Patents by Inventor Loc Thanh Tran

Loc Thanh Tran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of CCR5 receptor antagonists
    Patent number: 7728135
    Abstract: The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: June 1, 2010
    Assignee: Schering Corporation
    Inventors: Xiongwei Shi, Man Zhu, William Leong, Vilas Dahanukar, Ilia A. Zavialov, Cecelia Proietti, Shannon Zhao, Hong-Chang Lee, Yi Liu, Hoa N. Nguyen, Wenxue Wu, Bosco D'Sa, Feng Liang, Loc Thanh Tran
  • SYNTHESIS OF CCR5 RECEPTOR ANTAGONISTS
    Publication number: 20100036125
    Abstract: The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
    Type: Application
    Filed: October 16, 2009
    Publication date: February 11, 2010
    Inventors: Xiongwei Shi, Man Zhu, William Leong, Vilas Dahanukar, Ilia A. Zavialov, Cecilia Proietti, Shannon Zhao, Hong-Chang Lee, Yi Liu, Hoa N. Nguyen, Wenxue Wu, Bosco D'Sa, Feng Liang, Loc Thanh Tran
  • PROCESS FOR PREPARING SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINES
    Publication number: 20090326241
    Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.
    Type: Application
    Filed: September 2, 2009
    Publication date: December 31, 2009
    Inventors: Shen-Chun Kuo, David Jieh-Shyh Tsai, Loc Thanh Tran, Pengyi Zhang, Andrew D. Jones
  • Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines
    Patent number: 7601833
    Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: October 13, 2009
    Assignee: Schering Corporation
    Inventors: Shen-Chun Kuo, David Jieh-Shyh Tsai, Loc Thanh Tran, Pengyi Zhang, Andrew D. Jones
  • PROCESS FOR PREPARING SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINES
    Publication number: 20090131663
    Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed.
    Type: Application
    Filed: January 27, 2009
    Publication date: May 21, 2009
    Inventors: Shen-Chun Kuo, Loc Thanh Tran, Pengyi Zhang
  • Preparation of pharmaceutical salts of piperazine compounds
    Patent number: 7521452
    Abstract: The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: April 21, 2009
    Assignee: Schering Corporation
    Inventors: Wenxue Wu, Loc Thanh Tran, Bosco D'Sa, Feng Liang, William Leong, Hong-Chang Lee, Kevin Klopfer, Vijay Sabesen
  • PREPARATION OF PHARMACEUTICAL SALTS OF PIPERAZINE COMPOUNDS
    Publication number: 20090093496
    Abstract: The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer.
    Type: Application
    Filed: December 10, 2008
    Publication date: April 9, 2009
    Inventors: Wenxue Wu, Loc Thanh Tran, Bosco D'Sa, Feng Liang, William Leong, Hong-Chang Lee, Kevin Klopfer, Vijay Sabesan
  • Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines
    Patent number: 7507822
    Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: March 24, 2009
    Assignee: Schering Corporation
    Inventors: Shen-Chun Kuo, Loc Thanh Tran, Pengyi Zhang
  • PROCESS FOR PREPARING SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINES
    Publication number: 20090005559
    Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.
    Type: Application
    Filed: September 11, 2008
    Publication date: January 1, 2009
    Inventors: Shen-Chun Kuo, David Jieh-Shyh Tsai, Loc Thanh Tran, Pengyi Zhang, Andrew D. Jones
  • Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines
    Patent number: 7439361
    Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: October 21, 2008
    Assignee: Schering Corporation
    Inventors: Shen-Chun Kuo, David Jieh-Shyh Tsai, Loc Thanh Tran, Pengyi Zhang, Andrew D. Jones
  • Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines
    Publication number: 20070203340
    Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.
    Type: Application
    Filed: April 20, 2007
    Publication date: August 30, 2007
    Inventors: Shen-Chun Kuo, David Jieh-Shyh Tsai, Loc Thanh Tran, Pengyi Zhang, Andrew Jones
  • Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines
    Patent number: 7235659
    Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed.
    Type: Grant
    Filed: November 29, 2004
    Date of Patent: June 26, 2007
    Assignee: Schering Corporation
    Inventors: Shen-Chun Kuo, Loc Thanh Tran, Pengyi Zhang
  • Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidines
    Patent number: 7223861
    Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.
    Type: Grant
    Filed: October 26, 2004
    Date of Patent: May 29, 2007
    Assignee: Schering Corporation
    Inventors: Shen-Chun Kuo, David Jieh-Shyh Tsai, Loc Thanh Tran, Pengyi Zhang, Andrew D. Jones