Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Abstract: The present invention provides methods of inhibiting Raf kinase activity in a patient, the method comprising administering to the patient a compound having formula I: or a pharmaceutically acceptable salt thereof, wherein Rx, Ry, R1, L1, L2, Cy1, and Cy2 are as defined as set forth in the specification.

Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

Abstract: Some embodiments include a method of switching between different methods (e.g., domains) of computing location of an end-user device. For example, the end-user device can retrieving a building model from a backend server system. The building model can characterize a building in the physical world. The end-user device can collect sensor data corresponding to the multiple interrelated domains utilizing sensor components. The end-user device can determine a position of the end-user device by computing a first location based on sensor data in a first domain and a first domain map that correlates to and align with a physical domain map. The end-user device can then compute a second location based on sensor data of a second domain of the multiple inter-related domains and a second domain map that correlates to and align with the physical domain map.

Abstract: Some embodiments include a method of providing an immersive virtual simulation. An end-user device can retrieve a building model from a backend server system. The building model can characterize a building in the physical world and have multiple inter-related domains of characterization including at least a radiofrequency (RF) domain map and/or a physical domain map. The end-user device can render a virtual simulation world. The virtual simulation world can include a virtual building structure based on the physical domain map. The end-user can collect inertial sensor data, wireless communication transceiver data, and/or virtual sensor data. The end-user device can then determine a position of the end-user device based on the collected data relative to the RF map and/or the physical domain map.

Abstract: Some embodiments include a method of detecting an anomaly when a computing device is navigating utilizing a location service application. The computing device can track its movement in a movement log by computing a device location relative to a site model. The tracked movement can include a sequence of device location samples. The computing device can identify, via a physics simulation engine, the device location as a position anomaly based on the tracked movement and the site model. The computing device can classify the position anomaly as a data anomaly or as a model anomaly. The computing device can compute a corrected device location based on the classification of the position anomaly.

Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

Abstract: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

Abstract: Disclosed are materials and methods for preparing optically active ?-amino acids of Formula 1, which bind to the alpha-2-delta (?2?) subunit of a calcium channel.

Abstract: This invention relates to compounds of the formula 1 wherein G, D, A, Z, Q, X, Y, R1, and R4 through R7 are defined as in the specification, processes for preparing the same and intermediates used in making the same, and pharmaceutical compositions containing such compounds and their use in the treatment of central nervous system disorders and other disorders.

Abstract: This invention relates to compounds of the formula 1 wherein G, D, A, Z, Q, X, Y, R1, and R4 through R7 are defined as in the specification, processes for preparing the same and intermediates used in making the same, and pharmaceutical compositions containing such compounds and their use in the treatment of central nervous system disorders and other disorders.

Abstract: This invention relates to compounds of the formula 1 wherein G, D, A, Z, Q, X, Y, R1, and R4 through R7 are defined as in the specification, processes for preparing the same and intermediates used in making the same, and pharmaceutical compositions containing such compounds and their use in the treatment of central nervous system disorders and other disorders.

Abstract: The system includes a flexible button top which has a sleeve appurtenance which is force-fitted over an externally helically grooved stud assembly having an integral self-adhesive back mounting plate. The button top is flexible enough so that it can be applied to, and removed from the stud assembly without the use of a tool, yet it is hard enough so that the stud will not perforate the flexible button top when impacted. The adhesive-backed stud assembly includes a helically threaded metallic screw perpendicularly attached to a metallic circular disc with a plastic foam backing impregnated with adhesive. The adhesive backing is covered by a release film prior to use. The adhesive-backed stud assembly can be applied without the use of a tool.