Patents by Inventor Lloyd Old

Lloyd Old has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Membrane transporter NaPi2b (SCL34A1) epitope for antibody therapy, antibodies directed thereto, and target for cancer therapy
    Patent number: 8603474
    Abstract: The present disclosure relates generally to the membrane transporter NaPi2b (SLC34A2) as a target for therapy, including immunotherapy, and particularly cancer therapy. The SLC34A2 epitope peptide encompassing amino acids 312-340 of SLC34A2 has been identified as an ovarian cancer epitope using the monoclonal antibody MX35. The invention also relates to the use of SLC34A2 and particularly SLC34A2 peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against NaPi2b (SLC34A2) and the SLC34A2 peptide(s), including veneered, chimeric, single chain and humanized antibodies. Methods for generating an immune response and for treatment of tumors and cancer are also provided. Assays for screening and identifying compounds directed against SLC34A2, including the SLC34A2 epitope peptide, and additional antibodies are provided.
    Type: Grant
    Filed: January 29, 2009
    Date of Patent: December 10, 2013
    Assignees: Ludwig Institute for Cancer Research, Ltd., Institute of Molecular Biology and Genetics National Academy of Science of Ukraine, Sloan-Kettering Institute for Cancer Research
    Inventors: Gerd Ritter, Beatrice Yin, Anne Murray, George Mark, Lloyd Old, Kenneth Lloyd, Serhiy Souchelnytskiy, Ivan Gout, Valeriy Filonenko, Ramziya Kiyamova
  • A34 and A33-like 3 DNA protein, antibodies thereto and methods of treatment using same
    Patent number: 8440807
    Abstract: Polynucleotide molecules and polypeptide molecules A34 and A33-like 3 are described, as well as antibodies to polypeptide molecules A34 and A33-like 3. Also described are methods of detecting cancers expressing these polypeptides, and methods and kits for diagnosing said cancers, and methods of inhibiting effects of a cancer in a patient.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: May 14, 2013
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Gerd Ritter, Lloyd Old, Achim Jungbluth, Cynthia H. Scanlan
  • A34 AND A33-LIKE 3 DNA PROTEIN, ANTIBODIES THERETO AND METHODS OF TREATMENT USING SAME
    Publication number: 20120039892
    Abstract: Polynucleotide molecules and polypeptide molecules A34 and A33-like 3 are described, as well as antibodies to polypeptide molecules A34 and A33-like 3. Also described are methods of detecting cancers expressing these polypeptides, and methods and kits for diagnosing said cancers, and methods of inhibiting effects of a cancer in a patient.
    Type: Application
    Filed: September 15, 2011
    Publication date: February 16, 2012
    Applicant: Ludwig Institute for Cancer Research
    Inventors: Matthew Scanlan, Cynthia H. Scanlan, Gerd Ritter, Lloyd Old, Achim Jungbluth
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Patent number: 8071717
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: December 6, 2011
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Dirk Jager, Elisabeth Stockert, Matthew Scanlan, Alexander Knuth, Lloyd Old, Ali Gure, Yao-Tseng Chen, Elke Jager
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Publication number: 20100278850
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Application
    Filed: October 27, 2009
    Publication date: November 4, 2010
    Inventors: Dirk Jager, Elisabeth Stockert, Matthew Scanlan, Alexander Knuth, Lloyd Old, Ali Gure, Yao-Tseng Chen, Elke Jager
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per SE, and uses thereof
    Patent number: 7795409
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: September 14, 2010
    Assignees: Ludwig Institute for Cancer Research, Cornell Research Foundation, Inc.
    Inventors: Dirk Jager, Elisabeth Stockert, Barry C. Picker, legal representative, Matthew Scanlan, Cynthia H. Scanlan, legal representative, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-Tseng Chen
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Patent number: 7622568
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Grant
    Filed: November 12, 2007
    Date of Patent: November 24, 2009
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Dirk Jager, Elisabeth Stockert, Matthew Scanlan, Alexander Knuth, Lloyd Old, Ali Gure, Yao-Tseng Chen, Elke Jager
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per SE, and uses thereof
    Publication number: 20090203123
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Application
    Filed: January 30, 2008
    Publication date: August 13, 2009
    Inventors: Dirk Jager, Elisabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-Tseng Chen, Barry C. Picker, Cynthia H. Scanlan
  • A34 and A33-like 3 DNA, proteins, antibodies thereto and methods of treatment using same
    Patent number: 7521543
    Abstract: Polynucleotide molecules and polypeptide molecules A34 and A33-like 3 are described, as well as antibodies to polypeptide molecules A34 and A33like 3. Also described are methods of detecting cancers expressing these polypeptides, and methods and kits for diagnosing said cancers, and methods of inhibiting effects of a cancer in a patient.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: April 21, 2009
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Cynthia Scanlan, legal representative, Gerd Ritter, Lloyd Old, Achim Jungbluth, Matthew Scanlan
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Publication number: 20080177031
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Application
    Filed: November 12, 2007
    Publication date: July 24, 2008
    Inventors: Dirk Jager, Elisabeth Stockert, Matthew Scanlan, Alexander Knuth, Lloyd Old, Ali Gure, Yao-Tseng Chen, Elke Jager
  • METHODS AND COMPOSITIONS FOR INCREASED PRIMING OF T-CELLS THROUGH CROSS-PRESENTATION OF EXOGENOUS ANTIGENS
    Publication number: 20080171059
    Abstract: Methods for eliciting in an animal in need thereof a cell-mediated immune response specific to an antigen, the method comprising providing an antigen preparation comprising particles on the surface of which the antigen is attached, and administering the antigen preparation to the animal, wherein the particles are taken up by antigen presenting cells (APC) of the animal via phagocytosis, forming a phagosome inside the APC, wherein the antigen is attached to the surface of the particle in such a way that the antigen is released in the phagosome before the phagosome fuses with a late endosome or a lysosome, and wherein the antigen is cross-presented on a Class I MHC molecule. Also provided are particulate antigen preparations or particulate vaccines that can be delivered to an animal in need thereof for vaccination against, for preventing or treating, a disease related to the antigen, such as cancer and a viral infection.
