Abstract: An orthopedic guide may include a guide body configured to couple with a bone of a patient, a guide feature associated with the guide body configured to guide a surgical instrument relative to the bone, and a bone-facing surface associated with the guide body comprising a patient-specific surface formed thereon and corresponding to an anatomical feature of the bone. The patient-specific surface may be configured to position the guide feature at a desired orientation relative to the bone as the patient-specific surface engages the anatomical feature on the bone.

Abstract: A bone reaming system may include a reamer guide plate and a reamer head. The reamer guide plate may include a guide plate body having a bone-facing surface, a superior surface opposite the bone-facing surface, and a reamer guide bore formed through the guide plate body. The reamer head may include a distal cutting surface with one or more cutting features, as well as one or more stop members coupled to a proximal end of the reamer head. The reamer guide bore may be shaped to receive and guide the distal cutting surface of the reamer head placed through the reamer guide bore. The one or more stop members may be configured to contact the superior surface of the guide plate body to limit a predetermined depth of the distal cutting surface projecting from the bone-facing surface of the guide plate body.

Abstract: One aspect of the present invention is directed to triblock peptides comprising a lipid moiety, a peptide block and a zwitterion-like block. Another aspect of the invention is directed to pharmaceutical compositions comprising the triblock peptides of the present in invention arranged in micelles in a pharmaceutically acceptable carrier. In certain embodiments, the pharmaceutical compositions of the present invention are vaccine compositions, which may further comprise an adjuvant. Another aspect of the invention is directed to methods of using the triblock peptides and compositions of the invention to treat a disease or condition.

Abstract: One aspect of the present invention is directed to triblock peptides comprising a lipid moiety, a peptide block and a zwittenon-like block. Another aspect of the invention is directed to pharmaceutical compositions comprising the triblock peptides of the present in invention arranged in micelles in a pharmaceutically acceptable carrier. In certain embodiments, the pharmaceutical compositions of the present invention are vaccine compositions, which may further comprise an adjuvant. Another aspect of the invention is directed to methods of using the triblock peptides and compositions of the invention to treat a disease or condition.