Patents by Inventor Long Meng
Long Meng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12121897Abstract: A microfluidic system, including: a container, an ultrasound transmitter assembly, and a phononic crystal plate. The container is configured to accommodate a solution containing microparticles. The ultrasound transmitter assembly is configured to transmit ultrasonic waves to the phononic crystal plate, where the ultrasonic waves have a frequency which is the same as a resonance frequency of the phononic crystal plate. The phononic crystal plate is placed in the solution, and configured to generate a local acoustic field on a surface of the phononic crystal plate under excitation of the ultrasonic waves, and induce an acoustic microstreaming vortex to generate an acoustic streaming shear stress on the microparticles. The phononic crystal plate defines therein cavities, the respective cavities are arranged periodically in the phononic crystal plate, and all the respective cavities are filled with gas.Type: GrantFiled: December 21, 2018Date of Patent: October 22, 2024Assignee: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGYInventors: Hairong Zheng, Fei Li, Feiyan Cai, Long Meng, Yang Xiao, Fei Yan
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Publication number: 20240150748Abstract: Provided is an acoustic microfluidic system for cell fusion, a preparation method therefor and use thereof, which relates to the technical field of cell fusion. The acoustic microfluidic system of the present invention comprises a signal generator, a power amplifier, a PDMS cavity, a micro-injection pump, a pipeline, an EP tube, a cell recovery container, and a bulk wave transducer/surface acoustic wave transducer. The side wall/bottom of the PDMS cavity is provided with identical microporous structures disposed in a staggered manner The system of the present invention has the advantages of extremely low heat production quantity, simple operation, high repeatability and strong stability, and is suitable for the fusion of homologous cells and non-homologous cells. The system is not only suitable for the fusion of two cells, but also for the fusion of a plurality of cells, and can be widely applied to various types of cells.Type: ApplicationFiled: December 18, 2023Publication date: May 9, 2024Inventors: Long MENG, Xiufang LIU, Hairong ZHENG, Lili NIU, Ning RONG
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Patent number: 11848152Abstract: The application discloses a coating material for fabricating rare earth magnets and a method using the coating material to prepare neodymium-iron-boron (NdFeB) magnets having high coercive force. The coating material includes: alloy powder A and low-melting-point metal powder B. The alloy powder A is heavy rare earth element R powder, or rare earth-metal alloy (RM) powder, or rare earth-metal-hydrogen alloy (RMH) powder. The heavy rare earth elements are Dy and/or Tb, metal is Fe or Co, or an alloy of Fe and Co, and H is hydrogen element. The low-melting-point metal powder B is one or two of Zn, Al, and Ga. The preparation method includes the following steps: the coating material is mixed into a slurry, and the slurry is coated on the surface of NdFeB magnet, and then apply a two-stage diffusion heat treatment to the magnet, followed by an annealing process to obtain a high-coercivity NdFeB magnet.Type: GrantFiled: April 1, 2020Date of Patent: December 19, 2023Assignee: NINGBO JINJI STRONG MAGNETIC MATERIAL CO., LTD.Inventors: Feng Xu, Long Meng, Shimao Shen, Yuanhu Hu
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Publication number: 20230314377Abstract: The present invention discloses a real-time ultrasonic stimulation electric signal recording chip and a preparation method thereof, where the preparation method includes the following steps: S1 manufacturing an interdigital electrode on a piezoelectric substrate to obtain a surface acoustic wave chip, and manufacturing a recording electrode and an electrode lead; S2, manufacturing an insulation protection layer on the chip obtained in the S1, and processing the insulation protection layer to form the recording electrode, so as to obtain a chip combining the interdigital electrode and the recording electrode; S3, preparing a PDMS cavity; and S4, bonding the PDMS cavity prepared in the S3 and the chip obtained in the S2. In the present invention, combining the interdigital electrode generating a surface acoustic wave ultrasound with a multi-channel recording electrode, such that real-time recording of a multi-channel electric signal under ultrasonic stimulation is achieved.Type: ApplicationFiled: June 9, 2023Publication date: October 5, 2023Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCESInventors: Long MENG, Wei ZHOU, Hairong ZHENG, Lili NIU, Zhengrong LIN, Benxian PENG, Farooq UMAR, Yingjian CUI
