Patents by Inventor Loise M. Francisco

Loise M. Francisco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulatory T cell PD-1 modulation for regulating T cell effector immune responses
    Patent number: 11207393
    Abstract: The present invention is based, in part, on the identification of methods of modulating PD-1 expression and/or activity in regulatory T cells (Tregs) to thereby regulate effector immune responses in effector T cells (Teffs).
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: December 28, 2021
    Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Arlene H. Sharpe, Gordon J. Freeman, Loise M. Francisco, Peter T. Sage, Sun J. Lee, Scott B. Lovitch, Vikram R. Juneja, Catherine L. Tan
  • Compositions and methods for modulating an immune response
    Patent number: 10577586
    Abstract: The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses, follicular helper T (TFH) cell-mediated immune responses or both, and the use of those methods in the treatment of diseases or conditions mediated by TFR or TFH cells. The invention also provides novel methods for identifying TFR and TFH cells in a population of cells. The invention also provides compositions comprising TFR cells that have enhanced suppressive activity as compared wild type TFR cells. The invention also provides compositions comprising T follicular regulatory (TFR) cells isolated from the peripheral blood of a subject wherein the composition is enriched for TFR cells. Methods of making and using the compositions of the invention to modulate an immune response are also provided.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: March 3, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Arlene H. Sharpe, Peter T. Sage, Loise M. Francisco
  • REGULATORY T CELL PD-1 MODULATION FOR REGULATING T CELL EFFECTOR IMMUNE RESPONSES
    Publication number: 20180303922
    Abstract: The present invention is based, in part, on the identification of methods of modulating PD-1 expression and/or activity in regulatory T cells (Tregs) to thereby regulate effector immune responses in effector T cells (Teffs).
    Type: Application
    Filed: October 14, 2016
    Publication date: October 25, 2018
    Inventors: Arlene H. Sharpe, Gordon J. Freeman, Loise M. Francisco, Peter T. Sage, Sun J. Lee, Scott B. Lovitch, Vikram R. Juneja, Catherine L. Tan
  • Compositions and Methods for Modulating an Immune Response
    Publication number: 20180230428
    Abstract: The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses, follicular helper T (TFH) cell-mediated immune responses or both, and the use of those methods in the treatment of diseases or conditions mediated by TFR or TFH cells. The invention also provides novel methods for identifying TFR and TFH cells in a population of cells. The invention also provides compositions comprising TFR cells that have enhanced suppressive activity as compared wild type TFR cells. The invention also provides compositions comprising T follicular regulatory (TFR) cells isolated from the peripheral blood of a subject wherein the composition is enriched for TFR cells. Methods of making and using the compositions of the invention to modulate an immune response are also provided.
    Type: Application
    Filed: February 5, 2018
    Publication date: August 16, 2018
    Inventors: Arlene H. Sharpe, Peter T. Sage, Loise M. Francisco
  • Compositions and methods for modulating an immune response
    Patent number: 9885016
    Abstract: The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses, follicular helper T (TFH) cell-mediated immune responses or both, and the use of those methods in the treatment of diseases or conditions mediated by TFR or TFH cells. The invention also provides novel methods for identifying TFR and TFH cells in a population of cells. The invention also provides compositions comprising TFR cells that have enhanced suppressive activity as compared wild type TFR cells. The invention also provides compositions comprising T follicular regulatory (TFR) cells isolated from the peripheral blood of a subject wherein the composition is enriched for TFR cells. Methods of making and using the compositions of the invention to modulate an immune response are also provided.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: February 6, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Arlene H. Sharpe, Peter T. Sage, Loise M. Francisco
  • Methods and Compositions for the Generation and Maintenance of Regulatory T Cells
    Publication number: 20170165325
    Abstract: Methods and compositions for generating and maintaining induced regulatory T cells (iTregs) are provided. Methods and compositions for treating an autoimmune disorder, organ transplant rejection, graft versus host disease or allergic or hypersensitivity and inflammation are also provided.
    Type: Application
    Filed: February 24, 2017
    Publication date: June 15, 2017
    Inventors: Arlene Sharpe, Loise M. Francisco, Vijay Kuchroo
  • Methods and compositions for the generation and maintenance of regulatory T cells
    Patent number: 9580684
    Abstract: Methods and compositions for generating and maintaining induced regulatory T cells (iTregs) are provided. Methods and compositions for treating an autoimmune disorder, organ transplant rejection, graft versus host disease or allergic or hypersensitivity and inflammation are also provided.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: February 28, 2017
    Assignees: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Arlene Sharpe, Loise M. Francisco, Vijay Kuchroo
  • Compositions and Methods for Modulating an Immune Response
    Publication number: 20160032245
    Abstract: The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses, follicular helper T (TFH) cell-mediated immune responses or both, and the use of those methods in the treatment of diseases or conditions mediated by TFR or TFH cells. The invention also provides novel methods for identifying TFR and TFH cells in a population of cells. The invention also provides compositions comprising TFR cells that have enhanced suppressive activity as compared wild type TFR cells. The invention also provides compositions comprising T follicular regulatory (TFR) cells isolated from the peripheral blood of a subject wherein the composition is enriched for TFR cells. Methods of making and using the compositions of the invention to modulate an immune response are also provided.
    Type: Application
    Filed: May 8, 2015
    Publication date: February 4, 2016
    Inventors: Arlene H. Sharpe, Peter T. Sage, Loise M. Francisco
  • Methods and Compositions for the Generation and Maintenance of Regulatory T Cells
    Publication number: 20120076805
    Abstract: Methods and compositions for generating and maintaining induced regulatory T cells (iTregs) are provided. Methods and compositions for treating an autoimmune disorder, organ transplant rejection, graft versus host disease or allergic or hypersensitivity and inflammation are also provided.
    Type: Application
    Filed: September 1, 2011
    Publication date: March 29, 2012
    Applicants: The Brigham and Women's Hospital, Inc., Presidents and Fellows of Harvard College
    Inventors: Arlene Sharpe, Loise M. Francisco, Vijay Kuchroo