Abstract: The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A). Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

Abstract: Methods and apparatuses for improving the performance and energy efficiency of machine learning systems that generate security specific machine learning models and generate security related information using security specific machine learning models are described. A security specific machine learning model may comprise a security specific large language model (LLM). The security specific LLM may be trained and deployed to generate semantically related security information. The security specific LLM may be pretrained with a security specific data set that was generated using similarity deduplication and long line handling, and with security specific objectives, such as next log line prediction based on host, system, application, and cyber attacker behavior. The security specific large language model may be fine-tuned using a security specific similarity dataset that may be generated to align the security specific LLM to capture similarity between different security events.

Abstract: A filament circuit resistance adjusting apparatus (36), for a filament circuit (38) having a filament (50) with a first resistance is provided. The filament circuit resistance adjusting apparatus (36) includes a first resistor (70), which has a second resistance and is electrically coupled to the filament (50). The first resistor (70) adjusts the resistance of the filament circuit (38). A method for adjusting the resistance of the filament (50) is also provided.

Abstract: A filament circuit resistance adjusting apparatus (36), for a filament circuit (38) having a filament (50) with a first resistance is provided. The filament circuit resistance adjusting apparatus (36) includes a first resistor (70), which has a second resistance and is electrically coupled to the filament (50). The first resistor (70) adjusts the resistance of the filament circuit (38). A method for adjusting the resistance of the filament (50) is also provided.