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Publication number: 20230293914Abstract: The present application provides an ultrasonic wake-up system. The system includes an ultrasonic imaging device, an ultrasound stimulation device, and an ultrasound stimulation effect evaluation device, and acquires an ultrasonic image of a target object through the ultrasonic imaging device, transmits an ultrasound to the target object based on the ultrasonic image through the ultrasound stimulation device, and adjusts the transmitted ultrasound required through the ultrasound stimulation effect evaluation device. Therefore, peripheral nerves are accurately stimulated, an uplink reticular wake-up system is activated, so as to wake up patients with disorders of consciousness.Type: ApplicationFiled: May 30, 2023Publication date: September 21, 2023Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCESInventors: Hairong ZHENG, Wei ZHOU, Long MENG, Lili NIU, Zhengrong LIN, Xiaowei HUANG, Junjie ZOU
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Patent number: 11707635Abstract: Provided is a conscious animal ultrasonic neural regulation device, including a pulse signal generation module, a transducer module and a fixing module. The pulse signal generation module is configured to generate a pulse signal with high energy. The ultrasonic transducer module is configured to convert the pulse signal into an ultrasound. The fixing module includes an upper fixing module and a lower fixing module. The upper fixing module is configured to fix the ultrasonic transducer module, and the lower fixing module is configured to be fixed on an animal neural regulation target point. The upper fixing module and the lower fixing module are connected by a connecting component. The conscious animal neural regulation device of the present disclosure can perform accurate ultrasonic stimulation on a cerebral cortex and subcortex of the animal, thereby exploring and verifying the stimulation effect of the ultrasound on the animal, which is easy in operation and convenient in use.Type: GrantFiled: April 21, 2017Date of Patent: July 25, 2023Assignee: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCESInventors: Hairong Zheng, Hui Zhou, Lili Niu, Ruibiao Guo, Long Meng, Yongchuan Li, Min Su, Jiqing Huang, Ming Qian
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Publication number: 20230151313Abstract: A biological sample sorting method, a surface acoustic wave microfluidic chip, a system, a terminal, and a storage medium are disclosed. The method includes: injecting a mixed solution containing biological samples into a surface acoustic wave microfluidic chip, and applying a first sinusoidal signal thereto forming a standing wave sound field therein to aggregate the biological samples; collecting images of the aggregated biological samples; performing moving target identification and tracking on the images of the biological samples using a deep learning model, performing cluster analysis and classification on a tracked moving target to obtain a target sample, and generating a delay enabling signal of the target sample according to a moving speed of the target sample; and applying a second sinusoidal signal to the surface acoustic wave microfluidic chip according to the delay enable signal to move the target sample thus sorting out the target sample.Type: ApplicationFiled: January 19, 2023Publication date: May 18, 2023Inventors: HAIRONG ZHENG, Long Meng, Weixing Chen, Lili Niu, Xiaoyu Cui
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Patent number: 11511277Abstract: Provided are a microfluidic apparatus, a method and system for introducing a substance into a cell. The microfluidic apparatus includes a cavity channel, a bulk wave generating device and a surface acoustic wave generating device; a microstructure is arranged on an inner wall of the cavity channel, and the microstructure is constructed for forming a bubble by a solution at the microstructure when the solution is injected into the cavity channel; the bulk wave generating device is configured to generate a bulk wave, the bulk wave enables the bubble to resonate for generating a flow field; and the surface acoustic wave generating device is configured to generate a surface acoustic wave and control a position of at least one particle in the solution.Type: GrantFiled: January 3, 2017Date of Patent: November 29, 2022Assignee: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Hairong Zheng, Wei Zhou, Long Meng, Lili Niu, Zhengrong Lin, Kaiyue Wang, Xiaowei Huang
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Patent number: 11433392Abstract: A microfluidic chip (100), an apparatus, a system, and a control and preparation method therefor. The method comprises: a substrate (101), and an electrode layer (102) and a functional layer (103) sequentially formed on the substrate (101), said electrode layer (102) comprising a plurality of electrode groups (1021) arranged in an array, the electrode groups (1021) being used for converting electrical signals into acoustic signals when an electrode group is activated, and transmitting the acoustic signals to the functional layer (103); and the functional layer (103) being used for carrying a sample to be tested, and for absorbing the acoustic wave signals emitted by the activated electrode group (1021) and converting same into thermal energy for heating the sample to be tested that is carried at the position corresponding to the activated electrode group (1021).Type: GrantFiled: June 17, 2020Date of Patent: September 6, 2022Assignee: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGYInventors: Long Meng, Hairong Zheng, Kaiyue Wang, Wei Zhou, Lili Niu, Xiaowei Huang
