Patents by Inventor Lloyd G. Tillman

Lloyd G. Tillman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PULSATILE RELEASE COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL DRUG ABSORPTION
    Publication number: 20110256217
    Abstract: Delayed release oral pharmaceutical formulations and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a penetration enhancer which are released at a first location in the intestine, and a second population of carrier particles comprising a penetration enhancer and a delayed release coating or matrix. This penetration enhancer is released at a second location in the intestine downstream from the first location and enhances absorption of the drug when it reaches the second location.
    Type: Application
    Filed: June 16, 2009
    Publication date: October 20, 2011
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Susan Weinbach, Lloyd G. Tillman, Richard S. Geary, Gregory E. Hardee
  • Pulsatile release compositions and methods for enhanced intestinal oligonucleotide drug absorption
    Patent number: 7576067
    Abstract: Delayed release oral pharmaceutical formulations and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a penetration enhancer which are released at a first location in the intestine, and a second population of carrier particles comprising a penetration enhancer and a delayed release coating or matrix. This penetration enhancer is released at a second location in the intestine downstream from the first location and enhances absorption of the drug when it reaches the second location.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: August 18, 2009
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Susan Weinbach, Lloyd G. Tillman, Richard S. Geary, Gregory E. Hardee
  • Pulsatile release compositions and methods for enhanced intestinal drug absorption
    Publication number: 20030124196
    Abstract: Delayed release oral pharmaceutical formulations and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a penetration enhancer which are released at a first location in the intestine, and a second population of carrier particles comprising a penetration enhancer and a delayed release coating or matrix. This penetration enhancer is released at a second location in the intestine downstream from the first location and enhances absorption of the drug when it reaches the second location.
    Type: Application
    Filed: August 22, 2001
    Publication date: July 3, 2003
    Inventors: Susan Weinbach, Lloyd G. Tillman, Richard S. Geary, Gregory E. Hardee
  • Bioadhesive compositions and methods for enhanced intestinal drug absorption
    Publication number: 20030083286
    Abstract: Compositions and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a bioadhesive compound and a second population of carrier particles comprising a penetration enhancer. The bioadhesive extends the residence time of the drug and its absorptive potential across the portion of the intestinal mucosa made permeable by the penetration enhancer.
    Type: Application
    Filed: August 22, 2001
    Publication date: May 1, 2003
    Inventors: Ching-Leou Teng, Susan Weinbch, Lloyd G. Tillman, Richard S. Geary, Gregory E. Hardee
  • Multiparticulate formulation
    Publication number: 20030027780
    Abstract: The present invention is related to non-parenteral multiparticulate formulations capable of transporting therapeutic, prophylactic and diagnostic agents across mucosal membranes such as gastrointestinal, buccal, nasal, rectal and vaginal. Formulations comprise a plurality of carrier particles, an agent to be delivered across a mucosal membrane, and a penetration enhancer. The drug is adhered to the surface of the carrier particle or is impregnated within by electrostatic, covalent or mechanical forces.
    Type: Application
    Filed: February 8, 2002
    Publication date: February 6, 2003
    Inventors: Gregory E. Hardee, Lloyd G. Tillman, Maria Gonzalez-Ferreiro, Rahul C. Mehta, Ching-Leou Teng