liquid sample.
    Type: Grant
    Filed: December 18, 1975
    Date of Patent: October 28, 1980
    Assignee: Monsanto Company
    Inventors: Jacques J. Delente, Lloyd E. Weeks
  • Triglycerides determination method
    Patent number: 4045297
    Abstract: A method of determining triglycerides in biological fluids which comprises reacting a biological fluid sample with a lipolytic enzyme to liberate free glycerol, reacting said free glycerol with a coupled enzyme series in an oxygenated aqueous solution containing ATP, GK, .alpha.-GPDH, NAD and an electron transfer agent, and measuring the uptake of oxygen by the oxidation of the resulting NADH with an oxygen-sensing electrode.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: August 30, 1977
    Assignee: Monsanto Company
    Inventors: Lloyd E. Weeks, John H. Johnson, Margaret J. Reents
  • Creatine phosphokinase determination method
    Patent number: 4042462
    Abstract: A method of determining creatine phosphokinase activity in biological fluids comprising reacting a biological fluid sample with a coupled enzyme series in an oxygenated aqueous solution containing creatine phosphate, ADP, glucose, HK, G-6-PDH, NADP and an electron transfer agent and measuring the uptake of oxygen by the oxidation of the resulting NADPH with an oxygen-sensing electrode.
    Type: Grant
    Filed: December 24, 1975
    Date of Patent: August 16, 1977
    Assignee: Monsanto Company
    Inventors: John H. Johnson, Lloyd E. Weeks
  • Dopamine-.beta.-hydroxylase determination method
    Patent number: 4032406
    Abstract: A method of determining dopamine-.beta.-hydroxylase (D.beta.H) activity in biological fluids which comprises reacting a D.beta.H-specific substrate with a sample of said biological fluid in the presence of ascorbate, fumarate and oxygen and measuring the uptake of oxygen by the resulting hydroxylation with an oxygen-sensing electrode.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: June 28, 1977
    Assignee: Monsanto Company
    Inventor: Lloyd E. Weeks
  • Preparing a reactor containing enzymes attached to dialdehyde cellulose
    Patent number: 4013514
    Abstract: Water-insoluble, biologically active conjugates for use in a reactor core of a flow-through reactor are prepared by covalently bonding an enzyme directly to a fibrous dialdehyde cellulose such as cotton. Preferably the fibrous cellulose is placed in the reactor core of a flow-through reactor before or after it is treated with periodic acid solution to convert glucose units thereof to units containing dialdehyde groups. Thereafter, an enzyme solution is passed through the resultant dialdehyde cellulose to bind the enzyme to the cellulose.
    Type: Grant
    Filed: January 2, 1974
    Date of Patent: March 22, 1977
    Assignee: Monsanto Company
    Inventors: Bernard S. Wildi, Lloyd E. Weeks
  • Lactate dehydrogenase determination method
    Patent number: 4006061
    Abstract: A method of determining lactate dehydrogenase activity in biological fluids comprising reacting a biological fluid sample with a coupled enzyme series in an oxygenated aqueous solution containing lactate, nicotinamide adenine dinucleotide and an electron transfer agent, and measuring the uptake of oxygen by the oxidation of the resulting NADH with an oxygen-sensing electrode.
    Type: Grant
    Filed: December 29, 1975
    Date of Patent: February 1, 1977
    Assignee: Monsanto Company
    Inventors: Lloyd E. Weeks, John H. Johnson