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Patent number: 11253730Abstract: An ultrasound deep brain stimulation method and system, the ultrasound deep brain stimulation method comprises: medically imaging a head of an animal or a human being, to generate image data; creating a head 3D digital model according to the image data; creating a 3D digital model of an ultrasound transducer array according to structure, density and acoustic parameters information of the ultrasound transducer array; generating a first ultrasound transmitting sequence according to the head 3D digital model, the 3D digital model of the ultrasound transducer array, structure, density and acoustic parameters of the skull and brain tissues, and structure, density and acoustic parameters of the ultrasound transducer array; and controlling the ultrasound transducer array to transmit ultrasound waves in accordance with the first ultrasound transmitting sequence, to implement ultrasound deep brain stimulation to the brain nucleus to be stimulated.Type: GrantFiled: June 22, 2017Date of Patent: February 22, 2022Assignee: GREENVALLEY BRAINTECH (SHENZHEN) MEDICAL TECHNOLOGY CO., LTD.Inventors: Hairong Zheng, Lili Niu, Congzhi Wang, Ming Qian, Yang Xiao, Long Meng
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Publication number: 20220033853Abstract: The gene transfection system includes an acoustothermal module and a signal generating module; the acoustothermal module includes a piezoelectric substrate, an acoustothermal chip arranged on the piezoelectric substrate and N sound-absorbing vessels arranged on the acoustothermal chip and used for cultivating recipient cells, and N is an integer greater than or equal to 1; the signal generating module is used to output basic frequency signals; the acoustothermal chip is used to convert the basic frequency signal to an acoustic wave signal, establish a temperature gradient field with the acoustic wave signal, and control the temperature of the recipient cell in the sound-absorbing vessels with the temperature gradient field, so that the pores are opened on the membranes of the recipient cell, and the nucleic acids or other substances can go into the cells through these pores.Type: ApplicationFiled: July 26, 2018Publication date: February 3, 2022Inventors: Hairong ZHENG, Long MENG, Congzhi WANG, Xiufang LIU, Yuchen WANG, Wei ZHOU, Lili NIU, Xiaowei HUANG
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Publication number: 20210308676Abstract: A microfluidic system, including: a container, an ultrasound transmitter assembly, and a phononic crystal plate. The container is configured to accommodate a solution containing microparticles. The ultrasound transmitter assembly is configured to transmit ultrasonic waves to the phononic crystal plate, where the ultrasonic waves have a frequency which is the same as a resonance frequency of the phononic crystal plate. The phononic crystal plate is placed in the solution, and configured to generate a local acoustic field on a surface of the phononic crystal plate under excitation of the ultrasonic waves, and induce an acoustic microstreaming vortex to generate an acoustic streaming shear stress on the microparticles. The phononic crystal plate defines therein cavities, the respective cavities are arranged periodically in the phononic crystal plate, and all the respective cavities are filled with gas.Type: ApplicationFiled: December 21, 2018Publication date: October 7, 2021Inventors: Hairong ZHENG, Fei LI, Feiyan CAI, Long MENG, Yang XIAO, Fei YAN
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Publication number: 20210296049Abstract: The application discloses a coating material for fabricating rare earth magnets and a method using the coating material to prepare neodymium-iron-boron (NdFeB) magnets having high coercive force. The coating material includes: alloy powder A and low-melting-point metal powder B. The alloy powder A is heavy rare earth element R powder, or rare earth-metal alloy (RM) powder, or rare earth-metal-hydrogen alloy (RMH) powder. The heavy rare earth elements are Dy and/or Tb, metal is Fe or Co, or an alloy of Fe and Co, and H is hydrogen element. The low-melting-point metal powder B is one or two of Zn, Al, and Ga. The preparation method includes the following steps: the coating material is mixed into a slurry, and the slurry is coated on the surface of NdFeB magnet, and then apply a two-stage diffusion heat treatment to the magnet, followed by an annealing process to obtain a high-coercivity NdFeB magnet.Type: ApplicationFiled: April 1, 2020Publication date: September 23, 2021Inventors: Feng XU, Long MENG, Shimao SHEN, Yuanhu HU
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Patent number: 10888462Abstract: Disclosed is an ultrasonic wave generation device for hearing recovery treatment, including an ultrasonic wave generation part. The ultrasonic wave generation part comprises a reference time-delay determination module, an emission sequence parameter determination module and an ultrasonic transducer module. The ultrasonic transducer module is used for emitting actual ultrasonic waves, and the efficiency and precision are improved by focusing by means of a plurality of array elements.Type: GrantFiled: February 8, 2017Date of Patent: January 12, 2021Assignee: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Hairong Zheng, Zhengrong Lin, Lili Niu, Long Meng, Wei Zhou, Xiaowei Huang, Kaiyue Wang