    Type: Application
    Filed: August 7, 2007
    Publication date: July 17, 2008
    Inventors: Shanshan Wu Howland, Lloyd Old, K. Dane Wittrup
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Patent number: 7354992
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Grant
    Filed: December 4, 2003
    Date of Patent: April 8, 2008
    Assignees: Ludwig Institute For Cancer Research, Cornell Research Foundation, Inc.
    Inventors: Dirk Jager, Barry C. Picker, legal representative, Cynthia H. Scanlan, legal representative, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-Tseng Chen, Elisabeth Stockert, Matthew Scanlan
  • A34 and a33-Like 3dna, proteins, antibodies thereto and methods of treatment using same
    Publication number: 20060292154
    Abstract: Polynucleotide molecules and polypeptide molecules A34 and A33-like 3 are described, as well as antibodies to polypeptide molecules A34 and A33like 3. Also described are methods of detecting cancers expressing these polypeptides, and methods and kits for diagnosing said cancers, and methods of inhibiting effects of a cancer in a patient.
    Type: Application
    Filed: October 23, 2003
    Publication date: December 28, 2006
    Applicant: Ludwig Institute for Cancer Research
    Inventors: Matthew Scanlan, Cynthia Scanlan, Gerd Ritter, Lloyd Old, Achim Jungbluth
  • Isolated peptides corresponding to amino acid requirements of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof
    Publication number: 20060269960
    Abstract: The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
    Type: Application
    Filed: August 4, 2006
    Publication date: November 30, 2006
    Inventors: Alexander Knuth, Elke Jager, Yao-tseng Chen, Matthew Scanlan, Ali Gure, Gerd Ritter, Lloyd Old, Jan Drijfhout
  • Isolated cancer associated antigens NY-MEL 1 and NY-MEL 3, peptides based thereon, and their uses
    Patent number: 7132507
    Abstract: The invention relates to isolated, cancer associated antigens, nucleic acid molecules, and various uses thereof.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: November 7, 2006
    Assignees: Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, Cornell Research Foundation, Inc.
    Inventors: Dirk Jager, Elizabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-Tseng Chen
  • Method for generating an immune response and reagents therefor
    Publication number: 20060204507
    Abstract: Isolated peptides are disclosed which, when processed, generate a coordinated immune response.
    Type: Application
    Filed: September 26, 2003
    Publication date: September 14, 2006
    Inventors: Lloyd Old, Sacha Gnjatic
  • Cancer-testis antigens
    Publication number: 20060089303
    Abstract: Cancer-testis (CT) antigens have been identified by screening public databases for transcripts that are expressed in tumor tissues and a limited set of normal tissues, or by screening for genes that are expressed in cancer and testis tissues (but not other normal tissues). The invention relates to nucleic acids and encoded polypeptides which are CT antigens expressed in patients afflicted with cancer. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided.
    Type: Application
    Filed: September 29, 2005
    Publication date: April 27, 2006
    Applicants: Ludwig Institute for Cancer Research, Cornell Research Foundation, Inc.
    Inventors: Lloyd Old, Matthew Scanlan, Cynthia Scanlan, Yao-Tseng Chen
  • EGF receptor epitope peptides and uses thereof
    Publication number: 20050255555
    Abstract: The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided.
    Type: Application
    Filed: February 17, 2005
    Publication date: November 17, 2005
    Inventors: Terrance Johns, Andrew Scott, Antony Burgess, Lloyd Old, Timothy Adams, K. Wittrup, Ginger Chao
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Patent number: 6911529
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also part of this invention.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: June 28, 2005
    Assignees: Ludwig Institute for Cancer Research, Cornell Research Foundation, Memorial Sloan-Kettering Cancer Center
    Inventors: Dirk Jager, Elizabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-tseng Chen
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Publication number: 20050063981
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Application
    Filed: December 4, 2003
    Publication date: March 24, 2005
    Inventors: Dirk Jager, Elisabeth Stockert, Barry Picker, Matthew Scanlan, Cynthia Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-Tseng Chen