Abstract: A water filtration apparatus and a method of using thereof, wherein the water filtration apparatus includes a nanoparticle layer which comprises polypeptide-functionalized nanoparticles that are capable of absorbing heavy metals selected from the group consisting of Pb2+, As5+, Cd2+, Hg2+, Cr6+, Cu2+, and Zn2+, as well as organic materials. Various embodiments of the water filtration apparatus, the method of using the apparatus, and a method of producing the polypeptide-functionalized nanoparticles are also provided.

Abstract: A water filtration apparatus and a method of using thereof, wherein the water filtration apparatus includes a nanoparticle layer which comprises polypeptide-functionalized nanoparticles that are capable of absorbing heavy metals selected from the group consisting of Pb2+, As5+, Cd2+, Hg2+, Cr6+, Cu2+, and Zn2+, as well as organic materials. Various embodiments of the water filtration apparatus, the method of using the apparatus, and a method of producing the polypeptide-functionalized nanoparticles are also provided.

Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, in which each compound is adapted to occupy the binding site of human IDO, which comprises a large hydrophobic pocket A and a second, proximal hydrophobic pocket B, the compound comprising at least one of the following elements: (i) a large hydrophobic fragment to substantially fill pocket A in the binding site of human IDO; (ii) an atom that can coordinate to the heme iron of human IDO, (iii) a positively charged group that can form a salt-bridge with the heme 7-propionate of the human IDO; (iv) a negatively charged group that can form a salt-bridge with Arg231 of the human IDO; (v) a hydrophobic group that can form van der Waals interactions with pocket B; and (vi) one or more substituents that can hydrogen bond to Ser167 and to Gly262, and as IDO inhibitors and their therapeutic use, eg in the treatment of cancer.