Patents by Inventor Lokender KUMAR

Lokender KUMAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF PURIFYING ACTIVE SOLUBLE MATRIX METALLOPROTEINASES
    Publication number: 20210348148
    Abstract: A method for purifying activated human MMP in E. coli without the use of urea or APMA is provided. In the method, a non-ionic detergent is used in a lysis buffer to solubilize MMP, and the protease activities of trypsin and MMP are utilized to digest the E. coli proteins and activate pro-MMP1.
    Type: Application
    Filed: July 19, 2021
    Publication date: November 11, 2021
    Inventors: Lokender KUMAR, Susanta K. SARKAR
  • Methods of making antimicrobial biopolymer from sodium alginate and algae extract using aminoglycosides, and methods of using the same
    Patent number: 11027019
    Abstract: Methods of forming antimicrobial biopolymers from sodium alginate and algae extract using aminoglycosides are presented. Also presented are improved biopolymers, methods of making the biopolymers, and methods of using the biopolymers, wherein the biopolymer includes a sodium alginate and an aminoglycoside.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: June 8, 2021
    Inventors: Lokender Kumar, John Brice, Linda Toberer, Judith Klein-Seetharaman, Daniel Knauss, Susanta Kumar Sarkar
  • METHODS OF MAKING ANTIMICROBIAL BIOPOLYMER FROM SODIUM ALGINATE AND ALGAE EXTRACT USING AMINOGLYCOSIDES, AND METHODS OF USING THE SAME
    Publication number: 20200129622
    Abstract: Methods of forming antimicrobial biopolymers from sodium alginate and algae extract using aminoglycosides are presented. Also presented are improved biopolymers, methods of making the biopolymers, and methods of using the biopolymers, wherein the biopolymer includes a sodium alginate and an aminoglycoside.
    Type: Application
    Filed: October 31, 2019
    Publication date: April 30, 2020
    Inventors: Lokender Kumar, John Brice, Linda Toberer, Judith Klein-Seetharaman, Daniel Knauss, Susanta Kumar Sarkar
  • METHOD OF PREVENTING OR REDUCING BIOFILM FORMATION
    Publication number: 20190282677
    Abstract: A method of disrupting or reducing a biofilm, the methods comprising contacting the biofilm with a matrix metalloproteinase (MMP). The biofilm may be present on inanimate or biological surfaces. Also, the MMP may be used to prevent the growth of a biofilm on an item, such as a medical device, by applying the MMP to the item. Also, therapeutic compositions comprising the MMP, which may be used to treat an individual having a biofilm-associated disease or disorder.
    Type: Application
    Filed: March 15, 2019
    Publication date: September 19, 2019
    Inventors: Lokender KUMAR, Susanta K. SARKAR
  • PURIFICATION OF ACTIVE SOLUBLE RECOMBINANT MATRIX METALLOPROTEINASE IN ESCHERICHIA COLI
    Publication number: 20190233808
    Abstract: A method for purifying activated human MMP in E. coli without the use of urea or APMA is provided. In the method, a non-ionic detergent is used in a lysis buffer to solubilize MMP, and the protease activities of trypsin and MMP are utilized to digest the E. coli proteins and activate pro-MMP 1.
    Type: Application
    Filed: February 1, 2019
    Publication date: August 1, 2019
    Inventors: Lokender Kumar, Susanta K. Sarkar