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Publication number: 20200338548Abstract: Provided are a microfluidic apparatus, a method and system for introducing a substance into a cell. The microfluidic apparatus includes a cavity channel, a bulk wave generating device and a surface acoustic wave generating device; a microstructure is arranged on an inner wall of the cavity channel, and the microstructure is constructed for forming a bubble by a solution at the microstructure when the solution is injected into the cavity channel; the bulk wave generating device is configured to generate a bulk wave, the bulk wave enables the bubble to resonate for generating a flow field; and the surface acoustic wave generating device is configured to generate a surface acoustic wave and control a position of at least one particle in the solution.Type: ApplicationFiled: January 3, 2017Publication date: October 29, 2020Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Hairong Zheng, Wei Zhou, Long Meng, Lili Niu, Zhengrong Lin, Kaiyue Wang, Xiaowei Huang
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Publication number: 20200316585Abstract: A microfluidic chip (100), an apparatus, a system, and a control and preparation method therefor. The method comprises: a substrate (101), and an electrode layer (102) and a functional layer (103) sequentially formed on the substrate (101), said electrode layer (102) comprising a plurality of electrode groups (1021) arranged in an array, the electrode groups (1021) being used for converting electrical signals into acoustic signals when an electrode group is activated, and transmitting the acoustic signals to the functional layer (103); and the functional layer (103) being used for carrying a sample to be tested, and for absorbing the acoustic wave signals emitted by the activated electrode group (1021) and converting same into thermal energy for heating the sample to be tested that is carried at the position corresponding to the activated electrode group (1021).Type: ApplicationFiled: June 17, 2020Publication date: October 8, 2020Inventors: LONG MENG, Hairong Zheng, Kaiyue Wang, Wei Zhou, Lili Niu, Xiaowei Huang
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Patent number: 10780437Abstract: Disclosed is a microfluidic system based on an artificially structured acoustic field, comprising a microcavity used to accommodate a solution containing particles and a ultrasonic emission device used to emit ultrasound, and further comprising a phononic crystal plate placed in the microcavity. The phononic crystal plate has an artificial cycle structure, and is used to modulate the acoustic field so as to control the particles. Also disclosed is a method of controlling microfluid particles based on an artificially structured acoustic field. In the particular embodiments, since a microcavity, an ultrasonic emission device and a phononic crystal plate are comprised, the ultrasonic emission device is used to emit ultrasound, and the phononic crystal plate has an artificial cycle structure, and is used to modulate the acoustic field so as to control the particles.Type: GrantFiled: October 10, 2015Date of Patent: September 22, 2020Assignee: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Hairong Zheng, Fei Li, Feiyan Cai, Long Meng, Chen Wang, Chengxiang Zhang, Weibao Qiu, Yongchuan Li, Fei Yan, Lili Niu, Liufeng Geng, Chaowei Xu
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Patent number: 10655198Abstract: A method and apparatus for step-by-step retrieving valuable metals from waste printed circuit board particles. Many kinds of metals, most existing in form of elementary substance or alloy, are contained in the waste printed circuit boards. Molten metals are separated selectively by supergravity separation at different temperatures to achieve the step-by-step recovery. Tin-based alloys, lead-based alloy, zinc aluminum alloy, crude copper and precious-metal-enriched residues with different metal contents are separated out and collected on the condition of different temperatures (T=200˜300° C., 330˜430° C., 700˜900° C., 1100˜1300° C.) and controlling the gravity coefficient (G=50˜1000) and separation time (t=2˜20 min) etc. Different metals or alloys can be separated quickly and efficiently and the residue concentration of precious metals can be obtained. The process is simple and low cost to provide an efficient way to recovery the enrichment of valuable metals from electronic wastes.Type: GrantFiled: August 30, 2017Date of Patent: May 19, 2020Inventors: Zhancheng Guo, Long Meng, Lei Guo, Jintao Gao, Yiwei Zhong, Zhe Wang, Kuiyuan Chen
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Patent number: D908597Type: GrantFiled: August 26, 2019Date of Patent: January 26, 2021Assignee: XUZHOU ARMOUR RUBBER CO., LTD.Inventors: Long Meng, Keke Zhao, Wenqi Zhang, Xinghai Zhao
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Patent number: D908598Type: GrantFiled: August 26, 2019Date of Patent: January 26, 2021Assignee: XUZHOU ARMOUR RUBBER CO., LTD.Inventors: Long Meng, Keke Zhao, Wenqi Zhang, Xinghai Zhao