Abstract: A composition for the prevention or inhibition of free-radical-induced effects on the skin comprises (a) ascorbic acid, or a salt, ester, glucoside, glucosamine and/or other derivative thereof; (b) tocopherol, or an ester and/or other derivative thereof; and (c) at least one further anti-oxidant agent selected from the group consisting of: carotenoids; ?-lipoic acid and salts thereof; green tea extract; hibiscus (Sudanese) tea extract; rooibus tea extract; embilica extract; rosehip extract; elderflower extract; and grape seed extract. The composition preferably comprises ?-lipoic acid, or a salt thereof, and carotenoids, and is preferably administered orally, to provide systematic protection to the skin.