Patents by Inventor Lolita Zamir

Lolita Zamir has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Semi-synthesis of a protected baccatin III compound
    Patent number: 6576777
    Abstract: The present invention relates to a semi-synthetic process to convert a naturally occurring taxane into a suitable starting material for the synthesis of paclitaxel and related compounds. Specifically, the present invention relates to a process for the conversion of 9-dihydro-13-acetylbaccatin III into a 7-protected baccatin III which can then be used as starting material for the synthesis of taxane derivatives such as paclitaxel, docetaxel, cephalomannine and other taxanes structurally related to baccatin III. The method as described uses a preparative scale technique which is amenable to commercial scale-up.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: June 10, 2003
    Assignee: Institut National de la Recherche Scientifique
    Inventors: Lolita Zamir, Gaétan Caron
  • Semi-synthesis of a protected baccatin III compound
    Publication number: 20020128498
    Abstract: The present invention relates to a semi-synthetic process to convert a naturally occurring taxane into a suitable starting material for the synthesis of paclitaxel and related compounds. Specifically, the present invention relates to a process for the conversion of 9-dihydro-13-acetylbaccatin III into a 7-protected baccatin III which can then be used as starting material for the synthesis of taxane derivatives such as paclitaxel, docetaxel, cephalomannine and other taxanes structurally related to baccatin III. The method as described uses a preparative scale technique which is amenable to commercial scale-up.
    Type: Application
    Filed: December 22, 2000
    Publication date: September 12, 2002
    Inventors: Lolita Zamir, Gaetan Caron
  • Family of Canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
    Patent number: 6410756
    Abstract: The present invention relates to a new taxane having the structure as in Formula I, and its analogs as depicted in Formula II and Formula III. The invention includes novel semi-synthetic and isolation methods for the preparation of these novel taxanes. Specifically, the present invention relates to the new taxane Canadensol isolated from plants of the Taxus genus in particular, Taxus canadensis. The present invention further relates to the use of these new taxanes as anticancer agents.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: June 25, 2002
    Assignee: Institut National de la Recherche Scientifique
    Inventors: Lolita Zamir, Gaéton Caron, Yi Feng Zheng
  • Echinops extract with anti-cancer activity
    Patent number: 6395312
    Abstract: The present invention relates to an Extract of Echinops spinosus L (Asteraceae) and organic solvent soluble fractions of the extract that may be used in the treatment of cancer.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: May 28, 2002
    Assignee: McGill University
    Inventors: Moulay A. Alaoui-Jamali, Gerald Batist, Lolita Zamir
  • Family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
    Publication number: 20020045771
    Abstract: The present invention relates to a new taxane having the structure as in formula I and its analogs as depicted in Formula II and Formula III. The invention includes novel semisynthetic and isolation methods for the preparation of these novel taxanes. Specifically, the present invention relates to the new taxane Canadensol isolated from plants of the Taxus genus, in particular, Taxus canadensis. The present invention further relates to the use of these new taxanes as anticancer agents.
    Type: Application
    Filed: October 16, 2001
    Publication date: April 18, 2002
    Applicant: Institut National de la Recherche Scientifique
    Inventors: Lolita Zamir, Gaeton Caron, Yi Feng Zheng
  • Semi-synthesis of a protected baccatin III compound
    Patent number: 6222053
    Abstract: The present invention relates to a semi-synthetic process to convert a naturally occurring taxane into a suitable starting material for the synthesis of paclitaxel and related compounds. Specifically, the present invention relates to a process for the conversion of 9-dihydro-13-acetylbaccatin III into a 7-protected baccatin III which can then be used as starting material for the synthesis of taxane derivatives such as paclitaxel, docetaxel, cephalomannine and other taxanes structurally related to baccatin III. The method as described uses a preparative scale technique which is amenable to commercial scale-up.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: April 24, 2001
    Assignee: Institut National de la Recherche Scientifique
    Inventors: Lolita Zamir, Gaétan Caron
  • Preparative scale isolation and purification of taxanes
    Patent number: 5965752
    Abstract: This invention relates to an improved method for isolating taxanes by using a preparative scale technique amenable to commercial production. This method provides high yields of known taxanes in addition to new taxanes.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: October 12, 1999
    Assignee: Institut National De La Recherche Scientifique
    Inventors: Lolita Zamir, Gaetan Caron