Abstract: Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidin-1 -yl)-[1,2,4]triazolo[4,3-b]pyridazine of formula (Ib), which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b] [1,4]dioxin-6-yl)oxy)piperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine, i.e. 7-(4-((phenyl or pyridin-3-yl)oxy)piperidin-1-yl)-4H-pyrimido[1,2-b]pyridazin-4-one derivatives of formula (I) which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: Disclosed herein are 2,3,5-trifluorophenyl-pyridazine substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4) Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: Disclosed herein are substituted 2-azaspiro[3.3]heptane compounds of formula (I?), which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: Disclosed herein are substituted 2-azaspiro[3.3]heptane compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.

Abstract: The present invention provides apparatus for dispensing ophthalmic lens packages. A plurality of ophthalmic lens packages are loaded into the apparatus and the apparatus determines an identity of each ophthalmic lens package. A housing stores the ophthalmic lens packages and records a location and identity of each of the lens packages and dispenses a particular ophthalmic lens package.

Abstract: An automatic switch control includes a wheel member having a cam member with a ramp surface. A first plunger mechanism has a first spring member that is operable to urge a first cam follower into sliding engagement with the ramp surface. A second plunger mechanism has a second spring member that is operable to urge a second cam follower into sliding engagement with the ramp surface. The second plunger mechanism is disposed on an opposite side of the toggle from the first plunger mechanism when the automatic switch control is installed over the switch. An electric motor is operable to rotate the cam member to position the first plunger mechanism in a retracted condition and to position the second plunger mechanism in an extended condition that is operable to move the toggle to the on position.

Abstract: A shredder including a shredding mechanism, a housing at least partially enclosing the shredding mechanism, and a receptacle that receives and contains shredded material is provided. The shredder may further includes a compactor including a ram that, when actuated, moves through the receptacle to compress shredded material in the receptacle. The shredder may further include a foot operated lever coupled to the compactor to actuate the ram. The compactor may also include a scissor mechanism that guides the ram through the receptacle.

Abstract: An apparatus for dispensing ophthalmic lens packages and methods of its use are described herein.

Abstract: An automatic switch control fits over a switch on a wall to move a toggle of the switch between an on position and an off position. The automatic switch control generally includes a housing and a wheel member rotatably supported by the housing. The wheel member has a cam member with a ramp surface. An electric motor is operable to rotate the wheel member about an axis of rotation that is generally perpendicular to the wall. A first plunger mechanism has a first spring member that is operable to urge a first cam follower into sliding engagement with the ramp surface. A second plunger mechanism has a second spring member that is operable to urge a second cam follower into sliding engagement with the ramp surface. The second plunger mechanism is disposed on an opposite side of the toggle from the first plunger mechanism when the automatic switch control is installed over the switch.

Abstract: A shredder including a shredding mechanism, a housing at least partially enclosing the shredding mechanism, and a receptacle that receives and contains shredded material is provided. The shredder may further includes a compactor including a ram that, when actuated, moves through the receptacle to compress shredded material in the receptacle. The shredder may further include a foot operated lever coupled to the compactor to actuate the ram. The compactor may also include a scissor mechanism that guides the ram through the receptacle.

Abstract: A shredder including a shredding mechanism, a housing at least partially enclosing the shredding mechanism, and a receptacle that receives and contains shredded material is provided. The shredder may further includes a compactor including a ram that, when actuated, moves through the receptacle to compress shredded material in the receptacle. The shredder may further include a foot operated lever coupled to the compactor to actuate the ram. The compactor may also include a scissor mechanism that guides the ram through the receptacle.